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Literature summary for 1.14.19.77 extracted from
- Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine (1973), J. Biol. Chem., 248, 1609-1615.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heat-lable factor of high molecular weight | contained in the 100000 * g supernatant | Mesocricetus auratus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Mesocricetus auratus |  |
| cholate | weak inhibition | Mesocricetus auratus | |
| CN- | - |
Mesocricetus auratus | |
| EDTA | - |
Mesocricetus auratus | |
| menadione | - |
Mesocricetus auratus | |
| NaN3 | - |
Mesocricetus auratus | |
| NEM | - |
Mesocricetus auratus | |
| oleate | weak inhibition | Mesocricetus auratus | |
| p-chloromercuribenzoate | - |
Mesocricetus auratus | |
| taurocholate | - |
Mesocricetus auratus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mesocricetus auratus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mesocricetus auratus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2 | Mesocricetus auratus | - |
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
adult animals of either sex | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O | mixed function oxidase | Mesocricetus auratus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| small intestine mucosa | - |
Mesocricetus auratus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0000028 | - |
microsomes plus soluble fraction, enzyme requires a heat-labile factor of high molecular weight contained in the soluble fraction | Mesocricetus auratus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrates: O-3-alkyl-2-acyl-sn-glycero-1-phosphoethanolamine, octadecylglycerol, octadecanal, octadecanol, stearic acid | Mesocricetus auratus | ? | - |
? | |
| additional information | electron donors: NADPH or NADH | Mesocricetus auratus | ? | - |
? | |
| O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2 | - |
Mesocricetus auratus | O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
enzyme assay | Mesocricetus auratus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | phosphate buffer | Mesocricetus auratus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mesocricetus auratus | |
| NADPH | or NADH | Mesocricetus auratus | |
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Release 2023.1 (January 2023)
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