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Literature summary for 1.14.19.68 extracted from

  • Rueffer, M.
    New reactions in the protoberberine biosynthetic pathway (1993), Chem. Listy, 87, 215-217.
No PubMed abstract available
Search for more literature for 1.14.19.68

Inhibitors

Inhibitors Comment Organism Structure
CO inhibition can be partly reverted by blue light Berberidaceae
CO inhibition can be partly reverted by blue light Ranunculaceae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 Berberidaceae reaction in protoberberine biosynthetic pathway (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 Ranunculaceae reaction in protoberberine biosynthetic pathway (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Berberidaceae
-
-
-
Ranunculaceae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2
-
 Berberidaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2
-
 Ranunculaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 reaction in protoberberine biosynthetic pathway Berberidaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 reaction in protoberberine biosynthetic pathway Ranunculaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 23% of the activity compared to NADPH Berberidaceae ?
-
 ?
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 23% of the activity compared to NADPH Ranunculaceae ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 cytochrome P-450 enzyme Berberidaceae
cytochrome P450 cytochrome P-450 enzyme Ranunculaceae