Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | aging, diabetes, viral infection, high alcohol intake, high level cholesterol, high blood pressure, radiation, stress-related hormones, deficiencies of zinc, magnesium, biotin, the vitamins C, B6, and B3, and excessive level of trans fatty acid reduce the enzyme activity in vivo | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | Homo sapiens | - |
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? | |
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | Homo sapiens | - |
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95864 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Homo sapiens | stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? | |
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Homo sapiens | gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D6 desaturase | - |
Homo sapiens |
D6D | - |
Homo sapiens |
DELTA-6-desaturase | - |
Homo sapiens |
FADS2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme follows the omega3 and omega6 pathways. Regulation of surface-membrane enzymes such as delta-6-desaturase and secretory phospholipase A2 by hemp seed and evening primrose oils as well as hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients having beneficial effects in improving clinical symptoms and signs in the patients, possible mechanisms, overview | Homo sapiens |
physiological function | regulation of surface-membrane enzymes such as delta-6-desaturase and secretory phospholipase A2 by hemp seed and evening primrose oils as well as hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients having beneficial effects in improving clinical symptoms and signs in the patients, possible mechanisms, overview. FADS2 enzyme catalyzes the rate-limiting step in the biosynthetic pathways for polyunsaturated fatty acids that are incorporated into cell membranes, thereby affecting permeability, and functional propertiesof cells. There isa correlation between multile sclerosis and a rapid fall of FADS6 enzyme activity | Homo sapiens |