Literature summary for 1.14.19.1 extracted from

Major, C.A.; Ryan, K.; Bennett, A.J.; Lock, A.L.; Bauman, D.E.; Salter, A.M.
Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster (2008), J. Lipid Res., 49, 1456-1465.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme expression is increased by feeding of cholesterol and sterculic oil in parallel, enzyme expression levels and metabolic effects, overview	Mesocricetus auratus

Inhibitors

Inhibitors	Comment	Organism	Structure
sterculic oil	in vivo enzyme inhibition by feeding sterculic oil	Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mesocricetus auratus	inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	male Golden Syrian Hamsters	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mesocricetus auratus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview	Mesocricetus auratus	?	-	?

Synonyms

Synonyms	Comment	Organism
SCD	-	Mesocricetus auratus
stearoyl CoA desaturase	-	Mesocricetus auratus

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Release 2023.1 (January 2023)