Literature summary for 1.14.14.9 extracted from

Kim, H.; Kim, S.; Kim, D.; Yoon, S.H.
A single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate (2020), BMC Microbiol., 20, 109 .

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Protein Variants

Protein Variants	Comment	Organism
R379G	contrary to wild-type, mutant is not able to grow on 3-hydroxyphenylacetic acid. Residue 379 is located in the vicinity of the 4-hydroxyphenylacetic acid binding site, and plays an important role in mediating the entrance and stable binding of substrates to the active site	Escherichia coli
R379S	contrary to wild-type, mutant is not able to grow on 3-hydroxyphenylacetic acid	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	A0A140NG21	-	-
Escherichia coli BL21-DE3	A0A140NG21	-	-

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Release 2023.1 (January 2023)