Literature summary for 1.14.14.55 extracted from

Mirghani, R.A.; Yasar, U.; Zheng, T.; Cook, J.M.; Gustafsson, L.L.; Tybring, G.; Ericsson, O.
Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway (2002), Drug Metab. Dispos., 30, 1368-1371 .

Search for more literature for 1.14.14.55

Inhibitors

Inhibitors	Comment	Organism	Structure
ketoconazole	complete inhibition at 0.1 mM	Homo sapiens
additional information	not inhibited by fluvoxamine	Homo sapiens
troleandomycin	complete inhibition at 0.08 mM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
quinine + [reduced NADPH-hemoprotein reductase] + O2	Homo sapiens	-	3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
quinine + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP3A4	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)