Activating Compound | Comment | Organism | Structure |
---|---|---|---|
grape seed extract | some brands cause minor activation of CYP3A4 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | green tea extract use may cause significant interactions with drugs metabolized by CYP3A4. Effect on CYP3A4 varies among different brands of green tea extract, possibly due to variations in their content of the herbal product's active ingredients | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
grape seed extract | inhibition ranges from 6.4% to 26.8% dependent on the product | Homo sapiens | |
green tea extract | most pronounced inhibition of CYP3A4, which ranges from 5.6% to 89.9% dependent on the product | Homo sapiens | |
additional information | ginseng products have little to no effect on the activity of CYP3A4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08684 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP3A4 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |