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Literature summary for 1.14.14.114 extracted from

  • Muangphrom, P.; Seki, H.; Suzuki, M.; Komori, A.; Nishiwaki, M.; Mikawa, R.; Fukushima, E.O.; Muranaka, T.
    Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species the discovery of novel koidzumiol and (+)-alpha-bisabolol synthases (2016), Plant Cell Physiol., 57, 1678-1688 .
    View publication on PubMed
Search for more literature for 1.14.14.114

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Artemisia annua
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Artemisia afra
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Artemisia absinthium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] Artemisia annua
-
 artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] Artemisia afra
-
 artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] Artemisia absinthium
-
 artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase] Artemisia kurramensis
-
 artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Artemisia absinthium K7ZPJ9
-
-
Artemisia afra K7ZR99
-
-
Artemisia annua Q1PS23
-
-
Artemisia kurramensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Artemisia annua
-
leaf
-
 Artemisia afra
-
leaf
-
 Artemisia absinthium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
-
 Artemisia annua artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
-
 Artemisia afra artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
-
 Artemisia absinthium artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
-
 Artemisia kurramensis artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP71AV1
-
 Artemisia annua
CYP71AV1
-
 Artemisia afra
CYP71AV1
-
 Artemisia absinthium
CYP71AV1
-
 Artemisia kurramensis

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Artemisia annua
cytochrome P450
-
 Artemisia afra
cytochrome P450
-
 Artemisia absinthium
cytochrome P450
-
 Artemisia kurramensis
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Artemisia annua
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Artemisia afra
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Artemisia absinthium
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Artemisia kurramensis

General Information

General Information Comment Organism
metabolism the enzyme is involved in the artemisinin biosynthesis Artemisia annua
metabolism the enzyme is involved in the artemisinin biosynthesis Artemisia afra
metabolism the enzyme is involved in the artemisinin biosynthesis Artemisia absinthium
metabolism the enzyme is involved in the artemisinin biosynthesis Artemisia kurramensis
physiological function amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde Artemisia annua
physiological function amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde Artemisia afra
physiological function amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde Artemisia absinthium
physiological function amorpha-4,11-diene 12-monooxygenase (CYP71AV1) catalyzes the multistep oxidation of amorpha-4,11-diene to artemisinic alcohol and artemisinic aldehyde Artemisia kurramensis