Application | Comment | Organism |
---|---|---|
medicine | in transgenic mice with altered cytochrome P450 lipid biosynthetic pathways in a mouse model of laser-induced choroidal neovascularization, overexpression of the human monooxygenase CYP2C8 or genetic ablation or inhibition of the soluble epoxide hydrolase enzyme leads to increased levels of epoxydocosapentaenoic acids and epoxyeicosatetraenoic acids with attenuated choroidal neovascularization development. The molecules work in part through their ability to regulate the expression of key leukocyte adhesion molecules, on both leukocytes and endothelial cells, thereby mediating leukocyte recruitment | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
CYP2C8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in transgenic mice with altered cytochrome P450 lipid biosynthetic pathways in a mouse model of laser-induced choroidal neovascularization, overexpression of the human monooxygenase CYP2C8 or genetic ablation or inhibition of the soluble epoxide hydrolase enzyme leads to increased levels of epoxydocosapentaenoic acids and epoxyeicosatetraenoic acids with attenuated choroidal neovascularization development | Homo sapiens |