Cloned (Comment) | Organism |
---|---|
coexpression of CYP1A2 with the Y459H and V492E mutant POR alleles in tBTC1A2_POR cell-models | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CYP1A2, and likely other drug-metabolizing CYPs, are impaired by Antley-Bixler syndrome-related cytochrome P450 reductase mutations as observed in the steroidogenic CYPs | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
7-methoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP1A2 | - |
Homo sapiens |
cytochrome P450 oxidoreductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | FAD totally recovers activities in the BTC1A2_PORV492E membranes, for both 7-ethoxyresorufin and 7-methoxyresorufin, but only partially recovers these activities in the BTC1A2_PORY459H membranes | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Y459H and V492E mutant POR alleles severely hinder the CYP1A2-mediated bioactivation of the three pro-carcinogens 2-aminoanthracene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 2-amino-3-methylimidazo(4,5-f)quinoline | Homo sapiens |