BRENDA - Enzyme Database show
show all sequences of 1.14.13.9

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys

Gregoire, L.; Rassoulpour, A.; Guidetti, P.; Samadi, P.; Bedard, P.J.; Izzo, E.; Schwarcz, R.; Di Paolo, T.; Behav. Brain Res. 186, 161-167 (2008)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Ro 61-8048
-
Macaca fascicularis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-kynurenine + NADPH + H+ + O2
Macaca fascicularis
prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys, enzyme regulation and involvement in Parkinson's disease, overview
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Macaca fascicularis
-
ovariectomized female cynomolgus monkeys
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
MPTP-treated monkeys
Macaca fascicularis
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-kynurenine + NADPH + H+ + O2
-
684812
Macaca fascicularis
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
-
?
L-kynurenine + NADPH + H+ + O2
prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys, enzyme regulation and involvement in Parkinson's disease, overview
684812
Macaca fascicularis
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Macaca fascicularis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Macaca fascicularis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Ro 61-8048
-
Macaca fascicularis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-kynurenine + NADPH + H+ + O2
Macaca fascicularis
prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys, enzyme regulation and involvement in Parkinson's disease, overview
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
MPTP-treated monkeys
Macaca fascicularis
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-kynurenine + NADPH + H+ + O2
-
684812
Macaca fascicularis
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
-
?
L-kynurenine + NADPH + H+ + O2
prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys, enzyme regulation and involvement in Parkinson's disease, overview
684812
Macaca fascicularis
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
-
?
Other publictions for EC 1.14.13.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741802
Tashiro
Kynurenine 3-monooxygenase is ...
Mus musculus
Behav. Brain Res.
317
279-285
2017
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3
3
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742039
Erhardt
Adaptive and behavioral chang ...
Mus musculus
Biol. Psychiatry
82
756-765
2017
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2
2
-
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742081
Phillips
Substrate and inhibitor speci ...
Cytophaga hutchinsonii
Bioorg. Med. Chem. Lett.
27
1705-1708
2017
-
2
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8
3
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1
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2
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3
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7
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2
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8
7
3
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1
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3
-
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-
3
-
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1
1
-
3
3
742082
Liddle
The discovery of potent and s ...
Homo sapiens
Bioorg. Med. Chem. Lett.
27
2023-2028
2017
-
-
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-
31
-
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1
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1
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1
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1
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31
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1
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2
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1
1
-
-
-
742478
Gao
Biochemistry and structural s ...
Homo sapiens, Pseudomonas fluorescens
FASEB J.
FEHLT
0000
2017
-
1
1
1
25
-
2
-
-
-
2
-
-
4
-
1
1
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2
-
2
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-
2
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-
1
-
-
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1
1
-
1
25
-
-
2
1
-
-
-
2
-
-
-
1
1
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
1
1
-
-
-
743067
Walker
Development of a series of ky ...
Pseudomonas fluorescens
J. Med. Chem.
60
3383-3404
2017
-
-
-
-
-
-
34
-
-
-
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-
2
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33
-
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33
34
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-
-
-
-
-
-
-
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-
1
1
-
-
-
743342
Hutchinson
Structural and mechanistic ba ...
Homo sapiens, Pseudomonas fluorescens
Nat. Commun.
8
15827
2017
-
2
-
-
-
-
12
-
-
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-
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3
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2
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8
-
2
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2
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8
12
-
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-
-
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-
3
3
-
-
-
743358
Gonzalez Esquivel
Kynurenine pathway metabolite ...
Homo sapiens, Rattus norvegicus
Neuropharmacology
112
331-345
2017
-
-
-
-
-
-
-
-
-
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2
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4
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2
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2
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2
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4
-
-
2
-
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-
-
-
-
-
-
-
1
2
2
1
-
-
742349
Smith
Kynurenine-3-monooxygenase a ...
Homo sapiens, Pseudomonas fluorescens, Rattus norvegicus, Sus scrofa
Drug Discov. Today
21
315-324
2016
-
1
-
-
-
-
2
-
2
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5
-
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5
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4
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1
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4
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2
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2
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5
-
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-
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-
-
-
-
-
-
-
3
3
-
-
-
743747
Wilson
Bacterial expression of human ...
Homo sapiens
Protein Expr. Purif.
95
96-103
2014
-
-
1
-
-
-
-
4
1
-
-
-
-
2
-
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1
-
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1
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1
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1
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1
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1
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-
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2
2
-
-
-
724908
Stephens
Kynurenine 3-monooxygenase med ...
Mus musculus
Eur. J. Immunol.
43
1727-1734
2013
-
1
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1
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1
1
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725567
Winkler
Development of LC/MS/MS, high- ...
Homo sapiens
J. Biomol. Screen.
18
879-889
2013
-
1
-
-
-
-
3
1
-
-
-
-
-
3
-
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1
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1
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3
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1
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3
3
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1
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1
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1
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-
-
726040
Amaral
Structural basis of kynurenine ...
Saccharomyces cerevisiae
Nature
496
382-385
2013
-
-
1
1
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1
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4
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712322
Hirai
Dual role of the carboxyl-term ...
Sus scrofa
J. Biochem.
148
639-650
2010
-
-
1
-
1
-
-
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2
-
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2
-
4
-
-
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2
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2
1
1
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1
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3
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1
3
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1
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2
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2
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2
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2
1
1
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1
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1
1
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-
705250
Amori
On the relationship between th ...
Rattus norvegicus
J. Neurochem.
109
316-325
2009
-
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2
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2
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684812
Gregoire
Prolonged kynurenine 3-hydroxy ...
Macaca fascicularis
Behav. Brain Res.
186
161-167
2008
-
-
-
-
-
-
1
-
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1
-
4
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1
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2
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1
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689224
Connor
Induction of indolamine 2,3-di ...
Rattus norvegicus
Neurosci. Lett.
441
29-34
2008
1
-
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702221
Crozier-Reabe
Kynurenine 3-monooxygenase fro ...
Pseudomonas fluorescens
Biochemistry
47
12420-12433
2008
-
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1
-
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3
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1
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2
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675556
Ceresoli-Borroni
Perinatal kynurenine 3-hydroxy ...
Mus musculus, Rattus norvegicus
J. Neurosci. Res.
85
845-854
2007
-
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2
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2
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6
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676975
Crozier
Heterologous expression and pu ...
Pseudomonas fluorescens, Pseudomonas fluorescens 17400
Protein Expr. Purif.
51
324-333
2007
-
1
1
-
-
1
1
7
-
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1
2
-
3
-
-
1
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1
1
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4
1
1
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2
1
1
4
2
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1
1
2
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1
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1
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7
-
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1
2
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1
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1
1
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4
1
1
-
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2
1
1
4
-
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687098
Quan
-
Rescue of white egg 1 mutant b ...
Bombyx mori, Bombyx mori C108
Insect Sci.
14
85-92
2007
-
1
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1
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1
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3
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4
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1
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2
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1
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1
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7
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1
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-
1
1
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-
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742657
Quan
-
Rescue of white egg 1 mutant ...
Bombyx mori
Insect Sci.
14
85-92
2007
-
-
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1
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2
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2
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-
1
1
-
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675745
Ragazzi
Cloricromene effect on the enz ...
Oryctolagus cuniculus
Life Sci.
78
785-794
2006
-
-
-
-
-
-
1
-
1
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1
-
4
-
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2
2
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2
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1
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1
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1
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1
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2
2
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2
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659985
Giorgini
A genomic screen in yeast impl ...
Homo sapiens, Saccharomyces cerevisiae
Nat. Genet.
37
526-531
2005
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1
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660112
Ligam
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673130
Comai
The effect of age on the enzym ...
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Clin. Chim. Acta
360
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2005
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657495
Allegri
Kynurenine pathway enzymes in ...
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7
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8
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Analysis of the wild-type and ...
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1
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1
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1
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4
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6
1
1
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3
1
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Lorenzen
Cloning and characterization o ...
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1
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658918
Hirai
cDNA cloning, functional expre ...
Anopheles stephensi
Insect Mol. Biol.
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2
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2
2
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4
2
1
2
2
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1
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348532
Chiarugi
Kynurenine 3-momo-oxygenase ac ...
Rattus norvegicus
Neuroscience
102
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2001
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1
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2
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348531
Breton
Functional characterization an ...
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Eur. J. Biochem.
267
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3
2
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1
3
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2
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2
1
1
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1
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Drysdale
Synthesis and SAR of 4-aryl-2- ...
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Urenjak
Kynurenine 3-hydroxylase inhib ...
Rattus norvegicus
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348528
Uemura
Purification of L-kynurenine 3 ...
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467
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1999
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348529
Cozzi
Kynurenine hydroxylase inhibit ...
Meriones unguiculatus, Rattus norvegicus
J. Cereb. Blood Flow Metab.
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1999
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4
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348530
Heidempergher
Pyrrolo[3,2-c]quinoline deriva ...
Rattus norvegicus
Farmaco
54
152-160
1999
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348525
Giordani A.; Pevarello P.; Cini
4-phenyl-4-oxo-butanoic acid d ...
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Bioorg. Med. Chem. Lett.
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348527
Rover
Synthesis and biochemical eval ...
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348535
Alberati-Giani
Cloning and functional express ...
Homo sapiens
FEBS Lett.
410
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348526
Speciale
Kynurenic acid-enhancing and a ...
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398
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1996
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348536
Pellicciari
Modulation of the kynurenine p ...
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37
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348521
Saito
Kynurenine 3-hydroxylase in br ...
Homo sapiens, Macaca mulatta, Meriones unguiculatus, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
307
104-109
1993
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5
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1
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11
5
1
4
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1
2
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1
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348524
Shin
Inhibition of L-kynurenine 3-h ...
Saccharomyces pastorianus
J. Nutr. Sci. Vitaminol.
28
191-201
1982
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348519
McLean-Bowen
Corresponding changes in kynur ...
Saccharomyces cerevisiae
J. Bacteriol.
145
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1981
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1
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2
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1
-
1
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348523
Stratakis
-
Subcellular localization and p ...
Ephestia kuehniella
J. Comp. Physiol.
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451-456
1981
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1
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1
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1
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3
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2
1
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1
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1
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1
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348518
Nishimoto
Purification of L-kynurenine 3 ...
Rattus norvegicus
J. Chromatogr.
169
357-364
1979
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1
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1
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1
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1
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1
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2
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1
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1
1
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1
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1
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348516
Nisimoto
Molecular properties of L-kynu ...
Rattus norvegicus
J. Biochem.
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3
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3
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1
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1
1
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2
1
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348517
Nisimoto
Isolation of L-kynurenine 3-hy ...
Rattus norvegicus
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1
1
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1
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348522
Pinamonti
-
Kynurenine-3-hydroxylase of Sc ...
Schistocerca gregaria
Insect Biochem.
4
9-16
1974
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2
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1
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348520
Schott
The regulatory function of L-k ...
Saccharomyces cerevisiae
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352
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1971
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1
1
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2
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4
1
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1
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2
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348514
Okamoto
Flavin adenine dinucleotide re ...
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Biochem. Biophys. Res. Commun.
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2
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348515
Saito
Studies on oxygenases: Enzymat ...
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5
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6
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1
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