Literature summary for 1.14.13.168 extracted from

Zhu, Y.; Li, H.J.; Su, Q.; Wen, J.; Wang, Y.; Song, W.; Xie, Y.; He, W.; Yang, Z.; Jiang, K.; Guo, H.
A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis (2019), J. Biol. Chem., 294, 19923-19933 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
ponalrestat	ponalrestat suppresses the native auxin signal and protects a GST-YUC2 fusion protein from Pronase degradation. Ponalrestat has an inhibitory effect on YUC2 protein, fits into the active site pocket of YUC2 and may act as a substrate antagonist. Treatment suppresses root hair formation and interrupts root gravitropic growth; ponalrestat suppresses the native auxin signal. Treatment suppresses root hair formation and interrupts root gravitropic growth	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	O23024	isoform YUC3	-
Arabidopsis thaliana	Q9SVQ1	isoform YUC2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
root	highly expressed in root	Arabidopsis thaliana	-

Synonyms

Synonyms	Comment	Organism
YUC2	-	Arabidopsis thaliana
YUC3	-	Arabidopsis thaliana
YUCCA	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
physiological function	a quintuple mutant, with mutations in isoforms YUC3, YUC5, YUC7, YUC8, and YUC9, lost sensitivity to both the negative effects of ethylene precursor ACC and the positive effects of ponalrestat in root elongation	Arabidopsis thaliana

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Release 2023.1 (January 2023)