BRENDA - Enzyme Database show
show all sequences of 1.14.11.B1

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

Pedanou, V.E.; Gobeil, S.; Tabaries, S.; Simone, T.M.; Zhu, L.J.; Siegel, P.M.; Green, M.R.; eLife 5, e16844 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene KDM3A, quantitative RT-PCR enzyme expression analysis, recombinant expression of wild-type KDM3A or catalytically inactive KDM3A mutant [KDM3A(H1120G/D1122N)] in MCF-10A cells
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
H1120G/D1122N
a catalytically-inactive KDM3A mutant
Homo sapiens
additional information
RNAi-mediated knockdown of KDM3A, Kdm3a knockdown 4T07 cells
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular matrix
-
Homo sapiens
31012
-
nucleus
-
Homo sapiens
5634
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 L-lysine9 + succinate + formaldehyde + CO2
-
-
?
additional information
Homo sapiens
KDM3A is a histone demethylase that specifically demethylates mono-methylated (me1) and di-methylated (me2) histone H3 lysine 9 (H3K9)
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9Y4C1
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
breast epithelial cell
-
Homo sapiens
-
BT-549 cell
-
Homo sapiens
-
epithelial cell
-
Homo sapiens
-
MCF-10A cell
-
Homo sapiens
-
SUM-149 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
744782
Homo sapiens
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
744782
Homo sapiens
histone H3 L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
additional information
KDM3A is a histone demethylase that specifically demethylates mono-methylated (me1) and di-methylated (me2) histone H3 lysine 9 (H3K9)
744782
Homo sapiens
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
gene KDM3A, quantitative RT-PCR enzyme expression analysis, recombinant expression of wild-type KDM3A or catalytically inactive KDM3A mutant [KDM3A(H1120G/D1122N)] in MCF-10A cells
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H1120G/D1122N
a catalytically-inactive KDM3A mutant
Homo sapiens
additional information
RNAi-mediated knockdown of KDM3A, Kdm3a knockdown 4T07 cells
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular matrix
-
Homo sapiens
31012
-
nucleus
-
Homo sapiens
5634
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 L-lysine9 + succinate + formaldehyde + CO2
-
-
?
additional information
Homo sapiens
KDM3A is a histone demethylase that specifically demethylates mono-methylated (me1) and di-methylated (me2) histone H3 lysine 9 (H3K9)
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
breast epithelial cell
-
Homo sapiens
-
BT-549 cell
-
Homo sapiens
-
epithelial cell
-
Homo sapiens
-
MCF-10A cell
-
Homo sapiens
-
SUM-149 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
744782
Homo sapiens
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
744782
Homo sapiens
histone H3 L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
additional information
KDM3A is a histone demethylase that specifically demethylates mono-methylated (me1) and di-methylated (me2) histone H3 lysine 9 (H3K9)
744782
Homo sapiens
?
-
-
-
-
Expression
Organism
Commentary
Expression
Homo sapiens
in attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression. Expression of either EGFR or MEK2DD decreases the levels of KDM3A in detached MCF10A cells
down
Homo sapiens
in attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression. KDM3A protein levels are increased in attached MCF-10A cells treated with the EGFR inhibitor gefitinib. Detachment and loss of integrin and growth factor receptor signaling induces KDM3A expression
up
General Information
General Information
Commentary
Organism
malfunction
RNAi-mediated knockdown of KDM3A substantially reduces apoptosis following detachment and, conversely, ectopic expression of KDM3A induces cell death in attached cells. Knockdown of Kdm3a enhances metastatic potential in a mouse model of breast cancer metastasis. Defective KDM3A expression in human breast cancer cell lines and tumors. Kdm3a knockdown significantly increases the number of cells that survived in the mouse lung relative to the control NS shRNA
Homo sapiens
additional information
in attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression
Homo sapiens
physiological function
epithelial cells that lose attachment to the extracellular matrix (ECM), or attach to an inappropriate ECM, undergo a specialized form of apoptosis called anoikis. Anoikis has an important role in preventing oncogenesis, particularly metastasis, by eliminating cells that lack proper ECM cues. Histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L. KDM3A demethylates H3K9me1/2 to stimulate expression of one or more pro-apoptotic genes. KDM3A promotes anoikis through transcriptional activation of BNIP3 and BNIP3L, which encode pro-apoptotic proteins. Identification of KDM3A as an anoikis effector in breast cancer epithelial cells, overview
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
RNAi-mediated knockdown of KDM3A substantially reduces apoptosis following detachment and, conversely, ectopic expression of KDM3A induces cell death in attached cells. Knockdown of Kdm3a enhances metastatic potential in a mouse model of breast cancer metastasis. Defective KDM3A expression in human breast cancer cell lines and tumors. Kdm3a knockdown significantly increases the number of cells that survived in the mouse lung relative to the control NS shRNA
Homo sapiens
additional information
in attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression
Homo sapiens
physiological function
epithelial cells that lose attachment to the extracellular matrix (ECM), or attach to an inappropriate ECM, undergo a specialized form of apoptosis called anoikis. Anoikis has an important role in preventing oncogenesis, particularly metastasis, by eliminating cells that lack proper ECM cues. Histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L. KDM3A demethylates H3K9me1/2 to stimulate expression of one or more pro-apoptotic genes. KDM3A promotes anoikis through transcriptional activation of BNIP3 and BNIP3L, which encode pro-apoptotic proteins. Identification of KDM3A as an anoikis effector in breast cancer epithelial cells, overview
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
in attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression. Expression of either EGFR or MEK2DD decreases the levels of KDM3A in detached MCF10A cells
down
Homo sapiens
in attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression. KDM3A protein levels are increased in attached MCF-10A cells treated with the EGFR inhibitor gefitinib. Detachment and loss of integrin and growth factor receptor signaling induces KDM3A expression
up
Other publictions for EC 1.14.11.B1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743916
Hancock
The activity of JmjC histone ...
Homo sapiens
ACS Chem. Biol.
12
1011-1019
2017
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1
1
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1
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4
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3
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2
2
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743984
Cai
Histone demethylase JMJD1C re ...
Homo sapiens
Am. J. Cancer Res.
7
115-124
2017
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1
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1
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1
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1
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11
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11
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1
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2
2
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744413
Maina
Histone demethylase PHF8 regu ...
Homo sapiens
Biochim. Biophys. Acta
1860
1002-1012
2017
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1
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2
2
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744494
Amano
Development and crystallograp ...
Homo sapiens
Bioorg. Med. Chem.
25
2617-2624
2017
-
-
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1
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15
-
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1
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1
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15
13
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1
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1
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1
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-
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745030
Audonnet
JMJ24 antagonizes histone H3K ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Gene Expr. Patterns
25-26
1-7
2017
-
-
1
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1
-
-
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4
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5
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4
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-
-
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2
4
-
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745752
Liu
LincRNAFEZF1-AS1 represses p2 ...
Homo sapiens
Mol. Cancer
16
39
2017
-
-
-
-
-
-
-
-
1
1
-
3
-
1
-
-
-
-
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3
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3
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1
1
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3
-
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3
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745771
Vyas
Lysine-specific demethylase-1 ...
Mus musculus
Mol. Cell. Neurosci.
82
1-11
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745949
An
HistoneH3 demethylase JMJD2A ...
Homo sapiens
Oncotarget
8
49093-49109
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
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1
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1
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1
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1
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4
-
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1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745951
Qin
The histone demethylase Kdm3a ...
Mus musculus
Oncotarget
8
84761-84775
2017
1
-
-
-
1
-
-
-
1
1
-
3
-
2
-
-
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5
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4
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1
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1
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1
1
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3
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5
-
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4
-
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-
-
-
-
-
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-
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3
3
-
-
-
746085
Dutta
JMJ27, an Arabidopsis H3K9 hi ...
Arabidopsis thaliana
Plant J.
91
1015-1028
2017
-
-
1
-
1
-
-
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1
1
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2
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3
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4
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4
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5
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1
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1
-
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-
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1
3
3
1
-
-
746217
Jang
Histone H3K9 demethylase JMJD ...
Homo sapiens
PLoS ONE
12
e0168185
2017
-
-
1
-
1
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-
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1
1
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2
-
1
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3
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2
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1
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1
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3
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2
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4
4
-
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744236
Choi
KDM7A histone demethylase med ...
Homo sapiens
Biochem. Biophys. Res. Commun.
478
1355-1362
2016
-
-
1
-
1
-
-
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2
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1
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2
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2
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1
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1
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1
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1
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2
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1
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-
-
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2
2
-
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744347
Burg
Lysine-specific demethylase 1 ...
Homo sapiens
Biochemistry
55
1652-1662
2016
-
-
-
-
-
-
3
-
1
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3
-
1
-
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4
1
1
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1
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1
3
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1
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1
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1
3
3
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1
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3
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4
1
1
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1
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2
2
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744722
Morera
4-biphenylalanine- and 3-phen ...
Homo sapiens
ChemMedChem
11
2063-2083
2016
1
-
1
-
-
-
33
1
1
1
-
3
-
2
-
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1
1
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2
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5
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1
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1
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30
1
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1
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30
33
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1
1
1
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3
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1
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2
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5
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
744782
Pedanou
The histone H3K9 demethylase ...
Homo sapiens
eLife
5
e16844
2016
-
-
1
-
2
-
-
-
2
-
-
3
-
3
-
-
-
-
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5
-
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3
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1
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2
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2
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3
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5
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3
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2
3
3
2
-
-
744785
Pedersen
Continual removal of H3K9 pro ...
Mus musculus, Mus musculus C57BL/6
EMBO J.
35
1550-1564
2016
-
-
1
-
1
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-
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2
-
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10
-
5
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-
1
-
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10
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2
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3
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4
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10
-
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3
-
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10
-
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-
-
-
-
-
-
2
3
9
3
-
-
745525
Bavetsias
8-Substituted pyrido[3,4-d]py ...
Homo sapiens
J. Med. Chem.
59
1388-1409
2016
-
-
1
1
1
-
64
-
1
1
-
2
-
2
-
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1
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1
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1
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5
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2
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6
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1
3
3
1
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697241
Katz
A C. elegans LSD1 demethylase ...
Caenorhabditis elegans
Cell
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308-320
2009
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1
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1
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1
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1
1
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-
-
697546
Nottke
Developmental roles of the his ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Development
136
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2009
7
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3
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8
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7
7
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25
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7
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10
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45
2
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7
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10
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45
2
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2
7
7
2
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697557
Brasacchio
Hyperglycemia induces a dynami ...
Homo sapiens, Mus musculus
Diabetes
58
1229-1236
2009
2
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2
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4
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2
2
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-
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697672
Nicholson
LSD1 demethylates histone and ...
Mammalia
Epigenetics
4
129-132
2009
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7
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697909
Forneris
New roles of flavoproteins in ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
FEBS J.
276
4304-4312
2009
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13
1
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1
1
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698098
Lorbeck
The histone demethylase DmelKd ...
Drosophila melanogaster
Gene
450
8-17
2009
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1
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1
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1
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1
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698198
Magerl
H3K4 dimethylation in hepatoce ...
Homo sapiens
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41
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2009
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698910
Karytinos
A novel mammalian flavin-depen ...
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700164
Lee
The H3K4 demethylase lid assoc ...
Drosophila melanogaster
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1
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1
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1
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1
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1
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1
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2
1
1
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1
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1
1
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700361
Wang
The lysine demethylase LSD1 (K ...
Mus musculus
Nat. Genet.
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2009
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1
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2
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4
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1
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1
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2
2
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-
700397
Ciccone
KDM1B is a histone H3K4 demeth ...
Mus musculus
Nature
461
415-418
2009
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1
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2
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4
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1
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1
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1
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2
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700991
Hu
LSD1-mediated epigenetic modif ...
Mus musculus
Proc. Natl. Acad. Sci. USA
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10141-10146
2009
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2
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2
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1
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1
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2
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1
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2
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2
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1
1
1
1
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701212
Lan
Epigenetic regulation: methyla ...
Drosophila melanogaster
Sci. China C Life Sci.
52
311-322
2009
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4
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710874
Yang
Role of hypoxia-inducible fact ...
Homo sapiens
Ann. N. Y. Acad. Sci.
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185-197
2009
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6
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1
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1
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6
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1
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3
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711769
Huang
Novel oligoamine analogues inh ...
Homo sapiens
Clin. Cancer Res.
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3
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1
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13
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1
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3
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1
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713088
Liang
Inhibition of the histone deme ...
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1
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1
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1
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1
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684888
Mimasu
Crystal structure of histone d ...
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366
15-22
2008
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1
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3
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1
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1
1
1
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1
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2
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1
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3
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1
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684929
Wellmann
Hypoxia upregulates the histon ...
Homo sapiens, Rattus norvegicus
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892-897
2008
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689255
Lloret-Llinares
Characterization of Drosophila ...
Drosophila melanogaster
Nucleic Acids Res.
36
2852-2863
2008
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689713
Zhu
Lysine-specific demethylase 1 ...
Homo sapiens
PLoS ONE
3
e1446
2008
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1
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Seneda
Developmental regulation of hi ...
Sus scrofa
Reproduction
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829-838
2008
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3
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1
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696261
Spedaletti
Characterization of a lysine-s ...
Arabidopsis thaliana
Biochemistry
47
4936-4947
2008
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1
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4
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1
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6
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1
1
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1
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1
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1
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1
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4
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Reddy
Role of the lysine-specific de ...
Mus musculus
Circ. Res.
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615-623
2008
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1
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2
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Lan
Mechanisms involved in the reg ...
Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
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20
316-325
2008
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12
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12
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36
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21
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3
3
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698105
Pasini
Coordinated regulation of tran ...
Mus musculus
Genes Dev.
22
1345-1355
2008
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1
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2
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2
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1
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2
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1
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2
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1
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2
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1
1
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698354
Cui
Histone lysine methyltransfera ...
Plasmodium falciparum
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38
1083-1097
2008
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1
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1
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5
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699898
Chau
Cell cycle association of the ...
Homo sapiens
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82
3428-3437
2008
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1
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1
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1
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1
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1
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1
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1
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700154
Yokoyama
Transrepressive function of TL ...
Homo sapiens
Mol. Cell. Biol.
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2
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2
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1
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700158
Tsai
p53-targeted LSD1 functions in ...
Mus musculus
Mol. Cell. Biol.
28
5139-5146
2008
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1
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1
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1
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1
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1
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700159
Dey
The histone demethylase KDM5b/ ...
Mus musculus
Mol. Cell. Biol.
28
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2008
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1
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1
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1
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1
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1
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LSD1: oxidative chemistry for ...
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Jmjd1a and Jmjd2c histone H3 L ...
Mus musculus
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Specificity and mechanism of J ...
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689151
Ng
Crystal structures of histone ...
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Histone demethylase JHDM2A is ...
Mus musculus
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689709
Opel
Genome-wide studies of histone ...
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Lee
Histone H3 lysine 4 demethylat ...
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Culhane
A Mechanism-based inactivator ...
Homo sapiens
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Lee
Functional interplay between h ...
Homo sapiens
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670693
Chen
Crystal structure of human his ...
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2006
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Forneris
Histone demethylation catalyse ...
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