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show all sequences of 1.14.11.B1

Developmental roles of the histone lysine demethylases

Nottke, A.; Colaiacovo, M.; Shi, Y.; Development 136, 879-889 (2009)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
ascorbate
required
Arabidopsis thaliana
ascorbate
required
Caenorhabditis elegans
ascorbate
required
Mus musculus
ascorbate
required
Saccharomyces cerevisiae
ascorbate
required
Schizosaccharomyces pombe
ascorbate
required
Drosophila melanogaster
ascorbate
required
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
severe vulval defect in KDM5 mutants. rbr-2 mutants show a highly penetrant phenotype of either undeveloped or multiple vulvas, a phenotype reminiscent of the synthetic multivulva genes. But rbr-2 double mutants show no enhancement of phenotype with either class of synMuv mutant
Caenorhabditis elegans
additional information
mutation of LSD1/KDM1 leads to the disruption of heterochromatic/euchromatic boundary regions and to a disruption of germline development and meiotic processes. Su(var)3-3 null larvae show increased levels of H3K4me2. SU(VAR)3-3 mutants ahow a phenotype of female fertility defects together with H3K4me misregulation. Loss of LSD1/KDM1 causes embryonic lethality
Drosophila melanogaster
additional information
tissue-specific pituitary knockout of LSD1/KDM1 does not significantly influence pituitary gland development, but the mutants lack certain terminal differentiation- and cell-type-specific markers. General loss of LSD1/KDM1 causes embryonic lethality at an early embryonic stage. RNAi depletion of LSD1/KDM1 impairs the differentiation of several different mouse hematopoietic cell types, including erythroid and megakaryocyte cells, but also induces spontaneous granulocyte differentiation
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
bisguanidine
inhibits LSD1/KDM1
Arabidopsis thaliana
bisguanidine
inhibits LSD1/KDM1
Caenorhabditis elegans
bisguanidine
inhibits LSD1/KDM1
Drosophila melanogaster
bisguanidine
inhibits LSD1/KDM1
Homo sapiens
bisguanidine
inhibits LSD1/KDM1. Application of the chemical inhibitor, a polyamine analog, to in vitro fertilized mouse embryos not only increases global H3K4me2, but induces irreversible arrest at the two-cell stage
Mus musculus
bisguanidine
inhibits LSD1/KDM1
Saccharomyces cerevisiae
bisguanidine
inhibits LSD1/KDM1
Schizosaccharomyces pombe
yMYC
LID appears to interact with the cell growth regulator dMYC, which binds the jumonji domain of LID to inhibit its demethylase activity
Drosophila melanogaster
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleosome
-
Arabidopsis thaliana
786
-
nucleosome
-
Caenorhabditis elegans
786
-
nucleosome
-
Drosophila melanogaster
786
-
nucleosome
-
Mus musculus
786
-
nucleosome
-
Saccharomyces cerevisiae
786
-
nucleosome
-
Schizosaccharomyces pombe
786
-
nucleosome
-
Homo sapiens
786
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
required
Arabidopsis thaliana
Fe2+
required
Caenorhabditis elegans
Fe2+
required
Mus musculus
Fe2+
required
Saccharomyces cerevisiae
Fe2+
required
Schizosaccharomyces pombe
Fe2+
required
Drosophila melanogaster
Fe2+
required
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Drosophila melanogaster
genomic localization and function of histone demethylase substrates, overview. Trx proteins are gene activators with associated H3K4me3 methylation activity, one Trx group protein, LID, is a Drosophila KDM5 family homologue and an H3K4me3-specific demethylase, which represses transcription, overview
?
-
-
-
additional information
Mus musculus
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. In the activated somatotrope condition in anterior pituitary, LSD1/KDM1 and the H3K4me3 KMT MLL3/KMT2C are corecruited to the Gh promoter. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
?
-
-
-
additional information
Homo sapiens
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
?
-
-
-
additional information
Caenorhabditis elegans
levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis, H3K4me is present on the autosomes and is excluded from the silenced X chromosomes in both sexes
?
-
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Drosophila melanogaster
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Arabidopsis thaliana
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Schizosaccharomyces pombe
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Caenorhabditis elegans
KDM5 is responsible for global levels of H3K4me3 in later larval stages and adulthood
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Drosophila melanogaster
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Arabidopsis thaliana
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Schizosaccharomyces pombe
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Caenorhabditis elegans
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Drosophila melanogaster
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Arabidopsis thaliana
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Schizosaccharomyces pombe
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Caenorhabditis elegans
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
-
-
-
Caenorhabditis elegans
-
gene rbr-2 encoding the KDM5 homologue
-
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Saccharomyces cerevisiae
-
-
-
Schizosaccharomyces pombe
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
embryo
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Homo sapiens
-
embryo
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Mus musculus
-
embryonic stem cell
JMJD2C/KDM4C is preferentially expressed in undifferentiated embryonic stem cells, as compared with blastocysts and both hepatocyte and neural progenitor cells
Homo sapiens
-
embryonic stem cell
JMJD2C/KDM4C is preferentially expressed in undifferentiated embryonic stem cells, as compared with blastocysts and both hepatocyte and neural progenitor cells
Mus musculus
-
germ cell
-
Caenorhabditis elegans
-
germ cell
-
Drosophila melanogaster
-
larva
-
Drosophila melanogaster
-
oocyte
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Homo sapiens
-
oocyte
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Mus musculus
-
pituitary gland
high expression levels of LSD1 in adult gland
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
genomic localization and function of histone demethylase substrates, overview. Trx proteins are gene activators with associated H3K4me3 methylation activity, one Trx group protein, LID, is a Drosophila KDM5 family homologue and an H3K4me3-specific demethylase, which represses transcription, overview
697546
Drosophila melanogaster
?
-
-
-
-
additional information
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. In the activated somatotrope condition in anterior pituitary, LSD1/KDM1 and the H3K4me3 KMT MLL3/KMT2C are corecruited to the Gh promoter. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
697546
Mus musculus
?
-
-
-
-
additional information
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
697546
Homo sapiens
?
-
-
-
-
additional information
levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis, H3K4me is present on the autosomes and is excluded from the silenced X chromosomes in both sexes
697546
Caenorhabditis elegans
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Saccharomyces cerevisiae
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Arabidopsis thaliana
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Schizosaccharomyces pombe
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Caenorhabditis elegans
?
-
-
-
-
additional information
LSD1/KDM1 demethylates both di- and monomethylated K4, H3K4me2/1. Amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview. Enzyme substrates are located on insulators, active enhancers, active promoters, tissue-specific genes, and active chromatin
697546
Drosophila melanogaster
?
-
-
-
-
additional information
LSD1/KDM1 demethylates both di- and monomethylated K4, H3K4me2/1. Amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview. Enzyme substrates are located on insulators, active enhancers, active promoters, tissue-specific genes, and active chromatin
697546
Mus musculus
?
-
-
-
-
additional information
LSD1/KDM1 demethylates both di- and monomethylated K4, H3K4me2/1. Amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview. Enzyme substrates are located on insulators, active enhancers, active promoters, tissue-specific genes, and active chromatin
697546
Homo sapiens
?
-
-
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Homo sapiens
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Arabidopsis thaliana
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5 is responsible for global levels of H3K4me3 in later larval stages and adulthood
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Homo sapiens
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Arabidopsis thaliana
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Homo sapiens
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Arabidopsis thaliana
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
the enzymes are organized in enzyme complexes stabilizing and directing the enzyme activity in genes
Homo sapiens
More
the enzymes are organized in enzyme complexes stabilizing and directing the enzyme activity in genes
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
dependent on
Mus musculus
FAD
dependent on
Saccharomyces cerevisiae
FAD
dependent on
Schizosaccharomyces pombe
FAD
dependent on
Arabidopsis thaliana
FAD
dependent on
Caenorhabditis elegans
FAD
dependent on
Drosophila melanogaster
FAD
dependent on
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
ascorbate
required
Arabidopsis thaliana
ascorbate
required
Caenorhabditis elegans
ascorbate
required
Homo sapiens
ascorbate
required
Mus musculus
ascorbate
required
Saccharomyces cerevisiae
ascorbate
required
Schizosaccharomyces pombe
ascorbate
required
Drosophila melanogaster
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
dependent on
Mus musculus
FAD
dependent on
Saccharomyces cerevisiae
FAD
dependent on
Schizosaccharomyces pombe
FAD
dependent on
Arabidopsis thaliana
FAD
dependent on
Caenorhabditis elegans
FAD
dependent on
Drosophila melanogaster
FAD
dependent on
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
severe vulval defect in KDM5 mutants. rbr-2 mutants show a highly penetrant phenotype of either undeveloped or multiple vulvas, a phenotype reminiscent of the synthetic multivulva genes. But rbr-2 double mutants show no enhancement of phenotype with either class of synMuv mutant
Caenorhabditis elegans
additional information
mutation of LSD1/KDM1 leads to the disruption of heterochromatic/euchromatic boundary regions and to a disruption of germline development and meiotic processes. Su(var)3-3 null larvae show increased levels of H3K4me2. SU(VAR)3-3 mutants ahow a phenotype of female fertility defects together with H3K4me misregulation. Loss of LSD1/KDM1 causes embryonic lethality
Drosophila melanogaster
additional information
tissue-specific pituitary knockout of LSD1/KDM1 does not significantly influence pituitary gland development, but the mutants lack certain terminal differentiation- and cell-type-specific markers. General loss of LSD1/KDM1 causes embryonic lethality at an early embryonic stage. RNAi depletion of LSD1/KDM1 impairs the differentiation of several different mouse hematopoietic cell types, including erythroid and megakaryocyte cells, but also induces spontaneous granulocyte differentiation
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
bisguanidine
inhibits LSD1/KDM1
Arabidopsis thaliana
bisguanidine
inhibits LSD1/KDM1
Caenorhabditis elegans
bisguanidine
inhibits LSD1/KDM1
Drosophila melanogaster
bisguanidine
inhibits LSD1/KDM1
Homo sapiens
bisguanidine
inhibits LSD1/KDM1. Application of the chemical inhibitor, a polyamine analog, to in vitro fertilized mouse embryos not only increases global H3K4me2, but induces irreversible arrest at the two-cell stage
Mus musculus
bisguanidine
inhibits LSD1/KDM1
Saccharomyces cerevisiae
bisguanidine
inhibits LSD1/KDM1
Schizosaccharomyces pombe
yMYC
LID appears to interact with the cell growth regulator dMYC, which binds the jumonji domain of LID to inhibit its demethylase activity
Drosophila melanogaster
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleosome
-
Arabidopsis thaliana
786
-
nucleosome
-
Caenorhabditis elegans
786
-
nucleosome
-
Drosophila melanogaster
786
-
nucleosome
-
Mus musculus
786
-
nucleosome
-
Saccharomyces cerevisiae
786
-
nucleosome
-
Schizosaccharomyces pombe
786
-
nucleosome
-
Homo sapiens
786
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
required
Arabidopsis thaliana
Fe2+
required
Caenorhabditis elegans
Fe2+
required
Homo sapiens
Fe2+
required
Mus musculus
Fe2+
required
Saccharomyces cerevisiae
Fe2+
required
Schizosaccharomyces pombe
Fe2+
required
Drosophila melanogaster
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Drosophila melanogaster
genomic localization and function of histone demethylase substrates, overview. Trx proteins are gene activators with associated H3K4me3 methylation activity, one Trx group protein, LID, is a Drosophila KDM5 family homologue and an H3K4me3-specific demethylase, which represses transcription, overview
?
-
-
-
additional information
Mus musculus
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. In the activated somatotrope condition in anterior pituitary, LSD1/KDM1 and the H3K4me3 KMT MLL3/KMT2C are corecruited to the Gh promoter. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
?
-
-
-
additional information
Homo sapiens
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
?
-
-
-
additional information
Caenorhabditis elegans
levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis, H3K4me is present on the autosomes and is excluded from the silenced X chromosomes in both sexes
?
-
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Drosophila melanogaster
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Arabidopsis thaliana
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Schizosaccharomyces pombe
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Caenorhabditis elegans
KDM5 is responsible for global levels of H3K4me3 in later larval stages and adulthood
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Drosophila melanogaster
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Arabidopsis thaliana
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Schizosaccharomyces pombe
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
Caenorhabditis elegans
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Drosophila melanogaster
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Arabidopsis thaliana
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Schizosaccharomyces pombe
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
Caenorhabditis elegans
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
embryo
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Homo sapiens
-
embryo
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Mus musculus
-
embryonic stem cell
JMJD2C/KDM4C is preferentially expressed in undifferentiated embryonic stem cells, as compared with blastocysts and both hepatocyte and neural progenitor cells
Homo sapiens
-
embryonic stem cell
JMJD2C/KDM4C is preferentially expressed in undifferentiated embryonic stem cells, as compared with blastocysts and both hepatocyte and neural progenitor cells
Mus musculus
-
germ cell
-
Caenorhabditis elegans
-
germ cell
-
Drosophila melanogaster
-
larva
-
Drosophila melanogaster
-
oocyte
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Homo sapiens
-
oocyte
expression pattern in early mammalian development: the maternally stored transcript is no longer detectable by the maternal-to-embryo transition, when the embryo becomes transcriptionally competent. LSD1/KDM1 expression then recovers to oocyte levels by the blastula stage
Mus musculus
-
pituitary gland
high expression levels of LSD1 in adult gland
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
genomic localization and function of histone demethylase substrates, overview. Trx proteins are gene activators with associated H3K4me3 methylation activity, one Trx group protein, LID, is a Drosophila KDM5 family homologue and an H3K4me3-specific demethylase, which represses transcription, overview
697546
Drosophila melanogaster
?
-
-
-
-
additional information
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. In the activated somatotrope condition in anterior pituitary, LSD1/KDM1 and the H3K4me3 KMT MLL3/KMT2C are corecruited to the Gh promoter. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
697546
Mus musculus
?
-
-
-
-
additional information
H3K27me3 removal is functionally coordinated with H3K4me3 addition, physical association of an H3K27me3 demethylase with an H3K4me3 methyltransferase. Levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis. Depletion of depletion of JMJD2C/KDM4C alone leads to the increased expression of certain genes, including the endodermal lineage markers Gata4 and Gata6, while depletion of both JMJD2C/KDM4C and JHDM2A/KDM3A correlates with decreased levels of the pluripotency factors OCT4, SOX2 and NANOG. Model for LSD1/KDM1 regulation of estrogen receptor-induced gene expression, overview
697546
Homo sapiens
?
-
-
-
-
additional information
levels of H3K4me also show distinct and sometimes dramatic changes during early meiosis, H3K4me is present on the autosomes and is excluded from the silenced X chromosomes in both sexes
697546
Caenorhabditis elegans
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Saccharomyces cerevisiae
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Arabidopsis thaliana
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Schizosaccharomyces pombe
?
-
-
-
-
additional information
amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview
697546
Caenorhabditis elegans
?
-
-
-
-
additional information
LSD1/KDM1 demethylates both di- and monomethylated K4, H3K4me2/1. Amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview. Enzyme substrates are located on insulators, active enhancers, active promoters, tissue-specific genes, and active chromatin
697546
Drosophila melanogaster
?
-
-
-
-
additional information
LSD1/KDM1 demethylates both di- and monomethylated K4, H3K4me2/1. Amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview. Enzyme substrates are located on insulators, active enhancers, active promoters, tissue-specific genes, and active chromatin
697546
Mus musculus
?
-
-
-
-
additional information
LSD1/KDM1 demethylates both di- and monomethylated K4, H3K4me2/1. Amine oxidase-domain-containing mechanism and JmjC-domain-containing mechanism, overview. Enzyme substrates are located on insulators, active enhancers, active promoters, tissue-specific genes, and active chromatin
697546
Homo sapiens
?
-
-
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Homo sapiens
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Arabidopsis thaliana
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5 is responsible for global levels of H3K4me3 in later larval stages and adulthood
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
KDM5A-D
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Homo sapiens
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Arabidopsis thaliana
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Homo sapiens
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Arabidopsis thaliana
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
697546
Mus musculus
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
the enzyme is involved in dynamics during the early stages of meiotic prophase that correspond to chromosomal pairing, synapsis and the initiation/resolution of DNA double-strand breaks
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Drosophila melanogaster
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Saccharomyces cerevisiae
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Schizosaccharomyces pombe
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
LSD1
697546
Caenorhabditis elegans
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
the enzymes are organized in enzyme complexes stabilizing and directing the enzyme activity in genes
Homo sapiens
More
the enzymes are organized in enzyme complexes stabilizing and directing the enzyme activity in genes
Mus musculus
Expression
Organism
Commentary
Expression
Mus musculus
H3K4me shows a striking global upregulation at the start of male meiosis in mice, followed by a downregulation at the zygotene/pachytene stage
down
Mus musculus
H3K4me shows a striking global upregulation at the start of male meiosis in mice, followed by a downregulation at the zygotene/pachytene stage
up
General Information
General Information
Commentary
Organism
physiological function
histone demethylase regulation of developmental genes, overview
Arabidopsis thaliana
physiological function
histone demethylase regulation of developmental genes, overview
Caenorhabditis elegans
physiological function
Drosophila LSD1/KDM1 or SU(VAR)3-3 is a suppressor of heterochromatic silencing, histone demethylase regulation of developmental genes, overview
Drosophila melanogaster
physiological function
both H3K4me3 and H3K27me3 demethylases play key roles in neuronal development. Histone demethylase regulation of developmental genes, overview
Homo sapiens
physiological function
both H3K4me3 and H3K27me3 demethylases play key roles in neuronal development. Histone demethylase regulation of developmental genes, e.g. of HOX genes, overview. LSD1/KDM1 also plays a role in hematopoietic differentiation through interactions with the growth factor-independent proteins, which promote the expression of lineage-specific genes
Mus musculus
physiological function
histone demethylase regulation of developmental genes, overview
Saccharomyces cerevisiae
physiological function
histone demethylase regulation of developmental genes, overview
Schizosaccharomyces pombe
General Information (protein specific)
General Information
Commentary
Organism
physiological function
histone demethylase regulation of developmental genes, overview
Arabidopsis thaliana
physiological function
histone demethylase regulation of developmental genes, overview
Caenorhabditis elegans
physiological function
Drosophila LSD1/KDM1 or SU(VAR)3-3 is a suppressor of heterochromatic silencing, histone demethylase regulation of developmental genes, overview
Drosophila melanogaster
physiological function
both H3K4me3 and H3K27me3 demethylases play key roles in neuronal development. Histone demethylase regulation of developmental genes, overview
Homo sapiens
physiological function
both H3K4me3 and H3K27me3 demethylases play key roles in neuronal development. Histone demethylase regulation of developmental genes, e.g. of HOX genes, overview. LSD1/KDM1 also plays a role in hematopoietic differentiation through interactions with the growth factor-independent proteins, which promote the expression of lineage-specific genes
Mus musculus
physiological function
histone demethylase regulation of developmental genes, overview
Saccharomyces cerevisiae
physiological function
histone demethylase regulation of developmental genes, overview
Schizosaccharomyces pombe
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
H3K4me shows a striking global upregulation at the start of male meiosis in mice, followed by a downregulation at the zygotene/pachytene stage
down
Mus musculus
H3K4me shows a striking global upregulation at the start of male meiosis in mice, followed by a downregulation at the zygotene/pachytene stage
up
Other publictions for EC 1.14.11.B1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743916
Hancock
The activity of JmjC histone ...
Homo sapiens
ACS Chem. Biol.
12
1011-1019
2017
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1
1
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4
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2
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743984
Cai
Histone demethylase JMJD1C re ...
Homo sapiens
Am. J. Cancer Res.
7
115-124
2017
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1
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11
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1
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2
2
-
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744413
Maina
Histone demethylase PHF8 regu ...
Homo sapiens
Biochim. Biophys. Acta
1860
1002-1012
2017
-
-
-
-
1
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1
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1
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4
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2
2
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744494
Amano
Development and crystallograp ...
Homo sapiens
Bioorg. Med. Chem.
25
2617-2624
2017
-
-
-
1
-
-
15
-
-
-
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1
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15
13
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1
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1
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745030
Audonnet
JMJ24 antagonizes histone H3K ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Gene Expr. Patterns
25-26
1-7
2017
-
-
1
-
1
-
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4
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5
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4
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-
-
-
2
4
-
-
-
745752
Liu
LincRNAFEZF1-AS1 represses p2 ...
Homo sapiens
Mol. Cancer
16
39
2017
-
-
-
-
-
-
-
-
1
1
-
3
-
1
-
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3
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3
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1
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3
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3
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745771
Vyas
Lysine-specific demethylase-1 ...
Mus musculus
Mol. Cell. Neurosci.
82
1-11
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
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1
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-
-
-
-
-
-
2
2
-
-
-
745949
An
HistoneH3 demethylase JMJD2A ...
Homo sapiens
Oncotarget
8
49093-49109
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
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-
4
-
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1
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1
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1
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1
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4
-
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1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745951
Qin
The histone demethylase Kdm3a ...
Mus musculus
Oncotarget
8
84761-84775
2017
1
-
-
-
1
-
-
-
1
1
-
3
-
2
-
-
-
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5
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4
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5
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4
-
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-
-
-
-
-
-
-
3
3
-
-
-
746085
Dutta
JMJ27, an Arabidopsis H3K9 hi ...
Arabidopsis thaliana
Plant J.
91
1015-1028
2017
-
-
1
-
1
-
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1
1
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2
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3
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4
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4
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5
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1
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1
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1
3
3
1
-
-
746217
Jang
Histone H3K9 demethylase JMJD ...
Homo sapiens
PLoS ONE
12
e0168185
2017
-
-
1
-
1
-
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1
1
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2
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1
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3
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2
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4
4
-
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-
744236
Choi
KDM7A histone demethylase med ...
Homo sapiens
Biochem. Biophys. Res. Commun.
478
1355-1362
2016
-
-
1
-
1
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2
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2
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2
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1
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-
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2
2
-
-
-
744347
Burg
Lysine-specific demethylase 1 ...
Homo sapiens
Biochemistry
55
1652-1662
2016
-
-
-
-
-
-
3
-
1
-
-
3
-
1
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4
1
1
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1
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1
3
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1
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1
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1
3
3
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1
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3
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4
1
1
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-
-
1
-
-
-
-
2
2
-
-
-
744722
Morera
4-biphenylalanine- and 3-phen ...
Homo sapiens
ChemMedChem
11
2063-2083
2016
1
-
1
-
-
-
33
1
1
1
-
3
-
2
-
-
1
1
-
2
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5
-
1
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1
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30
1
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1
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-
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30
33
-
1
1
1
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3
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1
-
2
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5
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1
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-
-
1
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-
-
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2
2
-
-
-
744782
Pedanou
The histone H3K9 demethylase ...
Homo sapiens
eLife
5
e16844
2016
-
-
1
-
2
-
-
-
2
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3
-
3
-
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5
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3
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1
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5
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3
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-
2
3
3
2
-
-
744785
Pedersen
Continual removal of H3K9 pro ...
Mus musculus, Mus musculus C57BL/6
EMBO J.
35
1550-1564
2016
-
-
1
-
1
-
-
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2
-
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10
-
5
-
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-
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1
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10
-
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2
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3
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4
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10
-
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3
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10
-
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-
-
-
-
-
-
2
3
9
3
-
-
745525
Bavetsias
8-Substituted pyrido[3,4-d]py ...
Homo sapiens
J. Med. Chem.
59
1388-1409
2016
-
-
1
1
1
-
64
-
1
1
-
2
-
2
-
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1
-
-
2
-
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3
-
1
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1
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1
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1
1
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123
-
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2
2
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2
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1
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4
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3
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2
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2
-
-
-
-
-
-
-
-
-
745889
Yuan
KDM4C, a H3K9me3 histone deme ...
Homo sapiens
Neoplasia
18
594-609
2016
-
2
-
-
1
-
1
-
3
-
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1
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2
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-
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4
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1
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2
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1
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1
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4
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1
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-
-
-
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2
2
-
-
-
746196
Gu
The histone demethylase PHF8 ...
Homo sapiens
PLoS ONE
11
e0146645
2016
-
-
1
-
1
-
-
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1
-
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4
-
2
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3
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5
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1
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1
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4
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3
-
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5
-
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-
-
-
-
-
-
-
-
3
3
-
-
-
744863
Jiang
Histone H3K9 demethylase JMJD ...
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
FASEB J.
29
1830-1841
2015
-
-
2
-
2
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4
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7
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4
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4
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4
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4
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4
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-
-
-
-
-
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6
9
-
-
-
745102
Liu
The histone H3K9 demethylase ...
Mus musculus, Mus musculus C57BL/6
Int. J. Biol. Sci.
11
494-507
2015
-
-
-
-
1
-
-
-
-
-
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6
-
3
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4
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6
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6
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4
-
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6
-
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-
-
-
-
-
-
-
-
3
3
-
-
-
746537
Xiao
Cadmium induces histone H3 ly ...
Homo sapiens
Toxicol. Sci.
145
80-89
2015
1
-
-
-
-
-
1
-
2
1
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1
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2
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1
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1
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1
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1
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1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
744188
El Mansouri
Lysine-specific demethylase 1 ...
Homo sapiens
Arthritis Res. Ther.
16
R113
2014
1
-
1
-
1
-
2
-
2
1
-
2
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2
-
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2
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2
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3
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-
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-
-
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3
3
-
-
-
744224
Shen
The histone demethylase PHF8 ...
Homo sapiens
Biochem. Biophys. Res. Commun.
451
119-125
2014
-
-
1
-
1
-
-
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1
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3
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1
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4
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1
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3
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-
-
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-
-
-
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2
2
-
-
-
744861
Liu
Hairless is a histone H3K9 de ...
Homo sapiens
FASEB J.
28
1534-1542
2014
1
-
1
-
3
-
-
-
1
1
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3
-
3
-
-
-
-
-
6
-
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4
1
1
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1
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1
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1
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3
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1
1
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3
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6
-
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4
1
1
-
-
-
1
-
-
-
-
3
3
-
-
-
745917
Zoabi
RNA-dependent chromatin local ...
Homo sapiens
Nucleic Acids Res.
42
13026-13038
2014
1
-
1
-
1
-
-
1
2
1
-
1
-
1
-
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1
-
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1
-
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2
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The histone demethylase JMJD1 ...
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The testis-enriched histone de ...
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The histone demethylase JMJD2B ...
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Histone demethylase JMJD2B coo ...
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The histone demethylase JMJD2B ...
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Features of the PHF8/KIAA1718 ...
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1
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711823
Strobl-Mazzulla
Histone demethylase JmjD2A reg ...
Gallus gallus
Dev. Cell
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460-468
2010
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Gaweska
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Homo sapiens
Biochemistry
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2009
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3
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1
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1
1
1
1
1
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1
1
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1
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3
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1
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1
1
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3
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1
1
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1
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696434
Marmorstein
Histone modifying enzymes: str ...
Homo sapiens
Biochim. Biophys. Acta
1789
58-68
2009
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1
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1
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1
1
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1
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9
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697002
Kavi
Drosophila KDM2 is a H3K4me3 d ...
Drosophila melanogaster
BMC Res. Notes
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1
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-
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2
2
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697107
Schulte
Lysine-specific demethylase 1 ...
Homo sapiens
Cancer Res.
69
2065-2071
2009
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1
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1
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2
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6
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1
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1
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2
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5
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-
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2
-
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6
-
-
-
-
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-
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1
3
3
1
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697241
Katz
A C. elegans LSD1 demethylase ...
Caenorhabditis elegans
Cell
137
308-320
2009
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1
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1
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-
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1
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1
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1
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697546
Nottke
Developmental roles of the his ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Development
136
879-889
2009
7
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3
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10
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2
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7
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7
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7
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3
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7
7
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25
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10
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45
2
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2
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7
2
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697557
Brasacchio
Hyperglycemia induces a dynami ...
Homo sapiens, Mus musculus
Diabetes
58
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2009
2
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2
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4
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2
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4
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2
2
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697672
Nicholson
LSD1 demethylates histone and ...
Mammalia
Epigenetics
4
129-132
2009
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7
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4
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7
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1
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697909
Forneris
New roles of flavoproteins in ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
FEBS J.
276
4304-4312
2009
1
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1
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1
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9
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13
1
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1
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698098
Lorbeck
The histone demethylase DmelKd ...
Drosophila melanogaster
Gene
450
8-17
2009
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1
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1
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3
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1
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1
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1
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1
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1
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698198
Magerl
H3K4 dimethylation in hepatoce ...
Homo sapiens
Hum. Pathol.
41
181-189
2009
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1
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7
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Karytinos
A novel mammalian flavin-depen ...
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1
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6
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1
1
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6
8
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9
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700164
Lee
The H3K4 demethylase lid assoc ...
Drosophila melanogaster
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1
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1
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1
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670250
Lee
Functional interplay between h ...
Homo sapiens
Mol. Cell. Biol.
26
6395-6402
2006
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670693
Chen
Crystal structure of human his ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
13956-13961
2006
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668605
Forneris
Histone demethylation catalyse ...
Homo sapiens
FEBS Lett.
579
2203-2207
2005
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