Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94953 | ioform KDM4B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
ZR-75-30 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
KDM4B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in cancer cells, H3K9me3 is largely enriched in long interspersed nuclear element-1 (LINE-1). A significant proportion of KDM4B-dependent H3K9me3 is located in evolutionarily young LINE-1 elements, which likely retain retrotransposition activity. Ectopic expression of KDM4B promotes LINE-1 expression, while depletion of KDM4B reduces it. KDM4B overexpression enhances LINE-1 retrotransposition efficacy, copy number, and associated DNA damage. Breast cancer cell lines expressing high levels of KDM4B also exhibit increased LINE-1 expression and copy number compared with other cell lines. Pharmacologic inhibition of KDM4B significantly reduces LINE-1 expression and DNA damage in breast cancer cells with excessive KDM4B | Homo sapiens |