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Literature summary for 1.14.11.65 extracted from

  • Leisegang, M.; Gu, L.; Preussner, J.; Guenther, S.; Hitzel, J.; Ratiu, C.; Weigert, A.; Chen, W.; Schwarz, E.; Looso, M.; Fork, C.; Brandes, R.
    The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G (2019), FEBS Lett., 593, 487-498 .
    View publication on PubMed
Search for more literature for 1.14.11.65

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UPP1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PHF8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PHF8 interacts with U1 spliceosomal proteins, such as SRPK1 and snRNP70. The histocompatibility antigen HLA-G is a target of PHF8. The inclusion of HLA-G intron 4, with concomitant RNA Polymerase II accumulation at this intron is controlled by PHF8 and H3K9. Soluble HLA-G is generated after PHF8 knockdown, which leads to reduced T-cell proliferation Homo sapiens