Cloned (Comment) | Organism |
---|---|
gene PLOD2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[procollagen]-L-lysine + 2-oxoglutarate + O2 | Homo sapiens | - |
[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00469 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel | - |
Homo sapiens | - |
brain | PLOD2 is mainly expressed within the tunica media of the blood vessels | Homo sapiens | - |
additional information | PLOD2 expression determination by immunhistochemic analysis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[procollagen]-L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lysylhydroxylase 2 | - |
Homo sapiens |
PLOD2 | - |
Homo sapiens |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, PLOD2, is involved in the posttranscriptional modification of collagen molecules and considered as a key mediator of collagen cross-linking and thus an important factor for the stability of the extracellular matrix. PLOD2 is known to be associated with several connective tissue diseases, such as Ehlers-Danlos syndrome type VI A, systemic sclerosis, and Bruck syndrome. Isozyme PLOD2 is involved in the pathology of brain arteriovenous malformations (bAVM), severe conditions that can cause severe neurologic deficits and mortality. High levels of PLOD2 expression correlate with bAVM size. Although PLOD2 is not directly associated with bAVM hemorrhage, high PLOD2-expressing bAVM have a lower frequency of hemorrhage compared with low or medium PLOD2-expressing bAVM (25% vs. 63% and 75%, respectively) | Homo sapiens |