Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CO releasing molecule-2 | i.e.CORM-2, [RuCl2(CO)3]2, in situ CO donor, reduces the hydroxylation of C-terminal and N-terminal oxygen-dependent degradation domains of HIF-1alpha | Homo sapiens | |
RuCl3 | inhibitor of PHD2 under the standard assay conditions in presence of 10 microM Fe(II). This effect can be alleviated by supplementing the enzymatic reaction mixture with excess Fe(II) | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0052 | - |
DLDLEMLAPYIPMDDDFQL | pH 7.5, 37°C | Homo sapiens | |
0.0366 | - |
DALTLLAPAAGDTIISLDF | pH 7.5, 37°C | Homo sapiens | |
0.1071 | - |
DALTLLAPAAGDTIISLDF | pH 7.5, 37°C | Homo sapiens | |
0.1306 | - |
DLDLEMLAPYIPTIISLDF | pH 7.5, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9GZT9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DALTLLAPAAGDTIISLDF + 2-oxoglutarate + O2 | hybrid substrate derived from C-terminal and N-terminal oxygen-dependent degradation domain | Homo sapiens | DALTLLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLDF + succinate + CO2 | - |
? | |
DALTLLAPAAGDTIISLDF + 2-oxoglutarate + O2 | substrate derived from N-terminal oxygen-dependent degradation domain | Homo sapiens | DLDLEMLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLDF + succinate + CO2 | - |
? | |
DLDLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2 | substrate derived from C-terminal oxygen-dependent degradation domain | Homo sapiens | DLDLEMLA-((4R)-4-hydroxy-L-proline)-YIPMDDDFQL + succinate + CO2 | - |
? | |
DLDLEMLAPYIPTIISLDF + 2-oxoglutarate + O2 | hybrid substrate derived from C-terminal and N-terminal oxygen-dependent degradation domain | Homo sapiens | DLDLEMLA-((4R)-4-hydroxy-L-proline)-YIPTIISLDF + succinate + CO2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0244 | - |
substrate DLDLEMLAPYIPTIISLDF, pH 7.5, 37°C | Homo sapiens | CO releasing molecule-2 | |
0.0342 | - |
substrate DALTLLAPAAGDTIISLDF, pH 7.5, 37°C | Homo sapiens | CO releasing molecule-2 | |
0.0468 | - |
substrate DALTLLAPAAGDTIISLDF, pH 7.5, 37°C | Homo sapiens | CO releasing molecule-2 | |
0.1425 | - |
substrate DLDLEMLAPYIPMDDDFQL, pH 7.5, 37°C | Homo sapiens | CO releasing molecule-2 |