Activating Compound | Comment | Organism | Structure |
---|---|---|---|
fisetin | fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP expression is relatively low in PDAC and correlates with tumor stage and poor prognosis. Fisetin enhances the effect of chemotherapy on pancreatic cancer cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75164 | cf. EC 1.14.11.65, EC 1.14.11.69, EC 1.14.11.66 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BxPC-3 cell | - |
Homo sapiens | - |
HPC-Y5 cell | - |
Homo sapiens | - |
MiaPaCa-2 cell | - |
Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
KDM4A | - |
Homo sapiens |