Any feedback?
Literature summary for 1.14.11.16 extracted from
- Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-beta-hydroxylase (2020), Bioorg. Med. Chem., 28, 115675 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| N-terminally His6-tagged human AspH315-758 (His6-AspH315-758) is produced in Escherichia coli BL21 (DE3) cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (R)-gossypol | - |
Homo sapiens | |
| belinostat | - |
Homo sapiens |  |
| bleomycin A2 | - |
Homo sapiens | |
| midostaurin | - |
Homo sapiens | |
| mithramycin A | - |
Homo sapiens | |
| navitoclax | - |
Homo sapiens | |
| obatoclax | - |
Homo sapiens | |
| plicamycin | - |
Homo sapiens | |
| pyridine-2,4-dicarboxylic acid | - |
Homo sapiens | |
| tubacin | - |
Homo sapiens | |
| vemurafenib | - |
Homo sapiens | |
| venetoclax | - |
Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | Fe2+-dependent enzyme | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q12797 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide-L-aspartate + 2-oxoglutarate + O2 | the substrate is the synthetic thioether linked cyclic peptide hFX-CP101-119. It is designed based on 19 EGFD1 amino acid residues of the sequence of human coagulation factor X (hFX amino acids 101-119) | Homo sapiens | peptide-3-hydroxy-L-aspartate + succinate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aspartate/asparagine-beta-hydroxylase | - |
Homo sapiens |
| ASPH | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00002 | - |
pH 7.5, 20°C | Homo sapiens | pyridine-2,4-dicarboxylic acid | |
| 0.00025 | - |
pH 7.5, 20°C | Homo sapiens | (R)-gossypol | |
| 0.00103 | - |
pH 7.5, 20°C | Homo sapiens | navitoclax | |
| 0.0014 | - |
pH 7.5, 20°C | Homo sapiens | venetoclax | |
| 0.00147 | - |
pH 7.5, 20°C | Homo sapiens | bleomycin A2 | |
| 0.00338 | - |
pH 7.5, 20°C | Homo sapiens | vemurafenib | |
| 0.00412 | - |
pH 7.5, 20°C | Homo sapiens | tubacin | |
| 0.00749 | - |
pH 7.5, 20°C | Homo sapiens | belinostat | |
| 0.00943 | - |
pH 7.5, 20°C | Homo sapiens | midostaurin | |
| 0.0095 | - |
pH 7.5, 20°C | Homo sapiens | mithramycin A | |
| 0.0129 | - |
pH 7.5, 20°C | Homo sapiens | obatoclax | |
| 0.0132 | - |
pH 7.5, 20°C | Homo sapiens | plicamycin |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | upregulated on the cell surface of invasive cancer cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme catalyses the hydroxylation of Asp/Asn-residues of epidermal growth factor-like domains | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
