Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a possible target for treatment of diabetic kidney disease. MIOX enzyme inhibitor D-glucarate might be a potential therapeutic agent for the amelioration of diabetic kidney disease | Mus musculus |
medicine | the enzyme is a possible target for treatment of diabetic kidney disease. MIOX enzyme inhibitor D-glucarate might be a potential therapeutic agent for the amelioration of diabetic kidney disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene MIOX, quantitative enzyme expression analysis | Mus musculus |
gene MIOX, quantitative enzyme expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-glucarate | a MIOX inhibitor | Homo sapiens | |
D-glucarate | a MIOX inhibitor, D-glucarate normalizes reduced autophagy and mitophagy in tubules of STZ-induced diabetic mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
myo-inositol + O2 | Mus musculus | - |
D-glucuronate + H2O | - |
? | |
myo-inositol + O2 | Homo sapiens | - |
D-glucuronate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UGB7 | - |
- |
Mus musculus | Q9QXN5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HK-2 cell | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
renal tubule | MIOX is a tubular-specific enzyme | Mus musculus | - |
renal tubule | MIOX is a tubular-specific enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myo-inositol + O2 | - |
Mus musculus | D-glucuronate + H2O | - |
? | |
myo-inositol + O2 | - |
Homo sapiens | D-glucuronate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MIOX | - |
Mus musculus |
MIOX | - |
Homo sapiens |
Myo-inositol oxygenase | - |
Mus musculus |
Myo-inositol oxygenase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience | up |
Homo sapiens | upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience | up |
General Information | Comment | Organism |
---|---|---|
malfunction | upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations | Homo sapiens |
malfunction | upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations, D-glucarate normalizes reduced autophagy and mitophagy in tubules of STZ-induced diabetic mice | Mus musculus |
metabolism | a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease | Mus musculus |
metabolism | a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease | Homo sapiens |
physiological function | myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview | Mus musculus |
physiological function | myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview | Homo sapiens |