BRENDA - Enzyme Database show
show all sequences of 1.13.11.77

Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase Comparison with COX-1 and COX-2

Mashhadi, Z.; Boeglin, W.E.; Brash, A.R.; Biochim. Biophys. Acta 1851, 1346-1352 (2015)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(8,10,12-EEZ)-conjugated linoleic acid derivative
strong inhibition
Nostoc punctiforme
alpha-calendic acid
(8,10,12-ZEE)-conjugated linoleic acid derivative, strong inhibition
Nostoc punctiforme
alpha-eleostearic acid acid
(9,11,13-ZEE)-conjugated linoleic acid derivative, strong inhibition
Nostoc punctiforme
alpha-linolenic acid
13% inhibition
Nostoc punctiforme
beta-calendic acid
(8,10,12-EEE)-conjugated linoleic acid derivative, complete inhibition
Nostoc punctiforme
beta-eleostearic acid acid
(9,11,13-EEE)-conjugated linoleic acid derivative, complete inhibition
Nostoc punctiforme
catalpic acid
(9,11,13-EEZ)-conjugated linoleic acid derivative
Nostoc punctiforme
jacaric acid
(8,10,12-ZEZ)-conjugated linoleic acid derivative, low inhibition
Nostoc punctiforme
additional information
the enzyme is potently inhibted by 8,10,12- and 9,11,13-conjugated linoleic acid derivatives, found as impurities in the linoleic acid preparation from plant, overview
Nostoc punctiforme
oxidized linoleic acid
6% inhibition
Nostoc punctiforme
punicic acid
(9,11,13-ZEZ)-conjugated linoleic acid derivative
Nostoc punctiforme
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
linoleate + O2
Nostoc punctiforme
-
(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Nostoc punctiforme
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
linoleate + O2
-
744396
Nostoc punctiforme
(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(8,10,12-EEZ)-conjugated linoleic acid derivative
strong inhibition
Nostoc punctiforme
alpha-calendic acid
(8,10,12-ZEE)-conjugated linoleic acid derivative, strong inhibition
Nostoc punctiforme
alpha-eleostearic acid acid
(9,11,13-ZEE)-conjugated linoleic acid derivative, strong inhibition
Nostoc punctiforme
alpha-linolenic acid
13% inhibition
Nostoc punctiforme
beta-calendic acid
(8,10,12-EEE)-conjugated linoleic acid derivative, complete inhibition
Nostoc punctiforme
beta-eleostearic acid acid
(9,11,13-EEE)-conjugated linoleic acid derivative, complete inhibition
Nostoc punctiforme
catalpic acid
(9,11,13-EEZ)-conjugated linoleic acid derivative
Nostoc punctiforme
jacaric acid
(8,10,12-ZEZ)-conjugated linoleic acid derivative, low inhibition
Nostoc punctiforme
additional information
the enzyme is potently inhibted by 8,10,12- and 9,11,13-conjugated linoleic acid derivatives, found as impurities in the linoleic acid preparation from plant, overview
Nostoc punctiforme
oxidized linoleic acid
6% inhibition
Nostoc punctiforme
punicic acid
(9,11,13-ZEZ)-conjugated linoleic acid derivative
Nostoc punctiforme
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
linoleate + O2
Nostoc punctiforme
-
(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
linoleate + O2
-
744396
Nostoc punctiforme
(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
-
-
-
?
Other publictions for EC 1.13.11.77
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744582
Kim
Production of 10S-hydroxy-8(E ...
Nostoc punctiforme
Biotechnol. Lett.
39
133-139
2017
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744396
Mashhadi
Robust inhibitory effects of ...
Nostoc punctiforme
Biochim. Biophys. Acta
1851
1346-1352
2015
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11
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1
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745297
Brash
An ancient relative of cycloo ...
Nostoc punctiforme
J. Biol. Chem.
289
13101-13111
2014
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6
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3
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3
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3
725415
Martinez
Biochemical characterization o ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa 42A2
J. Biol. Chem.
285
9339-9345
2010
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1
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723962
Busquets
Isolation and characterization ...
Pseudomonas sp., Pseudomonas sp. 42A2
Antonie van Leeuwenhoek
85
129-139
2004
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7
3
1
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13
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7
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