Crystallization (Comment) | Organism |
---|---|
crystal structure analysis | Amycolatopsis orientalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | Amycolatopsis orientalis | - |
4-hydroxymandelate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Amycolatopsis orientalis | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 | HMS uses Fe(IV)=O to perform hydroxylation of the benzylic carbon, reaction mechanism with electrophilic attack on the aromatic ring, and HMS catalytic cycle, overview | Amycolatopsis orientalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | - |
Amycolatopsis orientalis | 4-hydroxymandelate + CO2 | - |
? | |
4-hydroxyphenylpyruvate + O2 | active site structure and 4-hydroxymandelate binding structure, overview | Amycolatopsis orientalis | 4-hydroxymandelate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HMS | - |
Amycolatopsis orientalis |
hydroxymandelate synthase | - |
Amycolatopsis orientalis |
General Information | Comment | Organism |
---|---|---|
additional information | molecular docking and modeling, molecular dynamics and simulations by classical molecular dynamics simulations, simulated HMS-Fe(IV)-O-HPA species, overview | Amycolatopsis orientalis |