Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
5-(methylamino)-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carbonitrile | - |
Homo sapiens | |
5-chloro-N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
6,6a,11,11a-tetrahydro[1]benzothiopyrano[4,3-b]indole | - |
Homo sapiens | |
ethyl 6-chloro-3-[(3S)-3-hydroxy-7-methyloctanoyl]-2,3-dihydro-1H-indole-2-carboxylate | - |
Homo sapiens | |
N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | - |
Homo sapiens | |
NDGA | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15296 | isoform Alox15B | - |
Homo sapiens | P16050 | isoform Alox15, cf. EC 1.13.11.31 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eosinophil | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-LOX-1 | - |
Homo sapiens |
15-LOX-2 | - |
Homo sapiens |
Alox15 | - |
Homo sapiens |
ALOX15B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000025 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | NDGA | |
0.000032 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | |
0.00009 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethyl 6-chloro-3-[(3S)-3-hydroxy-7-methyloctanoyl]-2,3-dihydro-1H-indole-2-carboxylate | |
0.000099 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide | |
0.0001 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide | |
0.000197 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6,6a,11,11a-tetrahydro[1]benzothiopyrano[4,3-b]indole | |
0.0002 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(methylamino)-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carbonitrile | |
0.00055 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-chloro-N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide |
General Information | Comment | Organism |
---|---|---|
physiological function | eosinophil-depleted neutrophils express the 15-lipoxygenase isoform 2 but not the 15-lipoxygenase -1, in contrast to eosinophils which express the 15-lipoxygenase-1 but not the 15-lipoxygenase-2. 15-lipoxygenase metabolite synthesis by neutrophils is not inhibited by the 15-LO-1 inhibitors BLX769, BLX3887, and ML351 | Homo sapiens |
physiological function | eosinophils express the 15-lipoxygenase-1 but not the 15-lipoxygenase-2. The synthesis of 15-lipoxygenase metabolites by neutrophils does not involve the 15-lipoxygenase-1 | Homo sapiens |