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Literature summary for 1.13.11.33 extracted from

  • Ali, S.A.; Awad, S.M.; Said, A.M.; Mahgoub, S.; Taha, H.; Ahmed, N.M.
    Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-lipoxygenase inhibitors (2020), J. Enzyme Inhib. Med. Chem., 35, 847-863 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.33

Inhibitors

Inhibitors Comment Organism Structure
3'-naphthalen-2-yl-1'-phenyl-5-p-tolyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid amide compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max
3'-naphthalen-2-yl-5,1'-diphenyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid amide compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max
3'-naphthalen-2-yl-5,1'-diphenyl-3,4-dihydro-2H,1'H-[3,4']bipyrazole compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max
3-(4-methoxyphenyl)-5-(3-naphthalen-2-yl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max
5-(3,4-dichlorophenyl)-3'-naphthalen-2-yl-1'-phenyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max
5-(3,4-dichlorophenyl)-3'-naphthalen-2-yl-2,1'-diphenyl-3,4-dihydro-2H,1'H-[3,4']-bipyrazole compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max
5-(3-naphthalen-2-yl-1-phenyl-1H-pyrazol-4-yl)-3-p-tolyl-4,5-dihydro-1,2-oxazole compound shows radical scavenging activity in comparison with ascorbic acid and 15-LOX inhibition potency Glycine max

Organism

Organism UniProt Comment Textmining
Glycine max
-
-
-

Synonyms

Synonyms Comment Organism
15-LOX
-
 Glycine max

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 pH 7.4, temperature not specified in the publication Glycine max 3'-naphthalen-2-yl-5,1'-diphenyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid amide
0.00157
-
 pH 7.4, temperature not specified in the publication Glycine max 5-(3,4-dichlorophenyl)-3'-naphthalen-2-yl-1'-phenyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid
0.0021
-
 pH 7.4, temperature not specified in the publication Glycine max 3'-naphthalen-2-yl-1'-phenyl-5-p-tolyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid amide
0.00223
-
 pH 7.4, temperature not specified in the publication Glycine max 3'-naphthalen-2-yl-5,1'-diphenyl-3,4-dihydro-2H,1'H-[3,4']bipyrazole
0.00353
-
 pH 7.4, temperature not specified in the publication Glycine max 5-(3,4-dichlorophenyl)-3'-naphthalen-2-yl-2,1'-diphenyl-3,4-dihydro-2H,1'H-[3,4']-bipyrazole
0.00423
-
 pH 7.4, temperature not specified in the publication Glycine max 5-(3-naphthalen-2-yl-1-phenyl-1H-pyrazol-4-yl)-3-p-tolyl-4,5-dihydro-1,2-oxazole
0.00437
-
 pH 7.4, temperature not specified in the publication Glycine max 3-(4-methoxyphenyl)-5-(3-naphthalen-2-yl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole