Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2,3-triphenylindolizine-7-carbonitrile | IC50: 0.028 mM | Glycine max | |
1-(1,3-dibenzyloxy-2-propyloxy)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.031 mM | Glycine max | |
1-(1-Hydroxy-1-phenyl-ethyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.017 mM | Glycine max | |
1-(1-hydroxyethyl)-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.026 mM | Glycine max | |
1-(2-furyl)-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.024 mM | Glycine max | |
1-(2-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.02 mM | Glycine max | |
1-(2-methoxyphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.029 mM | Glycine max | |
1-(3-chlorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.031 mM | Glycine max | |
1-(3-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.02 mM | Glycine max | |
1-(4-chlorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.031 mM | Glycine max | |
1-(4-fluorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.035 mM | Glycine max | |
1-(4-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.02 mM | Glycine max | |
1-(4-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.037mM | Oryctolagus cuniculus | |
1-(4-methoxyphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.032 mM | Glycine max | |
1-(4-methylphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.037 mM | Glycine max | |
1-(Cyclohexyl-hydroxy-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.023 mM | Glycine max | |
1-(Hydroxy-p-tolyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.022 mM | Glycine max | |
1-(Hydroxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.035 mM | Glycine max | |
1-(Hydroxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.048 mM | Oryctolagus cuniculus | |
1-(hydroxymethyl)-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.026 mM | Glycine max | |
1-(hydroxymethyl)-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.034 mM | Oryctolagus cuniculus | |
1-(Methoxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.021 mM | Glycine max | |
1-(methoxymethoxy)-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.031 mM | Glycine max | |
1-(methoxymethoxy)-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.075 mM | Oryctolagus cuniculus | |
1-acetyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.023 mM | Glycine max | |
1-acetyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.044 mM | Oryctolagus cuniculus | |
1-benzoyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.023 mM | Glycine max | |
1-benzoyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.043 mM | Oryctolagus cuniculus | |
1-benzyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.027 mM | Glycine max | |
1-benzyloxymethoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.027 mM | Glycine max | |
1-benzyloxymethoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.039 mM | Oryctolagus cuniculus | |
1-formyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.029 mM | Glycine max | |
1-formyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.061 mM | Oryctolagus cuniculus | |
1-methoxy-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.033 mM | Glycine max | |
1-methoxy-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.077 mM | Oryctolagus cuniculus | |
1-methyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.027 mM | Glycine max | |
1-methyl-2,3-diphenylindolizine-7-carbonitrile | IC50: 0.046 mM | Oryctolagus cuniculus | |
1-phenylmethoxy-2,3-diphenyl-7-indolizinecarbonitrile | IC50: 0.031 mM | Glycine max | |
1-[(4-Chloro-phenyl)-hydroxy-methyl]-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.023 mM | Glycine max | |
1-[Hydroxy-(4-methoxy-phenyl)-methyl]-2,3-diphenyl-indolizine-7-carbonitrile | IC50: 0.017 mM | Glycine max | |
2,3-diphenyl-1-(2-thienyl)indolizine-7-carbonitrile | IC50: 0.02 mM | Glycine max | |
2,3-diphenyl-1-(3-thienyl)indolizine-7-carbonitrile | IC50: 0.019 mM | Glycine max | |
2,3-diphenylindolizine-7-carbonitrile | IC50: 0.03 mM | Glycine max | |
2,3-diphenylindolizine-7-carbonitrile | IC50: 0.051 mM | Oryctolagus cuniculus | |
5-(methoxymethoxy)-6,7-diphenylpyrrolo[1,2-b]pyridazine | IC50: 0.032 mM | Glycine max | |
5-(methoxymethoxy)-6,7-diphenylpyrrolo[1,2-b]pyridazine | IC50: 0.059 mM | Oryctolagus cuniculus | |
5-ethoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | IC50: 0.028 mM | Glycine max | |
5-methoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | IC50: 0.029 mM | Glycine max | |
5-methoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | IC50: 0.059 mM | Oryctolagus cuniculus | |
6,7-diphenylpyrrolo[1,2-b]pyridazin-5-yl trifluoromethanesulfonate | IC50: 0.043 mM | Glycine max | |
7-cyano-2,3-diphenylindolizin-1-yl 2-methoxybenzoate | IC50: 0.03 mM | Glycine max | |
7-cyano-2,3-diphenylindolizin-1-yl 3-methoxybenzoate | IC50: 0.028 mM | Glycine max | |
7-cyano-2,3-diphenylindolizin-1-yl 4-methoxybenzoate | IC50: 0.028 mM | Glycine max | |
7-cyano-2,3-diphenylindolizin-1-yl trifluoromethanesulfonate | IC50: 0.046 mM | Glycine max | |
7-cyano-2,3-diphenylindolizin-1-yl trifluoromethanesulfonate | IC50: 0.059 mM | Oryctolagus cuniculus | |
Toluene-4-sulfonic acid 6,7-diphenyl-pyrrolo[1,2-b]pyridazin-5-yl ester | IC50: 0.017 mM | Glycine max | |
Toluene-4-sulfonic acid 6,7-diphenyl-pyrrolo[1,2-b]pyridazin-5-yl ester | IC50: 0.028 mM | Oryctolagus cuniculus | |
toluene-4-sulfonic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester | IC50: 0.017mM | Glycine max | |
toluene-4-sulfonic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester | IC50: 0.025 mM | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Oryctolagus cuniculus | the enzyme may be involved in the development of atherosclerosis | ? | - |
? | |
additional information | Glycine max | the enzyme may be involved in the development of atherosclerosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Glycine max | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
reticulocyte | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
linoleic acid + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
linoleic acid + O2 | - |
Glycine max | ? | - |
? | |
additional information | the enzyme may be involved in the development of atherosclerosis | Oryctolagus cuniculus | ? | - |
? | |
additional information | the enzyme may be involved in the development of atherosclerosis | Glycine max | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase | - |
Oryctolagus cuniculus |
15-lipoxygenase | - |
Glycine max |
15-LO | - |
Oryctolagus cuniculus |
15-LO | - |
Glycine max |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.017 | - |
IC50: 0.017 mM | Glycine max | Toluene-4-sulfonic acid 6,7-diphenyl-pyrrolo[1,2-b]pyridazin-5-yl ester | |
0.017 | - |
IC50: 0.017 mM | Glycine max | 1-(1-Hydroxy-1-phenyl-ethyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.017 | - |
IC50: 0.017 mM | Glycine max | 1-[Hydroxy-(4-methoxy-phenyl)-methyl]-2,3-diphenyl-indolizine-7-carbonitrile | |
0.017 | - |
IC50: 0.017mM | Glycine max | toluene-4-sulfonic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester | |
0.019 | - |
IC50: 0.019 mM | Glycine max | 2,3-diphenyl-1-(3-thienyl)indolizine-7-carbonitrile | |
0.02 | - |
IC50: 0.02 mM | Glycine max | 1-(4-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.02 | - |
IC50: 0.02 mM | Glycine max | 1-(3-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.02 | - |
IC50: 0.02 mM | Glycine max | 1-(2-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.02 | - |
IC50: 0.02 mM | Glycine max | 2,3-diphenyl-1-(2-thienyl)indolizine-7-carbonitrile | |
0.021 | - |
IC50: 0.021 mM | Glycine max | 1-(Methoxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.022 | - |
IC50: 0.022 mM | Glycine max | 1-(Hydroxy-p-tolyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.023 | - |
IC50: 0.023 mM | Glycine max | 1-acetyl-2,3-diphenylindolizine-7-carbonitrile | |
0.023 | - |
IC50: 0.023 mM | Glycine max | 1-benzoyl-2,3-diphenylindolizine-7-carbonitrile | |
0.023 | - |
IC50: 0.023 mM | Glycine max | 1-[(4-Chloro-phenyl)-hydroxy-methyl]-2,3-diphenyl-indolizine-7-carbonitrile | |
0.023 | - |
IC50: 0.023 mM | Glycine max | 1-(Cyclohexyl-hydroxy-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.024 | - |
IC50: 0.024 mM | Glycine max | 1-(2-furyl)-2,3-diphenylindolizine-7-carbonitrile | |
0.025 | - |
IC50: 0.025 mM | Oryctolagus cuniculus | toluene-4-sulfonic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester | |
0.026 | - |
IC50: 0.026 mM | Glycine max | 1-(1-hydroxyethyl)-2,3-diphenylindolizine-7-carbonitrile | |
0.026 | - |
IC50: 0.026 mM | Glycine max | 1-(hydroxymethyl)-2,3-diphenyl-7-indolizinecarbonitrile | |
0.027 | - |
IC50: 0.027 mM | Glycine max | 1-methyl-2,3-diphenylindolizine-7-carbonitrile | |
0.027 | - |
IC50: 0.027 mM | Glycine max | 1-benzyloxymethoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.027 | - |
IC50: 0.027 mM | Glycine max | 1-benzyl-2,3-diphenylindolizine-7-carbonitrile | |
0.028 | - |
IC50: 0.028 mM | Oryctolagus cuniculus | Toluene-4-sulfonic acid 6,7-diphenyl-pyrrolo[1,2-b]pyridazin-5-yl ester | |
0.028 | - |
IC50: 0.028 mM | Glycine max | 1,2,3-triphenylindolizine-7-carbonitrile | |
0.028 | - |
IC50: 0.028 mM | Glycine max | 5-ethoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | |
0.028 | - |
IC50: 0.028 mM | Glycine max | 7-cyano-2,3-diphenylindolizin-1-yl 4-methoxybenzoate | |
0.028 | - |
IC50: 0.028 mM | Glycine max | 7-cyano-2,3-diphenylindolizin-1-yl 3-methoxybenzoate | |
0.029 | - |
IC50: 0.029 mM | Glycine max | 1-formyl-2,3-diphenylindolizine-7-carbonitrile | |
0.029 | - |
IC50: 0.029 mM | Glycine max | 5-methoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | |
0.029 | - |
IC50: 0.029 mM | Glycine max | 1-(2-methoxyphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.03 | - |
IC50: 0.03 mM | Glycine max | 2,3-diphenylindolizine-7-carbonitrile | |
0.03 | - |
IC50: 0.03 mM | Glycine max | 7-cyano-2,3-diphenylindolizin-1-yl 2-methoxybenzoate | |
0.031 | - |
IC50: 0.031 mM | Glycine max | 1-(methoxymethoxy)-2,3-diphenylindolizine-7-carbonitrile | |
0.031 | - |
IC50: 0.031 mM | Glycine max | 1-phenylmethoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.031 | - |
IC50: 0.031 mM | Glycine max | 1-(4-chlorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.031 | - |
IC50: 0.031 mM | Glycine max | 1-(3-chlorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.031 | - |
IC50: 0.031 mM | Glycine max | 1-(1,3-dibenzyloxy-2-propyloxy)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.032 | - |
IC50: 0.032 mM | Glycine max | 5-(methoxymethoxy)-6,7-diphenylpyrrolo[1,2-b]pyridazine | |
0.032 | - |
IC50: 0.032 mM | Glycine max | 1-(4-methoxyphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.033 | - |
IC50: 0.033 mM | Glycine max | 1-methoxy-2,3-diphenylindolizine-7-carbonitrile | |
0.034 | - |
IC50: 0.034 mM | Oryctolagus cuniculus | 1-(hydroxymethyl)-2,3-diphenylindolizine-7-carbonitrile | |
0.035 | - |
IC50: 0.035 mM | Glycine max | 1-(Hydroxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.035 | - |
IC50: 0.035 mM | Glycine max | 1-(4-fluorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.037 | - |
IC50: 0.037 mM | Glycine max | 1-(4-methylphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.037 | - |
IC50: 0.037mM | Oryctolagus cuniculus | 1-(4-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.039 | - |
IC50: 0.039 mM | Oryctolagus cuniculus | 1-benzyloxymethoxy-2,3-diphenyl-7-indolizinecarbonitrile | |
0.043 | - |
IC50: 0.043 mM | Oryctolagus cuniculus | 1-benzoyl-2,3-diphenylindolizine-7-carbonitrile | |
0.043 | - |
IC50: 0.043 mM | Glycine max | 6,7-diphenylpyrrolo[1,2-b]pyridazin-5-yl trifluoromethanesulfonate | |
0.044 | - |
IC50: 0.044 mM | Oryctolagus cuniculus | 1-acetyl-2,3-diphenylindolizine-7-carbonitrile | |
0.046 | - |
IC50: 0.046 mM | Glycine max | 7-cyano-2,3-diphenylindolizin-1-yl trifluoromethanesulfonate | |
0.046 | - |
IC50: 0.046 mM | Oryctolagus cuniculus | 1-methyl-2,3-diphenylindolizine-7-carbonitrile | |
0.048 | - |
IC50: 0.048 mM | Oryctolagus cuniculus | 1-(Hydroxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile | |
0.051 | - |
IC50: 0.051 mM | Oryctolagus cuniculus | 2,3-diphenylindolizine-7-carbonitrile | |
0.059 | - |
IC50: 0.059 mM | Oryctolagus cuniculus | 7-cyano-2,3-diphenylindolizin-1-yl trifluoromethanesulfonate | |
0.059 | - |
IC50: 0.059 mM | Oryctolagus cuniculus | 5-methoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | |
0.059 | - |
IC50: 0.059 mM | Oryctolagus cuniculus | 5-(methoxymethoxy)-6,7-diphenylpyrrolo[1,2-b]pyridazine | |
0.061 | - |
IC50: 0.061 mM | Oryctolagus cuniculus | 1-formyl-2,3-diphenylindolizine-7-carbonitrile | |
0.075 | - |
IC50: 0.075 mM | Oryctolagus cuniculus | 1-(methoxymethoxy)-2,3-diphenylindolizine-7-carbonitrile | |
0.077 | - |
IC50: 0.077 mM | Oryctolagus cuniculus | 1-methoxy-2,3-diphenylindolizine-7-carbonitrile |