Literature summary for 1.13.11.33 extracted from

Walther, M.; Holzhutter, H.G.; Kuban, R.J.; Wiesner, R.; Rathmann, J.; Kuhn, H.
The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere (1999), Mol. Pharmacol., 56, 196-203.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-nitrocatechol	IC50: 0.0046 mM	Oryctolagus cuniculus
5,8,11,14-eicosatetraenoic acid	IC50: 0.00012 mM	Oryctolagus cuniculus
ebselen	i.e. 2-phenyl-1,2-benzisoselenazol-3(2H)-one, irreversible inhibition, IC50: 0.00006 mM	Oryctolagus cuniculus
linoleic acid	-	Oryctolagus cuniculus
N,2-dihydroxybenzamide	IC50: 0.057 mM	Oryctolagus cuniculus
nordihydroguaiaretic acid	IC50: 0.0005 mM	Oryctolagus cuniculus
PD 146 176	IC50: 0.00038 mM	Oryctolagus cuniculus
tert-butylhydroxyanisol	IC50: 0.16 mM	Oryctolagus cuniculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	contains 0.95 mol of iron per mol of enzyme	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
reticulocyte	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Oryctolagus cuniculus	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate	-	?
linoleic acid + O2	-	Oryctolagus cuniculus	13-hydroxylinoleic acid	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0041	-	linoleic acid	-	Oryctolagus cuniculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00006	-	i.e. 2-phenyl-1,2-benzisoselenazol-3(2H)-one, irreversible inhibition, IC50: 0.00006 mM	Oryctolagus cuniculus	ebselen
0.00012	-	IC50: 0.00012 mM	Oryctolagus cuniculus	5,8,11,14-eicosatetraenoic acid
0.00038	-	IC50: 0.00038 mM	Oryctolagus cuniculus	PD 146 176
0.0005	-	IC50: 0.0005 mM	Oryctolagus cuniculus	nordihydroguaiaretic acid
0.0046	-	IC50: 0.0046 mM	Oryctolagus cuniculus	4-nitrocatechol
0.057	-	IC50: 0.057 mM	Oryctolagus cuniculus	N,2-dihydroxybenzamide
0.16	-	IC50: 0.16 mM	Oryctolagus cuniculus	tert-butylhydroxyanisol

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Release 2023.1 (January 2023)