Crystallization (Comment) | Organism |
---|---|
structure in complex with inhibitor 2-benzyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione at a resolution of 1.8 A. The two carbonyl groups of 2-benzoylethen-1-ol formed a bidentate chelating interaction with the metal ion, while the isoindoline-1,3-dione moiety formes pronounced pi-pi stacking interactions with Phe381 and Phe424 | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-benzyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | showed the highest HPPD inhibitory activity of the compounds tested | Arabidopsis thaliana | |
2-[(2-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | - |
Arabidopsis thaliana | |
2-[(3-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | - |
Arabidopsis thaliana | |
2-[(4-bromo-2-fluorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | - |
Arabidopsis thaliana | |
2-[(4-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | - |
Arabidopsis thaliana | |
5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-[(3-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione | - |
Arabidopsis thaliana | |
mesotrione | - |
Arabidopsis thaliana | |
pyrasulfotole | - |
Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | P93836 | - |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000039 | - |
2-benzyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | pH not specified in the publication, 25°C | Arabidopsis thaliana | |
0.0000044 | - |
pyrasulfotole | pH not specified in the publication, 25°C | Arabidopsis thaliana | |
0.0000045 | - |
mesotrione | pH not specified in the publication, 25°C | Arabidopsis thaliana |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00009 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | 2-benzyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | |
0.0001 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | 2-[(3-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | |
0.0001 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-[(3-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione | |
0.00011 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | 2-[(2-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | |
0.00011 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | 2-[(4-bromo-2-fluorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | |
0.00012 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | 2-[(4-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione | |
0.00023 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | mesotrione | |
0.0014 | - |
pH not specified in the publication, 25°C | Arabidopsis thaliana | pyrasulfotole |