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Literature summary for 1.13.11.27 extracted from

  • Ndikuryayo, F.; Kang, W.M.; Wu, F.X.; Yang, W.C.; Yang, G.F.
    Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors (2019), Eur. J. Med. Chem., 166, 22-31 .
    View publication on PubMed
Search for more literature for 1.13.11.27

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-[3-[(2,4-dichlorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
-
 Homo sapiens
2-[3-[(2,4-difluorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
-
 Homo sapiens
2-[3-[(3,5-dimethylphenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
-
 Homo sapiens
2-[3-[(4-bromo-2-fluorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
-
 Homo sapiens
2-[3-[(4-bromophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
-
 Homo sapiens
2-[3-[(4-bromophenyl)methoxy]benzoyl]-3-hydroxycyclohex-2-en-1-one
-
 Homo sapiens
3-hydroxy-2-[3-[(4-isopropylphenyl)methoxy]-2-nitrobenzoyl]cyclohex-2-en-1-one
-
 Homo sapiens
3-hydroxy-2-[3-[(4-methylphenyl)methoxy]-2-nitrobenzoyl]cyclohex-2-en-1-one
-
 Homo sapiens
additional information hydrophobicity-oriented drug design strategy based on the interactions between HPPD and the commercial drug NTBC to idientify inhibitors Homo sapiens
nitisonone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P32754
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000047
-
 pH 7, 30°C Homo sapiens 2-[3-[(4-bromophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
0.000063
-
 pH 7, 30°C Homo sapiens 2-[3-[(2,4-dichlorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
0.000068
-
 pH 7, 30°C Homo sapiens 2-[3-[(3,5-dimethylphenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
0.000068
-
 pH 7, 30°C Homo sapiens 2-[3-[(4-bromo-2-fluorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one
0.00007
-
 pH 7, 30°C Homo sapiens 3-hydroxy-2-[3-[(4-isopropylphenyl)methoxy]-2-nitrobenzoyl]cyclohex-2-en-1-one
0.00007
-
 pH 7, 30°C Homo sapiens 3-hydroxy-2-[3-[(4-methylphenyl)methoxy]-2-nitrobenzoyl]cyclohex-2-en-1-one
0.000085
-
 pH 7, 30°C Homo sapiens nitisonone
0.000091
-
 pH 7, 30°C Homo sapiens 2-[3-[(4-bromophenyl)methoxy]benzoyl]-3-hydroxycyclohex-2-en-1-one
0.000095
-
 pH 7, 30°C Homo sapiens 2-[3-[(2,4-difluorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one