Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30041 | - |
- |
Mus musculus | O08709 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
peroxiredoxin 6 | - |
Homo sapiens |
peroxiredoxin 6 | - |
Mus musculus |
Prdx6 | - |
Homo sapiens |
Prdx6 | cf. EC 3.1.1.4 | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Mice that over-express Prdx6 show a greater increase in the growth of lung tumors compared to wild-type animals. Both aiPLA2 and Prdx6 peroxidase activities are implicated in lung tumor development through the regulation of redox-sensitive pathways such as MAPK, JNK, JAK/STAT, and AP-1 | Mus musculus |
physiological function | Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Prdx6 prevents oxidative stress in human retinal pigment epithelial cells by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway. Prdx6 is necessary to prevent cataract formation and to limit aging-induced oxidative stress in the eye | Homo sapiens |