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Literature summary for 1.11.1.24 extracted from

  • Jara, M.; Vivancos, A.P.; Calvo, I.A.; Moldon, A.; Sanso, M.; Hidalgo, E.
    The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast (2007), Mol. Biol. Cell, 18, 2288-2295.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.11.1.24

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain FB810 Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
C169S decreased activity Schizosaccharomyces pombe
C48S completely inactive Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
H2O2 high concentrations of H2O2 temporarily inactivate Tpx1 Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe O74887
-
-

Oxidation Stability

Oxidation Stability Organism
inactivation of Tpx1 by oxidation of its catalytic cysteine to a sulfinic acid is always preceded by a sulfinic acid form in a covalently linked dimer Schizosaccharomyces pombe

Purification (Commentary)

Purification (Comment) Organism
GSH-Sepharose 4B bead chromatography Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + reduced dithiothreitol
-
 Schizosaccharomyces pombe H2O + oxidized dithiothreitol
-
 ?
H2O2 + reduced thioredoxin
-
 Schizosaccharomyces pombe H2O + oxidized thioredoxin
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Schizosaccharomyces pombe

Synonyms

Synonyms Comment Organism
2-Cys peroxiredoxin
-
 Schizosaccharomyces pombe
TPx1
-
 Schizosaccharomyces pombe
two-cysteine peroxiredoxin
-
 Schizosaccharomyces pombe