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Literature summary for 1.1.5.4 extracted from

  • Wang, X.; Miyazaki, Y.; Inaoka, D.; Hartuti, E.; Watanabe, Y.; Shiba, T.; Harada, S.; Saimoto, H.; Burrows, J.; Benito, F.; Nozaki, T.; Kita, K.
    Identification of Plasmodium falciparum mitochondrial malate puinone oxidoreductase inhibitors from the pathogen box (2019), Genes (Basel), 10, 471 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.5.4

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in the Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
1,1'-[furan-2,5-diylbis(3-chloro-1,4-phenylene)]bisguanidine inhibits growth of cultured parasite Plasmodium falciparum
2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one inhibits growth of cultured parasite Plasmodium falciparum
2-[3-chloro-4-[5-[2-chloro-4-(diaminomethylideneamino)phenyl]furan-2-yl]phenyl]guanidine inhibits growth of cultured parasite Plasmodium falciparum
3-cycloheptyl-4abeta,5,8,8abeta-tetrahydro-1-[3-[4-[4-(2H-tetrazole-5-yl)phenoxy]butoxy]-4-methoxyphenyl]phthalazine-4(3H)-one inhibits growth of cultured parasite Plasmodium falciparum
3-[7-[(3,5-dimethylbenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl]propanoic acid
-
 Plasmodium falciparum
5-bromo-2-chloro-N-(5-mercapto-1,3,4-thiadiazol-2-yl)benzamide
-
 Plasmodium falciparum
N-[2-(1H-indol-3-yl)ethyl]-2-oxo-2H-chromene-3-carboxamide
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Plasmodium falciparum 5739
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum C6KT09 isolate 3D7
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + decylubiquinone
-
 Plasmodium falciparum oxaloacetate + decylubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
malate:quinone oxidoreductase
-
 Plasmodium falciparum
Mqo
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000726
-
 pH 7.0, 37°C Plasmodium falciparum 3-cycloheptyl-4abeta,5,8,8abeta-tetrahydro-1-[3-[4-[4-(2H-tetrazole-5-yl)phenoxy]butoxy]-4-methoxyphenyl]phthalazine-4(3H)-one
0.000343
-
 pH 7.0, 37°C Plasmodium falciparum 5-bromo-2-chloro-N-(5-mercapto-1,3,4-thiadiazol-2-yl)benzamide
0.001099
-
 pH 7.0, 37°C Plasmodium falciparum 2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one
0.00115
-
 pH 7.0, 37°C Plasmodium falciparum 1,1'-[furan-2,5-diylbis(3-chloro-1,4-phenylene)]bisguanidine
0.0036
-
 pH 7.0, 37°C Plasmodium falciparum 3-[7-[(3,5-dimethylbenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl]propanoic acid
0.00396
-
 pH 7.0, 37°C Plasmodium falciparum 2-[3-chloro-4-[5-[2-chloro-4-(diaminomethylideneamino)phenyl]furan-2-yl]phenyl]guanidine
0.00406
-
 pH 7.0, 37°C Plasmodium falciparum N-[2-(1H-indol-3-yl)ethyl]-2-oxo-2H-chromene-3-carboxamide

General Information

General Information Comment Organism
drug target the enzyme is a potential antimalarial drug target Plasmodium falciparum
physiological function the enzyme is involved in the pathways of mitochondrial electron transport chain, tricarboxylic acid cycle, and fumarate cycle. The enzyme is essential for the survival of Plasmodium falciparum in asexual stage Plasmodium falciparum