Literature summary for 1.1.3.9 extracted from

Johnson, H.C.; Zhang, S.; Fryszkowska, A.; Ruccolo, S.; Robaire, S.A.; Klapars, A.; Patel, N.R.; Whittaker, A.M.; Huffman, M.A.; Strotman, N.A.
Biocatalytic oxidation of alcohols using galactose oxidase and a manganese(III) activator for the synthesis of islatravir (2021), Org. Biomol. Chem., 19, 1620-1625 .

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Application

Application	Comment	Organism
synthesis	Mn(OAc)3 functions as a suitable activator for several commercially available variants of GOase with a series of alcohol substrates. Use of the Mn(OAc)3 additive is also compatible with biocatalytic synthesis of islatravir and subsequent biocatalytic steps in the islatravir-forming cascade	Fusarium graminearum

Organism

Organism	UniProt	Comment	Textmining
Fusarium graminearum	P0CS93	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(furan-2-yl)methanol + O2	-	Fusarium graminearum	furan-2-carbaldehyde + H2O2	-	?
2-ethynylglycerol + O2	-	Fusarium graminearum	(2R)-2-ethynylglyceraldehyde + H2O2	-	?
5-(hydroxymethyl)furan-2-carbaldehyde + O2	-	Fusarium graminearum	furan-2,5-dicarbaldehyde + H2O2	-	?

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Release 2023.1 (January 2023)