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Literature summary for 1.1.1.62 extracted from
- The regulation of hydroxysteroid 17beta-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer (2017), Oncotarget, 8, 62183-62194 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P37059 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell line | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HSD17B2 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | miRNA-204-5p, 498, 205-3p and 579-3p reduce HSD17B2 expression | down |
| Homo sapiens | dihydrotestosterone treatment increases HSD17B2 expression, with limited effect on HSD17B1 expression | up |
| Homo sapiens | downregulation of CX3CL1, EPHB6, and TP63 increases HSD17B1 and HSD17B2 expression | up |
| Homo sapiens | GREB1 downregulation promotes HSD17B2 expression | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | HSD17B2 is controlled by estradiol, dihydrotestosterone, and miRNAs, as well as modulated by several breast cancer related genes | Homo sapiens |
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