Application | Comment | Organism |
---|---|---|
diagnostics | enzyme NAD+-dependent isocitrate dehydrogenase cann act as a mitochondrial marker in asthenozoospermia | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | Homo sapiens | - |
2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spermatozoon | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate + NAD+ | - |
Homo sapiens | 2-oxoglutarate + CO2 + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterotetramer | (alpha)2betagamma | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
NAD+-dependent isocitrate dehydrogenase | - |
Homo sapiens |
NAD+-IDH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | IDH activity is increased in patients with prolonged cell phone daily use over 4 h/day. Its level correlates negatively with either the motility ratio percentages or the progressive motility percentages in the study groups. NAD+-IDH in human seminal plasma can be one of seminal plasma biomarkers reflecting the mitochondrial function of spermatozoa. Alteration of its level reflect the defective motility of sperms among some cases of cellular phone users | Homo sapiens |
metabolism | NAD-IDH is a key enzyme in the tricarboxylic acid cycle | Homo sapiens |