Cloned (Comment) | Organism |
---|---|
gene easD or fgaDH, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure | Aspergillus fumigatus |
gene easD, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure, DNA and amino acid sequence determination and comparison with the enzyme sequence from Penicilium biforme. The Penicillium camemberti genome contains a cluster of genes containing homologues to several eas genes and has or had (at one time in its evolutionary past) the ability to produce ergot alkaloids, expression analysis, the mRNAs are processed properly, as the cDNAs contain open reading frames, expression analysis | Penicillium camemberti |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
chanoclavine-I + NAD+ | Aspergillus fumigatus | - |
chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | Aspergillus fumigatus CBS 101355 | - |
chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | Aspergillus fumigatus ATCC MYA-4609 | - |
chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | Aspergillus fumigatus FGSC A1100 | - |
chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | Aspergillus fumigatus Af293 | - |
chanoclavine-I aldehyde + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | Q4WZ66 | Aspergillus fumigatus | - |
Aspergillus fumigatus Af293 | Q4WZ66 | Aspergillus fumigatus | - |
Aspergillus fumigatus ATCC MYA-4609 | Q4WZ66 | Aspergillus fumigatus | - |
Aspergillus fumigatus CBS 101355 | Q4WZ66 | Aspergillus fumigatus | - |
Aspergillus fumigatus FGSC A1100 | Q4WZ66 | Aspergillus fumigatus | - |
Penicillium camemberti | - |
- |
- |
Penicillium camemberti NRRL 874 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chanoclavine-I + NAD+ | - |
Penicillium camemberti | chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | - |
Aspergillus fumigatus | chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | - |
Aspergillus fumigatus CBS 101355 | chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | - |
Aspergillus fumigatus ATCC MYA-4609 | chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | - |
Aspergillus fumigatus FGSC A1100 | chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | - |
Aspergillus fumigatus Af293 | chanoclavine-I aldehyde + NADH + H+ | - |
r | |
chanoclavine-I + NAD+ | - |
Penicillium camemberti NRRL 874 | chanoclavine-I aldehyde + NADH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ChaDH | - |
Penicillium camemberti |
ChaDH | - |
Aspergillus fumigatus |
easD | - |
Penicillium camemberti |
easD | - |
Aspergillus fumigatus |
fgaDH | - |
Aspergillus fumigatus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Penicillium camemberti | |
NAD+ | - |
Aspergillus fumigatus | |
NADH | - |
Penicillium camemberti | |
NADH | - |
Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the biosynthesis of festuclavine from dimethylallylpyrosphosphate and tryptophane, the ergot alkaloid pathway, overview. The product of the easD reaction, chanoclavine-I aldehyde, serves as a branch point intermediate that may be acted on by the products of different alleles of ergot alkaloid synthesis genes in different lineages to yield lysergic acid and its derivatives in the Clavicipitaceae or various clavine-type ergot alkaloids in the Eurotiales (including Neosartorya and Penicillium species) | Penicillium camemberti |
metabolism | the enzyme is involved in the biosynthesis of festuclavine from dimethylallylpyrosphosphate and tryptophane, the ergot alkaloid pathway, overview. The product of the easD reaction, chanoclavine-I aldehyde, serves as a branch point intermediate that may be acted on by the products of different alleles of ergot alkaloid synthesis genes in different lineages to yield lysergic acid and its derivatives in the Clavicipitaceae or various clavine-type ergot alkaloids in the Eurotiales (including Neosartorya and Penicillium species) | Aspergillus fumigatus |
physiological function | the clavine alkaloids of the animal pathogen Neosartorya fumigata (Aspergillus fumigatus) contribute to virulence | Aspergillus fumigatus |