Inhibitors | Comment | Organism | Structure |
---|---|---|---|
quercetin | - |
Equus caballus | |
quercetin | - |
Homo sapiens | |
quercetin | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADPH + H+ | Equus caballus | - |
20beta-dihydrocortisol + NADP+ | - |
? | |
cortisol + NADPH + H+ | Homo sapiens | - |
20beta-dihydrocortisol + NADP+ | - |
? | |
cortisol + NADPH + H+ | Mus musculus | - |
20beta-dihydrocortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Equus caballus | - |
- |
- |
Homo sapiens | P16152 | - |
- |
Mus musculus | P48758 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Equus caballus | - |
adipose tissue | - |
Homo sapiens | - |
adipose tissue | - |
Mus musculus | - |
gut | - |
Equus caballus | - |
gut | - |
Mus musculus | - |
kidney | - |
Equus caballus | - |
kidney | - |
Mus musculus | - |
liver | - |
Equus caballus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADPH + H+ | - |
Equus caballus | 20beta-dihydrocortisol + NADP+ | - |
? | |
cortisol + NADPH + H+ | - |
Homo sapiens | 20beta-dihydrocortisol + NADP+ | - |
? | |
cortisol + NADPH + H+ | - |
Mus musculus | 20beta-dihydrocortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carbonyl reductase 1 | - |
Equus caballus |
carbonyl reductase 1 | - |
Homo sapiens |
carbonyl reductase 1 | - |
Mus musculus |
CBR1 | - |
Equus caballus |
CBR1 | - |
Homo sapiens |
CBR1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Equus caballus | the enzyme is up-regulated in adipose tissue in obesity | up |
Homo sapiens | the enzyme is up-regulated in adipose tissue in obesity | up |
Mus musculus | the enzyme is up-regulated in adipose tissue in obesity | up |
General Information | Comment | Organism |
---|---|---|
malfunction | pharmacological inhibition of carbonyl reductase 1 in diet-induced obesity in mice results in more marked glucose intolerance with evidence for enhanced hepatic glucocorticoid receptor signaling | Mus musculus |
metabolism | carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity | Equus caballus |
metabolism | carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity | Homo sapiens |
metabolism | carbonyl reductase 1 generating 20beta-dihydrocortisol is a pathway modulating glucocorticoid receptor activation and providing enzymatic protection against excessive GR activation in obesity | Mus musculus |