Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression is induced by interleukin-2 and interleukin-3 in thymocytes and bone marrow cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of gene disruption mutants by homologous recombination lacking enzyme expression and activity, the mutant female mice lack parturition on day 20 of pregnancy, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + NAD(P)H | Mus musculus | regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | high expression level | Mus musculus | - |
bone marrow | high expression level | Mus musculus | - |
kidney | high expression level | Mus musculus | - |
ovary | high expression level | Mus musculus | - |
thymus | high expression level | Mus musculus | - |
uterus | regulation of enzyme expression during pregnancy | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantification of serum progesterone levels | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + NAD(P)H | - |
Mus musculus | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r | |
17alpha-hydroxyprogesterone + NAD(P)H | regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview | Mus musculus | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
20alpha-HSD | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Mus musculus | |
NAD(P)H | - |
Mus musculus |