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Literature summary for 1.1.1.146 extracted from

  • Shearer, F.J.G.; Wyrwoll, C.S.; Holmes, M.C.
    The role of 11beta-hydroxy steroid dehydrogenase type 2 in glucocorticoid programming of affective and cognitive behaviours (2019), Neuroendocrinology, 109, 257-265 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NAD+ Mus musculus
-
 cortisone + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P51661
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
fetus
-
 Mus musculus
-
placenta
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+
-
 Mus musculus cortisone + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
11beta-hydroxy steroid dehydrogenase type 2
-
 Mus musculus
HSD2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction feto-placental deletion of isoform HSD2 results in a reduced birthweight and the development of anxiety- and depression-like behaviours in adult mice. Brain-specific HSD2 removal also generates adult phenotypes of depressive-like behaviour and memory deficits Mus musculus
physiological function isoform HSD2 expression protects the serotonin system in development Mus musculus