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Information on EC 7.5.2.6 - ABC-type lipid A-core oligosaccharide transporter and Organism(s) Salmonella typhimurium and UniProt Accession P63359

for references in articles please use BRENDA:EC7.5.2.6
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IUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
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This record set is specific for:
Salmonella typhimurium
UNIPROT: P63359
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
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ATP
+
H2O
+
lipopolysaccharide[side 1]
=
ADP
+
phosphate
+
lipopolysaccharide[side 2]
+
+
lipopolysaccharide[side 1]
=
+
+
lipopolysaccharide[side 2]
ATP
+
H2O
+
lipid A-core oligosaccharide[side 1]
=
ADP
+
phosphate
+
lipid A-core oligosaccharide[side 2]
+
+
lipid A-core oligosaccharide[side 1]
=
+
+
lipid A-core oligosaccharide[side 2]
Synonyms
msba2, msba protein, lipid a transporter, lps flippase, ecmsba, pa4997, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ATP-dependent lipid A-core flippase
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lipid flippase
-
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MsbA
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, lipid A-core oligosaccharide-translocating)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.