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IUBMB Comments A P-type ATPase that exports Ag+ + cf . EC 7.2.2.8 , P-type Cu+
Synonyms
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Ag+-exporting ATPase
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EC 3.6.3.53
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formerly
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ATP + H2O + Ag+[side 1] = ADP + phosphate + Ag+[side 2]
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hydrolysis of phosphoric ester
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transmembrane transport
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ATP phosphohydrolase (P-type, Ag+-exporting)
A P-type ATPase that exports Ag+ ions from some bacteria, archaea as well as from some animal tissues. The proteins also transport Cu+ ions (cf. EC 7.2.2.8, P-type Cu+ transporter).
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
ATP + H2O + Ag+[side 1]
ADP + phosphate + Ag+[side 2]
Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: removal of Ag+ from its site of toxic action, the gill
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: required for Ag+ resistance
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
ATP + H2O + Ag+[side 1]
ADP + phosphate + Ag+[side 2]
Substrates: -
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: removal of Ag+ from its site of toxic action, the gill
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ATP + H2O + Ag+/in
ADP + phosphate + Ag+/out
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Substrates: required for Ag+ resistance
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additional information
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mononesin, 0.01 mM, release transported Ag+ from the basolateral membrane vesicles
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cf. EC 7.2.2.8
UniProt
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gene is encoded by Ag+ resistance plasmid pMG101
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plasmid pKK1 specifies silver resistance
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K-12 strain J53(pMG101)
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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physiological function
the enzyme supports the detoxification of Ag and Cu, which is, besides efficient transport, the prerequisite for (hyper)accumulation
physiological function
the enzyme is involved in the delivery of physiological Cu into organelles of endomembrane system for the biosynthesis of Cu-dependent proteins
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SILP_SALTM
824
8
88221
Swiss-Prot
other Location (Reliability: 3 )
A0A2S1JL48_9AGAR
978
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105274
TrEMBL
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A0A2S1JL61_9AGAR
1097
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118260
TrEMBL
other Location (Reliability: 2 )
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additional information
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enzyme of the heavy-metal resistance efflux P-type ATPase family. The enzyme has a conserved aspartyl residues that is phosphorylated during the enzyme cycle, the ATP-binding region, the Thr-Gly-Glu-Ser phosphatase determinant, the Cys-Pro-Cys in the predicted sixth transmembrane alpha-helical region, and the His-Pro in the large aspartyl kinase domain between the phosphorylation site and the ATP binding region
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D555A
AsCCC2D555A cells show full growth on the YPEG medium supplemented with 1 mM Cu2+
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gene is encoded by Ag+ resistance plasmid pMG101
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expression in Saccharomyces cerevisiae
the gene is encoded by Ag+ resistance plasmid pMG101, the plasmid is transferred by conjugation to Escherichia coli, from which it is cloned
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treatments of mycelia with Ag+ and Cu+ elevates the expression of AsCRD1 relative to the unexposed control. The average levels of AsCRD1 transcripts increase 4.5- and 8.7-fold in the presence of 5 mM Ag+ and Cu2+, respectively, and they further nearly double when the concentration of the two metals is 50 mM
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Bury, N.R.; Grosell, M.; Grover, A.K.; Wood, C.M.
ATP-dependent silver transport across the basolateral membrane of rainbow trout gills
Toxicol. Appl. Pharmacol.
159
1-8
1999
Oncorhynchus mykiss
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Gupta, A.; Matsui, K.; Lo, J.F.; Silver, S.
Molecular basis for resistance to silver cations in Salmonella
Nature Med.
5
183-188
1999
Salmonella sp.
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Haefeli, C.; Franklin, C.; Hardy, K.
Plasmid-determined silver resistance in Pseudomonas stutzeri isolated from a silver mine
J. Bacteriol.
158
389-392
1984
Stutzerimonas stutzeri
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Gupta, A.; Maynes, M.; Silver, S.
Effects of halides on plasmid-mediated silver resistance in Escherichia coli
Appl. Environ. Microbiol.
64
5042-5045
1998
Escherichia coli
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Hendry, A.T.; Stewart, I.O.
Silver-resistant enterobacteriaceae from hospital patients
Can. J. Microbiol.
25
915-921
1979
Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter freundii
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Benes, V.; Leonhardt, T.; Sacky, J.; Kotrba, P.
Two P1B-1-ATPases of Amanita strobiliformis with distinct properties in Cu/Ag transport
Front. Microbiol.
9
747
2018
Amanita strobiliformis (A0A2S1JL61), Amanita strobiliformis (A0A2S1JL48)
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Transporter Classification Database (TCDB):
3.A.3.5.4
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