Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 6.3.3.1 - phosphoribosylformylglycinamidine cyclo-ligase and Organism(s) Escherichia coli and UniProt Accession P08178

for references in articles please use BRENDA:EC6.3.3.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.3 Cyclo-ligases
                6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Escherichia coli
UNIPROT: P08178 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Escherichia coli
The enzyme appears in selected viruses and cellular organisms
Synonyms
air synthetase, aminoimidazole ribonucleotide synthetase, phosphoribosylaminoimidazole synthetase, phosphoribosylformylglycinamidine cyclo-ligase, 5'-phosphoribosyl-5-aminoimidazole synthetase, phosphoribosyl-aminoimidazole synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminoimidazole ribonucleotide synthetase
-
5'-Aminoimidazole ribonucleotide synthetase
-
-
-
-
5'-Phosphoribosyl-5-aminoimidazole synthetase
-
-
-
-
AIR synthase
-
-
-
-
AIR synthetase
-
-
-
-
AIRS
-
-
-
-
Phosphoribosyl-aminoimidazole synthetase
-
-
-
-
Phosphoribosylaminoimidazole synthetase
-
-
-
-
Synthetase, phosphoribosylaminoimidazole
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9023-53-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
show the reaction diagram
-
-
?
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine
ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
show the reaction diagram
-
ATP in form of MgATP2-
-
-
?
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
?
show the reaction diagram
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
show the reaction diagram
ATPgammaS + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
ADP + ? + 1-(5-phosphoribosyl)-5-aminoimidazole
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
?
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
fluorosulfonylbenzoyl adenosine
FSBA, time-dependent inactivation by covalent binding to Lys27
1-(5-phosphoribosyl)-5-aminoimidazole
-
-
phosphate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012 - 0.073
ATP
0.027
2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
-
0.065
ATP
-
-
0.172
ATPgammaS
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
fluorosulfonylbenzoyl adenosine
15°C, pH 7.7
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36726
-
x * 36726, calculation from nucleotide sequence
38500
-
2 * 38500, SDS-PAGE
71700
-
gel filtration, sucrose density gradient ultracentrifugation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 36726, calculation from nucleotide sequence
dimer
-
2 * 38500, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K27L
obtained by site-directed mutagenesis and expression in Escherichia coli
K27Q
obtained by site-directed mutagenesis and expression in Escherichia coli
K27R
obtained by site-directed mutagenesis and expression in Escherichia coli
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purification of wild type and recombinant enzymes using C8-linked ATP affinity column
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of recombinant enzymes in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Smith, J.M.; Daum III, H.A.
Nucleotide sequence of the purM gene encoding 5'-phosphoribosyl-5-aminoimidazole synthetase of Escherichia coli K12
J. Biol. Chem.
261
10632-10636
1986
Escherichia coli
Manually annotated by BRENDA team
Schrimsher, J.L.; Schendel, F.J.; Stubbe, J.; Smith, J.M.
Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli
Biochemistry
25
4366-4371
1986
Escherichia coli
Manually annotated by BRENDA team
Mueller, E.J.; Oh, S.; Kavalerchik, E.; Kappock, T.J.; Meyer, E.; Li, C.; Ealick, S.E.; Stubbe, J.
Investigation of the ATP Binding Site of Escherichia coli Aminoimidazole Ribonucleotide Synthetase Using Affinity Labeling and Site-Directed Mutagenesis
Biochemistry
38
9831-9839
1999
Escherichia coli (P08178), Escherichia coli
Manually annotated by BRENDA team