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Information on EC 6.2.1.41 - 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-CoA ligase

for references in articles please use BRENDA:EC6.2.1.41

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IUBMB Comments

The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol and cholate. The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
fadd3, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
androstenedione degradation I (aerobic), androstenedione degradation II (anaerobic)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links