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Disease on EC 5.6.1.7 - chaperonin ATPase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
First case of Nocardia nova spinal abscess in an immunocompetent patient.
Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures.
Acne Vulgaris
Antibodies to mycobacterial 65-kDa heat shock protein and other immunodominant antigens in patients with psoriasis.
Acquired Immunodeficiency Syndrome
A comparison of the GroE chaperonin requirements for sequentially and structurally homologous malate dehydrogenases: the importance of folding kinetics and solution environment.
Description of a novel Mycobacterium simiae allelic variant isolated from Caribbean AIDS patients by PCR-restriction enzyme analysis and sequencing of hsp65 gene.
Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis.
N-terminal Gly(224)-Gly(411) domain in Listeria adhesion protein interacts with host receptor Hsp60.
PCR-restriction enzyme analysis of a bone marrow isolate from a human immunodeficiency virus-positive patient discloses polyclonal infection with two Mycobacterium avium strains.
Acute Coronary Syndrome
Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes.
Human heat shock protein 60 (409-424) fragment is recognized by serum antibodies of patients with acute coronary syndromes.
Acute Kidney Injury
Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients, Egyptian multicenter experience.
Acute Lung Injury
[Effects of over-expressing heat shock protein 60 on marrow mesenchymal stem cells in the treatment of phosgene-induced acute lung injury].
Adenocarcinoma
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
[Proteome analysis of autoantibodies in sera of patients with cancer]
Adenocarcinoma of Lung
Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
Adenoma
60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Albuminuria
Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice.
Alveolar Bone Loss
Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria.
Alzheimer Disease
Amyloid ? cytotoxicity is enhanced or reduced depending on formation of amyloid ? oligomeric forms.
Probing the mechanism of inhibition of amyloid-?(1-42)-induced neurotoxicity by the chaperonin GroEL.
Ameloblastoma
Overexpression and extra-mitochondrial localization of the chaperonin Hsp60 in ameloblastoma.
Amyotrophic Lateral Sclerosis
[Target antigens in neuroimmunological diseases]
Angina, Unstable
Prevalence of intimal heat shock protein 60 homologues in unstable angina and correlation with anti-heat shock protein antibody titers.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Evaluation of antibodies against human HSP60 in patients with MPO-ANCA associated glomerulonephritis: a cohort study.
Aortic Aneurysm, Abdominal
Chlamydia pneumoniae in abdominal aortic aneurysms: abundance of membrane components in the absence of heat shock protein 60 and DNA.
Aortic Valve Stenosis
Persistence of Chlamydia pneumoniae in degenerative aortic valve stenosis indicated by heat shock protein 60 homologues.
Arteriosclerosis
Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice.
Arthritis
A 12-kDa protein of Mycobacterium tuberculosis protects mice against experimental autoimmune encephalomyelitis. Protection in the absence of shared T cell epitopes with encephalitogenic proteins.
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response.
A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis.
Adjuvant arthritis and immunity to the mycobacterial 65 kDa heat shock protein.
An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis.
Anti-Hsp65 antibodies recognize M proteins of group A streptococci.
Antibodies against M. Bovis 65 KDa Heat Shock Protein and Its P180-188 Epitope in Sera of Patients with Juvenile Idiopathic Arthritis.
Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia.
Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis.
Arthritis transferred by cells derived from pre-inflammatory rat synovium.
Autoimmune reactions to heat-shock proteins in pristane-induced arthritis.
Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes.
Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide.
CD4+ Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced arthritis.
Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in pristane induced arthritis susceptible and hsp65 protected DBA/1 mice.
Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60.
Differential effects of immunisation with mycobacterial 65 kD heat shock protein on two models of autoimmunity.
Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.
Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic.
DNAhsp65 vaccination induces protection in mice against Paracoccidioides brasiliensis infection.
Expression of Mycobacterium leprae HSP65 in tobacco and its effectiveness as an oral treatment in adjuvant-induced arthritis.
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis.
Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis.
Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?
Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis.
HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration.
Hsp65-Producing Lactococcocus lactis Prevents Antigen-Induced Arthritis in Mice.
Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins.
Inflammation activates self hsp60-specific T cells.
Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein.
Modulation of Adjuvant Arthritis by Cellular and Humoral Immunity to Hsp65.
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis.
Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis.
Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis.
Peripheral blood mononuclear cell responses to heat shock proteins and their derived synthetic peptides in juvenile idiopathic arthritis patients.
Pristane-induced arthritis in mice selected for maximal or minimal acute inflammatory reaction.
Recombinant mycobacterial HSP65 in combination with incomplete Freund's adjuvant induced rat arthritis comparable with that induced by complete Freund's adjuvant.
Self heat-shock protein 65-mediated regulation of autoimmune arthritis.
Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis.
Susceptibility to pristane-induced arthritis is altered with changes in bowel flora.
T and B cell responses to mycobacterial 65-kDa heat-shock protein in sheep infected with maedi visna virus.
The Involvement of Heat-Shock Proteins in the Pathogenesis of Autoimmune Arthritis: A Critical Appraisal.
The role of oil and agalactosyl IgG in the induction of arthritis in rodent models.
The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts.
Tolerance to an arthritogenic T-cell epitope of HSP65 and the regulation of experimental arthritis.
Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses.
Treatment of adjuvant-induced arthritis by oral administration of mycobacterial Hsp65 during disease.
Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis.
[Autoimmune hepatitis]
Arthritis, Experimental
A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis.
A constitutive 65 kDa chondrocyte protein as a target antigen in adjuvant arthritis in Lewis rats.
Anti-Hsp65 antibodies recognize M proteins of group A streptococci.
Cellular and humoral reactivity pattern to the mycobacterial heat shock protein HSP65 in adjuvant arthritis susceptible and resistant Wistar rats.
Cellular immunity to cartilage link protein in patients with inflammatory arthritis and non-arthritic controls.
Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60.
Generation and characterization of a clonotypic antibody specific for the T cell receptor of an arthritogenic T cell clone--studies in adjuvant arthritis.
Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis.
Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis.
Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60.
Modulation of Adjuvant Arthritis by Cellular and Humoral Immunity to Hsp65.
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis.
Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65.
Self heat-shock protein 65-mediated regulation of autoimmune arthritis.
[Possible roles of infections and heat shock proteins in rheumatoid arthritis]
Arthritis, Juvenile
Antibodies against M. Bovis 65 KDa Heat Shock Protein and Its P180-188 Epitope in Sera of Patients with Juvenile Idiopathic Arthritis.
Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide.
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis.
Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?
Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity.
Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein.
Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis.
Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis.
Arthritis, Reactive
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60.
The humoral immune response to Chlamydia trachomatis in patients with acute reactive arthritis.
Arthritis, Rheumatoid
A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis.
Agalactosyl IgG, antibodies to heat shock proteins, and acute rheumatic fever.
Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis.
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Cellular immunity to cartilage link protein in patients with inflammatory arthritis and non-arthritic controls.
Chaperonin 10 for rheumatoid arthritis.
Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60.
Do heat-shock proteins (Hsps)65-reactive lymphocytes in rheumatoid arthritis, Hashimoto's thyroiditis & systemic lupus erythematosus implicate Hsp65 in autoimmunity?
Hsp60 and Hsp10 as Antitumor Molecular Agents.
Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein.
Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: results from a study of disease discordant twin pairs.
Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial.
XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator.
Asthma
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60.
Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults.
Chlamydia pneumoniae infection and inflammation in adults with asthma.
Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma.
Astrocytoma
Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas.
Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Interferon-gamma-induced expressions of heat shock protein 60 and heat shock protein 10 in C6 astroglioma cells: identification of the signal transducers and activators of transcription 3-binding site in bidirectional promoter.
NO-induced downregulation of HSP10 and HSP60 expression in the postischemic brain.
Ataxia Telangiectasia
Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription.
Atherosclerosis
A new murine model for atherosclerosis with inflammation in the periodontal tissue induced by immunization with heat shock protein 60.
A potent multivalent vaccine for modulation of immune system in atherosclerosis: an in silico approach.
A Th2 immune shift to heat shock protein 65 fails to arrest atherosclerosis: Proatherogenic role of Th2-deviated autoantibodies.
Antimycobacterial hsp65 and rheumatoid factor titres in a population of normal twins: evidence of genetic control of rheumatoid factor.
ApoB-100 and HSP60 Peptides Exert a Synergetic Role in Inhibiting Early Atherosclerosis in Immunized ApoE-null Mice.
Association of serum antibodies to heat-shock protein 65 with borderline hypertension.
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis.
Atheroprotective nasal immunization with a heat shock protein 60 peptide from Porphyromonas gingivalis.
Autoimmune and inflammatory mechanisms in atherosclerosis.
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.
Characterization of heat shock protein-specific T cells in atherosclerosis.
Characterization of human anti-heat shock protein 60 monoclonal autoantibody Fab fragments in atherosclerosis: Genetic and functional analysis.
Chlamydia heat shock protein 60 decreases expression of eNOS in human and porcine coronary artery endothelial cells.
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway.
Chlamydial heat shock protein 60 and lipopolysaccharide: potential virulence determinants in atherogenesis.
Chlamydial virulence determinants in atherogenesis: the role of chlamydial lipopolysaccharide and heat shock protein 60 in macrophage-lipoprotein interactions.
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis.
Elevated Anti-Heat Shock Protein 60 Antibody Titer is Related to White Matter Hyperintensities.
Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.
Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs.
Expression levels of heat shock protein 60 in human endothelial cells in vitro are unaffected by exposure to 50 Hz magnetic fields.
GroEL1, a Heat Shock Protein 60 of Chlamydia pneumoniae, Induces Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Expression in Endothelial Cells and Enhances Atherogenesis in Hypercholesterolemic Rabbits.
Heat shock protein 60 and immune inflammatory responses in atherosclerosis.
Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection.
Heat shock protein 70 and antibodies to heat shock protein 60 are associated with cerebrovascular atherosclerosis.
HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration.
Identification of immunoreactive epitopes of the Porphyromonas gingivalis heat shock protein in periodontitis and atherosclerosis.
Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients.
Immunity to heat shock protein 65--an additional determinant in intimal thickening.
Immunologic response enhances atherosclerosis-type 1 helper T cell (Th1)-to-type 2 helper T cell (Th2) shift and calcified atherosclerosis in Bacillus Calmette-Guerin (BCG)-treated apolipoprotein E-knockout (apo E-/-) mice.
Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.
Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients.
In silico analyses of heat shock protein 60 and calreticulin to designing a novel vaccine shifting immune response toward T helper 2 in atherosclerosis.
Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65.
Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study.
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Is atherosclerosis an immunologically mediated disease?
Mycobacterial heat shock protein 65 (mbHSP65)-induced atherosclerosis: Preventive oral tolerization and definition of atheroprotective and atherogenic mbHSP65 peptides.
Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response.
Nasal immunization with different forms of heat shock protein-65 reduced high-cholesterol-diet-driven rabbit atherosclerosis.
Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms.
Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.
Network of vascular-associated dendritic cells in intima of healthy young individuals.
Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice.
Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions.
Oral Tolerization with Mycobacterial Heat Shock Protein 65 Reduces Chronic Experimental Atherosclerosis in Aged Mice.
Porphyromonas gingivalis HSP60 peptides have distinct roles in the development of atherosclerosis.
Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis.
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population.
Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera.
Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.
T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis.
T-cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T-cell receptor repertoire.
The autoimmune concept of atherosclerosis.
The relationship between HSP60 gene polymorphisms and susceptibility to atherosclerosis.
The role of (auto-) immunity in atherogenesis.
The vascular-associated lymphoid tissue: a new site of local immunity.
Tolerization against atherosclerosis using heat shock protein 60.
Vaccination for atherosclerosis: a novel therapeutic paradigm.
Yangyin Qingre Huoxue Method in Traditional Chinese Medicine Ameliorates Atherosclerosis in ApoE-/- Mice Suffering from High-Fat Diet and HSP65 Aggression.
[Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link between infection and atherosclerosis]
Atrial Fibrillation
Expression of mortalin in patients with chronic atrial fibrillation.
Heat shock protein 60 antibody. A new marker for subsequent atrial fibrillation development.
Overexpression of heat shock protein 60/10 in myocardium of patients with chronic atrial fibrillation.
The expression of heat shock protein 60 in myocardium of patients with chronic atrial fibrillation.
Autoimmune Diseases
A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice.
Antimycobacterial hsp65 and rheumatoid factor titres in a population of normal twins: evidence of genetic control of rheumatoid factor.
Autoantibodies against chaperonin CCT in human sera with rheumatic autoimmune diseases: comparison with antibodies against other Hsp60 family proteins.
Autoimmunity to HSP60 during diet induced obesity in mice.
Autolytic Mycobacterium leprae Hsp65 fragments may act as biological markers for autoimmune diseases.
Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in pristane induced arthritis susceptible and hsp65 protected DBA/1 mice.
Cellular autoreactivity against heat shock protein 60 in renal transplant patients: peripheral and graft-infiltrating responses.
Cloning and nucleotide sequence comparison of the groE operon of Pseudomonas aeruginosa and Burkholderia cepacia.
Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection.
Heat shock protein 10 (Hsp10) in immune-related diseases: one coin, two sides.
Heat-shock proteins and autoimmunity in humans.
Helicobacter pylori infection in connective tissue disorders is associated with high levels of antibodies to mycobacterial hsp65 but not to human hsp60.
Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives.
Identification of heat shock protein 10 within the equine embryo, endometrium, and maternal peripheral blood mononuclear cells.
Induction of Porphyromonas gingivalis GroEL signaling via binding to Toll-like receptors 2 and 4.
Levels of intra- and extracellular heat shock protein 60 in Kawasaki disease patients treated with intravenous immunoglobulin.
Low levels of heat shock proteins-60 and -65 autoantibodies in Sjögren's syndrome.
M. paratuberculosis Heat Shock Protein 65 and Human Diseases: Bridging Infection and Autoimmunity.
Modulation of pristane-induced arthritis by mycobacterial antigens.
pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity.
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease.
Sequence and structural homologies between M. tuberculosis chaperonin 10 and the MHC class I/II peptide binding cleft.
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.
Susceptibility to pristane-induced arthritis is altered with changes in bowel flora.
What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?
[Induction of mucosal immunity to mycobacterial heat shock protein (hsp) 65 by colonic inoculation of plasmid DNA encoding hsp65]
Bacterial Infections
Hsp90, Hsp60 and sHsp families of heat shock protein genes in channel catfish and their expression after bacterial infections.
Behcet Syndrome
Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease.
The role of heat shock protein 60, vascular endothelial growth factor and antiphospholipid antibodies in Behçet disease.
Bone Diseases
Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease.
Bone Resorption
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.
Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency.
Human chaperonin 60 (Hsp60) stimulates bone resorption: structure/function relationships.
Immunologic response enhances atherosclerosis-type 1 helper T cell (Th1)-to-type 2 helper T cell (Th2) shift and calcified atherosclerosis in Bacillus Calmette-Guerin (BCG)-treated apolipoprotein E-knockout (apo E-/-) mice.
Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops.
Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease.
Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.
Brain Injuries, Traumatic
Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury.
Brain Ischemia
Induction of mitochondrial heat shock protein 60 and 10 mRNAs following transient focal cerebral ischemia in the rat.
Breast Neoplasms
Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer.
Archaeosome: as new drug carrier for delivery of Paclitaxel to breast cancer.
Chaperonin CCT-mediated AIB1 folding promotes the growth of ER?-positive breast cancer cells on hard substrates.
Chaperonin Containing-TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide.
Do heat shock proteins have a role in breast cancer?
High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65.
Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival.
Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ.
Retraction: Chaperonin CCT-Mediated AIB1 Folding Promotes the Growth of ER?-Positive Breast Cancer Cells on Hard Substrates.
Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma.
Bronchitis
Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults.
Buruli Ulcer
Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer.
Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.
Carcinogenesis
60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis.
A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis.
Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin.
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer.
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Gonadal apoptosis during sex reversal of the rice field eel: implications for an evolutionarily conserved role of the molecular chaperone heat shock protein 10.
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.
High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment.
Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous-cell carcinoma.
Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis.
Immunopositivity of heat shock protein 60 as a biomarker of bronchial carcinogenesis.
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer.
Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.
The C-Terminal Disulfide Bonds of Helicobacter pylori GroES Are Critical for IL-8 Secretion via the TLR4-Dependent Pathway in Gastric Epithelial Cells.
Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format.
Carcinoma
Association between hsp60 messenger-RNA levels and Cisplatin resistance in human head and neck-cancer cell-lines.
Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.
Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma.
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery.
Erratum: Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma: Erratum.
High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma.
HSP60 and HSP10 as diagnostic and prognostic tools in the management of exocervical carcinoma.
Identification of candidate antigens for serologic detection of Helicobacter pylori-infected patients with gastric carcinoma.
Immunotherapy of a human papillomavirus type 16 E7-expressing tumor by administration of fusion protein comprised of Mycobacterium bovis BCG Hsp65 and HPV16 E7.
Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma.
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Relationship between expression of HSP60, urease activity, production of vacuolating toxin, and adherence activity of Helicobacter pylori.
Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
Carcinoma, Adenosquamous
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Carcinoma, Embryonal
Subunits of the eukaryotic cytosolic chaperonin CCT do not always behave as components of a uniform hetero-oligomeric particle.
Carcinoma, Endometrioid
Direct analysis of laser capture microdissected endometrial carcinoma and epithelium by matrix-assisted laser desorption/ionization mass spectrometry.
Carcinoma, Hepatocellular
Chaperonin containing TCP1, subunit 8 (CCT8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation.
Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: A Study based on microarray and RNA-sequencing with 4272 cases.
Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma.
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives.
Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro.
Induction of mitochondrial chaperonin, hsp60, by cadmium in human hepatoma cells.
Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells.
Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence.
Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma.
Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma.
Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2.
Promising Urinary Protein Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients.
Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome.
Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.
Carcinoma, Non-Small-Cell Lung
Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.
Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma.
Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer.
Erratum: Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma: Erratum.
Heat shock protein 60 is a disease-associated sialoglycoprotein in human non-small cell lung cancer.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
Cardiomyopathies
Cytokine production and antibodies against heat shock protein 60 in cardiomyopathies of different origins.
Cardiomyopathy, Dilated
Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
The expression of heat shock protein 60 in patients with dilated cardiomyopathy.
Cardiovascular Diseases
Antibodies against heat shock protein 60 derived from Helicobacter pylori: diagnostic implications in cardiovascular disease.
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk.
Autoimmunity, Infectious Immunity, and Atherosclerosis.
Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-?B: Implications for the health effects of air pollution and oxidative stress.
Circulating heat shock protein 60 is associated with early cardiovascular disease.
Comparative analysis of linear antibody epitopes on human and mycobacterial 60-kDa heat shock proteins using samples of healthy blood donors.
Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes.
Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice.
Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story.
Heat Shock Protein 60 Antibodies Are Associated With a Risk Factor for Cardiovascular Disease in Bedridden Elderly Patients.
Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease.
Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors.
Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens.
Carotid Artery Diseases
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis.
Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study.
Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction.
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
The role of (auto-) immunity in atherogenesis.
Cataract
Heat shock protein expression in human conjunctiva.
Chagas Disease
Expression and role of heat-shock protein 65 (HSP65) in macrophages during Trypanosoma cruzi infection: involvement of HSP65 in prevention of apoptosis of macrophages.
Gene characterization and predicted protein structure of the mitochondrial chaperonin HSP10 of Trypanosoma cruzi.
chaperonin atpase deficiency
Disruption of the chaperonin containing TCP-1 function affects protein networks essential for Rod outer segment morphogenesis and survival.
Functional analysis of isolated cpn10 domains and conserved amino acid residues in spinach chloroplast co-chaperonin by site-directed mutagenesis.
Chlamydophila Infections
Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults.
Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk.
Chlamydia heat shock protein 60 decreases expression of eNOS in human and porcine coronary artery endothelial cells.
Chlamydia pneumoniae infection and inflammation in adults with asthma.
Heat shock protein 10 of Chlamydophila pneumoniae induces proinflammatory cytokines through Toll-like receptor (TLR) 2 and TLR4 in human monocytes THP-1.
Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection.
Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma.
[Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link between infection and atherosclerosis]
Cholera
Detection of Vibrio cholerae by real-time nucleic acid sequence-based amplification.
Immune response to an 18-kilodalton outer membrane antigen identifies lipoprotein 20 as a Helicobacter pylori vaccine candidate.
New approaches in the treatment of Adamantiades-Behçet's disease.
Oral Immunization with a Multivalent Epitope-Based Vaccine, Based on NAP, Urease, HSP60, and HpaA, Provides Therapeutic Effect on H. pylori Infection in Mongolian gerbils.
Chronic Periodontitis
Effect of periodontal treatment on the serum antibody levels to heat shock proteins.
T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis.
Ciliopathies
Ancient Origin of Chaperonin Gene Paralogs Involved in Ciliopathies.
Cleft Palate
[Expression of sHsps of normal palate and cleft palate during mouse embryogenesis]
Colitis
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response.
An appraisal of the gut health modulatory effects of a calf faecal-origin probiotic Lactobacillus salivarius CPN60 using Wistar rats with dextran sulfate sodium-induced colitis.
Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice.
Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation.
Invasive Lactococcus lactis producing mycobacterial Hsp65 ameliorates intestinal inflammation in acute TNBS-induced colitis in mice by increasing the levels of the cytokine IL-10 and secretory IgA.
Involvement of luminal bacteria, heat shock protein 60, macrophages and gammadelta T cells in dextran sulfate sodium-induced colitis in rats.
Mycobacterial Hsp65 antigen delivered by invasive Lactococcus lactis reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model.
Colitis, Ulcerative
Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.
Hsp60 and Hsp10 increase in colon mucosa of Crohn's disease and ulcerative colitis.
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
Colonic Neoplasms
Extracellular chaperonin 10 augments apoptotic cell death induced by 5-fluorouracil in human colon cancer cells.
Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
Colorectal Neoplasms
Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer.
Detection and identification of heat shock protein 10 as a biomarker in colorectal cancer by protein profiling.
Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays.
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer.
Inhibition of cytosolic chaperonin CCT?-1 expression depletes proliferation of colorectal carcinoma in vitro.
The proteomics of colorectal cancer: identification of a protein signature associated with prognosis.
Communicable Diseases
Characterization of serum antibody to Actinobacillus actinomycetemcomitans GroEL-like protein in periodontitis patients and healthy subjects.
Recombinant heat shock protein 65 carrying hepatitis B core antigen induces HBcAg-specific CTL response.
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins.
Congenital Abnormalities
GroEL is involved in activation of Escherichia coli RNA polymerase devoid of the omega subunit in vivo.
Contracture
Chaperonin containing T-complex polypeptide subunit eta is a potential marker of joint contracture: an experimental study in the rat.
Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture.
Coronary Artery Disease
Adventitial heat shock protein 60 in human coronary atherosclerosis.
Association of anti-heat shock protein 65 antibodies with development of postoperative atrial fibrillation.
Association of serum soluble heat shock protein 60 with toll-like receptor 4 polymorphism and severity of coronary artery disease.
Chlamydia pneumoniae heat shock protein 60 enhances expression of ERK, TLR-4 and IL-8 in atheromatous plaques of coronary artery disease patients.
Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.
Chronic Infections and Atherosclerosis.
Elevated Anti-Heat Shock Protein 60 Antibody Titer is Related to White Matter Hyperintensities.
Joint effects of antibody to heat shock protein 60, hypertension, and diabetes on risk of coronary heart disease in Chinese.
Prevalence of intimal heat shock protein 60 homologues in unstable angina and correlation with anti-heat shock protein antibody titers.
Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease.
Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection.
[Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link between infection and atherosclerosis]
Coronary Disease
Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction.
Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.
Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a case-control study.
H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease.
Helicobacter pylori heat shock protein 60 and risk of coronary heart disease: a case control study with focus on markers of systemic inflammation and lipids.
Joint effects of antibody to heat shock protein 60, hypertension, and diabetes on risk of coronary heart disease in Chinese.
Low prevalence of antibodies against heat shock protein 10 of Chlamydophila pneumoniae in patients with coronary heart disease.
Vitamin D supplementation and serum heat shock protein 60 levels in patients with coronary heart disease: a randomized clinical trial.
Crohn Disease
Hsp60 and Hsp10 increase in colon mucosa of Crohn's disease and ulcerative colitis.
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
Cystic Fibrosis
Concentration of circulating autoantibodies against HSP 60 is lowered through diving when compared to non-diving rats.
Development of real-time PCR assays for detection of the Streptococcus milleri group from cystic fibrosis clinical specimens by targeting the cpn60 and 16S rRNA genes.
Intra- and interpatient variability of the hsp65 and 16S-23S intergenic gene region in Mycobacterium abscessus strains from patients with cystic fibrosis.
Cysts
Levels of heat shock protein transcripts in normal follicles and ovarian follicular cysts.
Overexpression and extra-mitochondrial localization of the chaperonin Hsp60 in ameloblastoma.
Demyelinating Diseases
Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.
Dengue
DNA Vaccines against Dengue Virus Type 2 Based on Truncate Envelope Protein or Its Domain III.
Dermatitis Herpetiformis
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Dermatitis, Atopic
Expression of 27 KD, 65 KD and 72/73 KD heat shock protein in atopic dermatitis: comparison with those in normal skin and contact dermatitis.
Dermatitis, Contact
Expression of 27 KD, 65 KD and 72/73 KD heat shock protein in atopic dermatitis: comparison with those in normal skin and contact dermatitis.
Dermatitis, Seborrheic
Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis.
Diabetes Mellitus
A rationally designed peptide IA-2-P2 against type 1 diabetes in streptozotocin-induced diabetic mice.
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis : clinical significance determined in a follow-up study.
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis.
Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
Fusion protein His-Hsp65-6IA2P2 prevents type 1 diabetes through nasal immunization in NOD Mice.
Mycobacterial Hsp65 potentially cross-reacts with autoantibodies of diabetes sera and also induces (in vitro) cytokine responses relevant to diabetes mellitus.
Small Heat Shock Proteins HSP10 and HSP27 in the Left Ventricular Myocardium in Rats with Arterial Hypertension and Insulin-Dependent Diabetes Mellitus.
What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?
Diabetes Mellitus, Type 1
A rationally designed peptide IA-2-P2 against type 1 diabetes in streptozotocin-induced diabetic mice.
Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus.
Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia.
Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes.
Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform.
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus.
Detection of heat shock protein in patients with insulin-dependent diabetes mellitus.
DiaPep277 (DeveloGen).
Enhanced immunogenicity of peptide P277 by heat shock protein HSP65 vector carrying tandem repeats of P277 to prevent type 1 diabetes in NOD mice.
Fusion protein His-Hsp65-6IA2P2 prevents type 1 diabetes through nasal immunization in NOD Mice.
Heat shock protein 60 elicits abnormal response in macrophages of diabetes-prone non-obese diabetic mice.
Heat shock protein studies in type 1 and type 2 diabetes and human islet cell culture.
HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration.
Immunomodulation with heat shock protein DiaPep277 to preserve beta cell function in type 1 diabetes - an update.
Neonatal oral administration of DiaPep277, combined with hydrolysed casein diet, protects against Type 1 diabetes in BB-DP rats. An experimental study.
Picornavirus proteins share antigenic determinants with heat shock proteins 60/65.
Prevention of diabetes in non-obese diabetic mice by a single immunization with Mycobacterium leprae.
Recognition of heat shock protein 60 epitopes in children with type 1 diabetes.
Small Heat Shock Proteins HSP10 and HSP27 in the Left Ventricular Myocardium in Rats with Arterial Hypertension and Insulin-Dependent Diabetes Mellitus.
Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277.
Vaccine therapies for the prevention of type 1 diabetes mellitus.
What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?
Diabetes Mellitus, Type 2
Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity.
Is heat shock protein 60 associated with type 2 diabetes mellitus?
Diabetic Cardiomyopathies
Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.
Diabetic Nephropathies
Chaperonin-containing t-complex protein-1 subunit ? as a possible biomarker for the phase of glomerular hyperfiltration of diabetic nephropathy.
Digestive System Neoplasms
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
Down Syndrome
Deficiency of chaperonin 60 in Down's syndrome.
Dyslipidemias
Antibodies to human heat shock protein 60, hypertension and dyslipidemia. A study of joint effects on coronary risk.
Elephantiasis, Filarial
Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis.
Encephalitis
T and B cell responses to mycobacterial 65-kDa heat-shock protein in sheep infected with maedi visna virus.
Encephalitis, Japanese
Gateways to clinical trials.
Encephalomyelitis
Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS.
Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system.
Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells.
[Target antigens in neuroimmunological diseases]
Encephalomyelitis, Acute Disseminated
[Target antigens in neuroimmunological diseases]
Encephalomyelitis, Autoimmune, Experimental
Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS.
Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system.
Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells.
Endometrial Neoplasms
A strategy for high-resolution protein identification in surface-enhanced laser desorption/ionization mass spectrometry: calgranulin A and chaperonin 10 as protein markers for endometrial carcinoma.
Infrared multiphoton dissociation in quadrupole time-of-flight mass spectrometry: top-down characterization of proteins.
Endotoxemia
Long-lasting effect of infant rats endotoxemia on heat shock protein 60 in the pancreatic acinar cells: involvement of toll-like receptor 4.
Enterovirus Infections
Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans.
Eosinophilia
Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation.
Erythema Nodosum
Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients.
Extensively Drug-Resistant Tuberculosis
Novel therapeutic vaccines [(HSP65 + IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy.
Fatigue Syndrome, Chronic
Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.
Fibrosarcoma
Mutational analysis of human tumor necrosis factor-alpha.
Foot-and-Mouth Disease
Chaperonin 10 of Mycobacterium tuberculosis induces a protective immune response to foot-and-mouth disease virus.
Friedreich Ataxia
Probing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform.
Furunculosis
Mycobacterium bolletii/Mycobacterium massiliense furunculosis associated with pedicure footbaths: a report of 3 cases.
Gastritis
Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer.
Effect of bacterial flora on postimmunization gastritis following oral vaccination of mice with Helicobacter pylori heat shock protein 60.
Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori.
Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia.
Gastroschisis
Maternal Antibodies to Chlamydia trachomatis and Risk of Gastroschisis.
Genetic Diseases, Inborn
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Gingivitis
Salivary anti-hsp65 antibodies as a diagnostic marker for gingivitis and a possible link to atherosclerosis.
Glaucoma
Enhanced characterization of serum autoantibody reactivity following HSP 60 immunization in a rat model of experimental autoimmune glaucoma.
Modulation of the immune system for the treatment of glaucoma.
Serum Biomarkers for the Diagnosis of Glaucoma.
Glaucoma, Open-Angle
Serum Biomarkers for the Diagnosis of Glaucoma.
Glioblastoma
Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance.
Glioma
Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas.
Effects of alcohol on gene expression in neural cells.
Long non-coding RNA NEAT1 promotes human glioma tumor progression via miR-152-3p/CCT6A pathway.
Glomerulonephritis
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Graft vs Host Disease
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production.
Granuloma
Comparison of the Moonlighting Actions of the Two Highly Homologous Chaperonin 60 Proteins of Mycobacterium tuberculosis.
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Molecular characterization of a novel fastidious mycobacterium causing lepromatous lesions of the skin, subcutis, cornea, and conjunctiva of cats living in Victoria, Australia.
Graves Disease
Heat shock protein 60 mRNA is not increased in Graves' disease thyroid tissue.
High expression of heat shock protein 60 in follicular cells of Hashimoto's thyroiditis.
Guillain-Barre Syndrome
[Target antigens in neuroimmunological diseases]
Heart Arrest
10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat.
Heart Diseases
Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease.
Helicobacter pylori-induced immunological responses in patients with duodenal ulcer and in patients with cardiomyopathies.
Heart Failure
Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure.
Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Serum Heat Shock Protein 60 in Acute Heart Failure: A New Biomarker?
Hepatitis
Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.
Hepatitis B
A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle.
Antisense oligodeoxynucleotides targeted against molecular chaperonin Hsp60 block human hepatitis B virus replication.
Gateways to clinical trials.
Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes.
Human hepatitis B virus polymerase interacts with the molecular chaperonin Hsp60.
Immunization with a peptide corresponding to chlamydial heat shock protein 60 increases the humoral immune response in C3H mice to a peptide representing variable domain 4 of the major outer membrane protein of Chlamydia trachomatis.
Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis.
Hepatitis C
Promising Urinary Protein Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients.
Hereditary Sensory and Autonomic Neuropathies
Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.
Herpes Simplex
Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angioplasty.
Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease.
Infections as a stimulus for coronary occlusion, obstruction, or acute coronary syndromes.
Pathogen burden in degenerative aortic valves is associated with inflammatory and immune reactions.
Herpes Zoster
Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition.
Histoplasmosis
Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis.
Huntington Disease
The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington's disease.
TRiC enhances retrograde axonal transport by modulating tau phosphorylation.
Hyperglycemia
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.
Hyperlipidemias
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Immune-mediated mechanisms of endothelial damage in atherosclerosis.
Hypersensitivity
Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis.
Identification of Chlamydia trachomatis antigens by use of murine T-cell lines.
Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.
Ribosomal protein L7 included in tuberculin purified protein derivative (PPD) is a major heat-resistant protein inducing strong delayed-type hypersensitivity.
Hypersensitivity, Delayed
Modulation of expression of delayed hypersensitivity by mycobacterial antigen 85 fibronectin-binding proteins.
Hypertension
Antibodies to human heat shock protein 60, hypertension and dyslipidemia. A study of joint effects on coronary risk.
Association of serum antibodies to heat-shock protein 65 with borderline hypertension.
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis : clinical significance determined in a follow-up study.
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis.
Cardiovascular risk factors and atherosclerosis in young women: atherosclerosis risk factors in female youngsters (ARFY study).
Joint effects of antibody to heat shock protein 60, hypertension, and diabetes on risk of coronary heart disease in Chinese.
Small Heat Shock Proteins HSP10 and HSP27 in the Left Ventricular Myocardium in Rats with Arterial Hypertension and Insulin-Dependent Diabetes Mellitus.
Hypogonadism
Mutation profile of BBS genes in patients with Bardet-Biedl syndrome: an Italian study.
Infarction, Middle Cerebral Artery
NO-induced downregulation of HSP10 and HSP60 expression in the postischemic brain.
Infections
A simple and rapid method for the purification of GroEL, an Escherichia coli homolog of the heat shock protein 60 family of molecular chaperonins.
A subunit vaccine based on biodegradable microspheres carrying rHsp65 protein and KLK protects BALB/c mice against tuberculosis infection.
A virulence factor of Helicobacter pylori: role of heat shock protein in mucosal inflammation after H. pylori infection.
Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.
Adjunctive immunotherapy of mycobacterial infections.
Aerococcus viridans expression of Cpn60 is associated with virulence during infection of the American lobster, Homarus americanus Milne Edwards.
Analysis of heat shock protein 60 encoding genes of mycoplasmas and investigations concerning their role in immunity and infection.
Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults.
Antibodies specific for heat shock proteins in human and murine malaria.
Antigen specificity in experimental bovine tuberculosis.
Archaeosome adjuvants: Immunological capabilities and mechanism(s) of action.
Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes.
Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10.
Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk.
Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.
Bordetella pertussis Proteins Dominating the MHC Class II-Presented Epitope Repertoire in human monocyte derived dendritic cells.
CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major.
CD4+ T cells are required for HSP65 expression in host macrophages and for protection of mice infected with Plasmodium yoelii.
Cell-mediated immune responses and protective efficacy against infection with Mycobacterium tuberculosis induced by Hsp65 and hIL-2 fusion protein in mice.
Cellular chaperonin CCT? contributes to rabies virus replication during infection.
Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3.
Chaperonin 10 of Mycobacterium tuberculosis induces a protective immune response to foot-and-mouth disease virus.
Chlamydia heat shock protein 60 decreases expression of eNOS in human and porcine coronary artery endothelial cells.
Chlamydia pneumoniae infection and inflammation in adults with asthma.
Chlamydia trachomatis Infection Is Related to Poor Semen Quality in Young Prostatitis Patients.
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway.
Chlamydial serology: comparative diagnostic value of immunoblotting, microimmunofluorescence test, and immunoassays using different recombinant proteins as antigens.
Cloning and kinetics of expression of Brucella abortus heat shock proteins by baculovirus recombinants.
Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.
Concentration of circulating autoantibodies against HSP 60 is lowered through diving when compared to non-diving rats.
Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection.
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor.
Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy.
Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue.
Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins.
Disseminated infection due to Mycobacterium avium subsp. avium in an Asian elephant (Elephas maximus).
Diversity of pulsed-field gel electrophoresis patterns of Mycobacterium abscessus type 2 clinical isolates.
DNA Vaccines against Dengue Virus Type 2 Based on Truncate Envelope Protein or Its Domain III.
Does serologic evidence of remote Chlamydia trachomatis infection and its heat shock protein (CHSP 60) affect in vitro fertilization-embryo transfer outcome?
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Early antibody response and clinical outcome in experimental canine leishmaniasis.
Effect of bacterial flora on postimmunization gastritis following oral vaccination of mice with Helicobacter pylori heat shock protein 60.
Effects of turnip crinkle virus infection on the structure and function of mitochondria and expression of stress proteins in turnips
Efficacy of DNA-hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo.
Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs.
Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans.
Evaluation of hsp65 nested PCR-restriction analysis (PRA) for diagnosing tuberculosis in a high burden country.
Expression and role of heat-shock protein 65 (HSP65) in macrophages during Trypanosoma cruzi infection: involvement of HSP65 in prevention of apoptosis of macrophages.
First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing.
First report on isolation and molecular characterization of clinical Mycobacterium setense isolates in Asia.
Further characteristics of Actinomyces weissii, a novel species isolated from the oral cavity of dogs.
Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii.
Granulomatous pneumonia in a captive freshwater crocodile (Crocodylus johnstoni) caused by Mycobacterium szulgai.
H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease.
Heat shock protein 10 regulated apoptosis of mouse ovarian granulosa cells.
Heat shock protein 60 (HSP60) immunoreactivity in gastric epithelium associated with Helicobacter pylori infection: a pitfall in immunohistochemically interpreting HSP60-mediated autoimmune responses.
Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection.
Heat shock protein 60 specific T-cell response in chlamydial infections.
Heat shock protein 65 induced by gammadelta T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii.
Heat shock protein profiles on the protein and gene expression levels in olive flounder kidney infected with Streptococcus parauberis.
Helicobacter pylori infection in connective tissue disorders is associated with high levels of antibodies to mycobacterial hsp65 but not to human hsp60.
Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma.
Human antibody responses to a Chlamydia-secreted protease factor.
Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori.
Identification of autoantibodies with the corresponding antigen for repetitive coxsackievirus infection-induced cardiomyopathy.
Identification of Cutaneous Mycobacterium massiliense Infections Associated with Repeated Surgical Procedures.
Identification of nontuberculous mycobacterial infection by IS6110 and hsp65 gene analysis on lung tissues.
Immunoglobulin A and CD8 T-Cell Mucosal Immune Defenses Protect Against Intranasal Infection with Chlamydia pneumoniae.
Immunohistochemical analysis of TNF-alpha and HSP-60 in women with tubal factor infertility associated with Chlamydia trachomatis.
Immunopathogenesis of Behçet's disease.
Increased expression of HDJ-2 (heat shock protein 40) and heat shock protein 70 in biopsy specimens of transplanted human lungs.
Infectious agents and atherosclerosis: current perspectives and unsolved issues.
Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study.
Interaction mechanism of Mycobacterium tuberculosis GroEL2 protein with macrophage Lectin-like, oxidized low-density lipoprotein receptor-1: An integrated computational and experimental study.
Interaction of heat shock protein 60 (HSP60) with microRNA in Chinese mitten crab during Spiroplasma eriocheiris infection.
Investigation of Immune Biomarkers Using Subcutaneous Model of M. tuberculosis Infection in BALB/c Mice: A Preliminary Report.
Isolation and characterization of an immunogenic fragment of heat shock protein 60 from Trichophyton mentagrophytes.
Low-Dose Aspirin May Prevent Trophoblast Dysfunction in Women With Chlamydia Pneumoniae Infection.
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.
Mechanisms of HSP65 expression induced by gamma delta T cells in murine Toxoplasma gondii infection.
miR-382-5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon.
Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts.
Molecular diagnostic assays based on cpn60 UT sequences reveal the geographic distribution of subgroup 16SrXIII-(A/I)I phytoplasma in Mexico.
Molecular Typing of Mycobacterium intracellulare Using Pulsed-Field Gel Electrophoresis, Variable-Number Tandem-Repeat Analysis, Mycobacteria Interspersed Repetitive-Unit-Variable-Number Tandem Repeat Typing, and Multilocus Sequence Typing: Molecular Characterization and Comparison of Each Typing Methods.
Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1-like cytokine secretion profile: heterogeneity in cytotoxic activity and cytokine secretion levels.
Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages.
Mycobacterial Cpn10 promotes recognition of the mammalian homologue by a mycobacterium-specific antiserum.
Mycobacterium hsp65 DNA entrapped into TDM-loaded PLGA microspheres induces protection in mice against Leishmania (Leishmania) major infection.
Mycobacterium paragordonae sp. nov., a novel slowly growing scoto-chromogenic species closely related to Mycobacterium gordonae.
Mycobacterium peregrinum infection in farmed European tench (Tinca tinca L.).
Mycobacterium pseudoshottsii Isolated from 24 Farmed Fishes in Western Japan.
Mycobacterium seoulense sp. nov., a slowly growing scotochromogenic species.
Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway.
Nocardia cyriacigeorgica, an emerging pathogen in the United States.
Nontuberculous mycobacterial cutaneous infection confirmed by biochemical tests, polymerase chain reaction-restriction fragment length polymorphism analysis and sequencing of hsp65 gene.
Oral Tolerance Induced by Heat Shock Protein 65-Producing Lactococcus lactis Mitigates Inflammation in Leishmania braziliensis Infection.
Passive immunization with a monoclonal IgM antibody specific for Strongyloides ratti HSP60 protects mice against challenge infection.
Patterns of expression of viral and cytokine gene transcripts during mouse polyoma virus infection.
PCR-restriction enzyme analysis of a bone marrow isolate from a human immunodeficiency virus-positive patient discloses polyclonal infection with two Mycobacterium avium strains.
Peripheral blood mononuclear cell responses to heat shock proteins in patients undergoing stem cell transplantation.
Phylogenetic analysis of Mycobacterium massiliense strains having recombinant rpoB gene laterally transferred from Mycobacterium abscessus.
Pivotal pathogenic and biomarker role of Chlamydia Pneumoniae in neurovascular diseases.
Plasma membrane expression of heat shock protein 60 in vivo in response to infection.
Porphyromonas gingivalis HSP60 peptides have distinct roles in the development of atherosclerosis.
Prevention of adjuvant arthritis in Lewis rats by neonatal bacille Calmette-Guerin (BCG) infection.
Prospective investigation of polyomavirus infection and the risk of adult glioma.
Protective DNA immunization against Chlamydia pneumoniae.
Proteomic analysis of differentially expressed Chlamydia pneumoniae genes during persistent infection of HEp-2 cells.
Rapid identification of cutaneous infections by nontubercular mycobacteria by polymerase chain reaction-restriction analysis length polymorphism of the hsp65 gene.
Recombinant GroES in combination with CpG oligodeoxynucleotides protects mice against Mycobacterium avium infection.
Role of innate immune cells in protection against Toxoplasma gondii at inflamed site.
Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages.
Serological association between Chlamydia pneumoniae infection and age-related macular degeneration.
Seropositivity for the human heat shock protein (Hsp)60 accompanying seropositivity for Chlamydia trachomatis is less prevalent among tubal ectopic pregnancy cases than individuals with normal reproductive history.
Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis.
SV40 Polyomavirus Activates the Ras-MAPK Signaling Pathway for Vacuolization, Cell Death, and Virus Release.
T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts.
Targeted capture of pathogenic bacteria using a mammalian cell receptor coupled with dielectrophoresis on a biochip.
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.
The association of C (-260)-->T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients.
The chaperonin CCT8 facilitates spread of tobamovirus infection.
The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.
The N terminus of the head protein of T4 bacteriophage directs proteins to the GroEL chaperonin.
The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins.
The Viability and Protein Expression of Beijing/W Lineage Mycobacterium tuberculosis Circulating in Xinjiang, China.
Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 (HSP60) but not human HSP60.
Ubiquitin-fusion degradation pathway: a new strategy for inducing CD8 cells specific for mycobacterial HSP65.
Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10.
Usefulness of Housekeeping Genes for the Diagnosis of Helicobacter pylori Infection, Strain Discrimination and Detection of Multiple Infection.
Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection.
Vaccination with Strongyloides ratti heat shock protein 60 increases susceptibility to challenge infection by induction of Th1 response.
[BCG vaccination to Mycobacterium leprae infection in mice]
[Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link between infection and atherosclerosis]
[Preparation oral liposome-encapsulated recombinant Helicobacter pylori heat shock protein 60 vaccine for prevention of Hp infection]
[Studies on immunogenicity and immunoprotection induced by heat shock protein 60 kDa of Schistosoma japonicum in mice].
Infertility
A PROSPECTIVE STUDY TO ANALYZE THE SPECIFICITY OF CHLAMYDIAL HEAT SHOCK PROTEIN (CHSP60) ANTIBODIES TO DIAGNOSE TUBAL INFERTILITY.
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60.
Antibodies to Chlamydia trachomatis heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31.
Association of uterine and salpingeal fibrosis with chlamydial hsp60 and hsp10 antigen-specific antibodies in Chlamydia-infected koalas.
Characterization of humoral immune responses to chlamydial HSP60, CPAF, and CT795 in inflammatory and severe trachoma.
Chlamydial heat shock protein 60--specific T cells in inflamed salpingeal tissue.
Chlamydial heat shock proteins and disease pathology: new paradigms for old problems?
Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility.
Human leukocyte antigen class II DQ alleles associated with Chlamydia trachomatis tubal infertility.
Immunohistochemical analysis of TNF-alpha and HSP-60 in women with tubal factor infertility associated with Chlamydia trachomatis.
Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease.
The presence of serum antibody to the chlamydial heat shock protein (CHSP60) as a diagnostic test for tubal factor infertility.
Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 (HSP60) but not human HSP60.
Infertility, Female
[Research on endometrial heat shock protein 60 KDA in the study of female infertility]
Inflammatory Bowel Diseases
Hsp60 and Hsp10 increase in colon mucosa of Crohn's disease and ulcerative colitis.
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
[Induction of mucosal immunity to mycobacterial heat shock protein (hsp) 65 by colonic inoculation of plasmid DNA encoding hsp65]
Influenza, Human
Archaeal glycolipid adjuvanted vaccines induce strong influenza-specific immune responses through direct immunization in young and aged mice or through passive maternal immunization.
Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.
Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.
Gateways to clinical trials.
hsp65 mRNA+ macrophages and gamma delta T cells in influenza virus-infected mice depleted of the CD4+ and CD8+ lymphocyte subsets.
Priming of CD8+ CTL effector cells in mice by immunization with a stress protein-influenza virus nucleoprotein fusion molecule.
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60.
Selective response of gamma delta T-cell hybridomas to orthomyxovirus-infected cells.
Insulin Resistance
Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus.
Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance.
Insulinoma
A novel multi-epitope vaccine based on Dipeptidyl Peptidase 4 prevents streptozotocin-induced diabetes by producing anti-DPP4 antibody and immunomodulatory effect in C57BL/6J mice.
A Novel Multi-Epitope Vaccine Based on Urate Transporter 1 Alleviates Streptozotocin-Induced Diabetes by Producing Anti-URAT1 Antibody and an Immunomodulatory Effect in C57BL/6J Mice.
Construction of a novel vaccine by conjugating a B-cell epitope of DPP4 to peptide IA2(5)-P2-1 to significantly control type 1 diabetes in NOD mice.
Intestinal Volvulus
Characterization of the heat-shock protein 60 chaperonin from Onchocerca volvulus.
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria.
Obligatory symbiotic Wolbachia endobacteria are absent from Loa loa.
The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia.
Iron Deficiencies
Cardiac nuclear encoded cytochrome c oxidase subunits are decreased with copper restriction but not iron restriction: gene expression, protein synthesis and heat shock protein aspects.
Isaacs Syndrome
[Target antigens in neuroimmunological diseases]
Joint Diseases
Rheumatoid factor, anti-heat shock protein (65 kDa) antibodies and anti-nuclear antibodies in equine joint diseases.
Keratitis
An outbreak of keratitis caused by Mycobacterium immunogenum.
Keratoconjunctivitis
Heat shock protein expression in human conjunctiva.
Lambert-Eaton Myasthenic Syndrome
[Target antigens in neuroimmunological diseases]
Legionnaires' Disease
The Legionella pneumophila Chaperonin - An Unusual Multifunctional Protein in Unusual Locations.
Leishmaniasis
DNAhsp65 vaccination induces protection in mice against Paracoccidioides brasiliensis infection.
Mycobacterium hsp65 DNA entrapped into TDM-loaded PLGA microspheres induces protection in mice against Leishmania (Leishmania) major infection.
Leishmaniasis, Visceral
Expression and subcellular localization of cpn60 protein family members in Leishmania donovani.
Immunological consequences of stress-related proteins - cytosolic tryparedoxin peroxidase and chaperonin TCP20 - identified in splenic amastigotes of Leishmania donovani as Th1 stimulatory, in experimental visceral leishmaniasis.
Leprosy
CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction.
Conserved TcR beta chain usage for a single MHC class II-restricted heat shock protein peptide.
Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue.
HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells.
Identification of novel hsp65 RFLPs for Mycobacterium leprae.
Immune profiling of leprosy and tuberculosis patients to 15-mer peptides of Mycobacterium leprae and M. tuberculosis GroES in a BCG vaccinated area: implications for development of vaccine and diagnostic reagents.
Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD.
Interleukin-12 amplifies the M. leprae hsp65-cytotoxic response in the presence of tumour necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect.
Lysis of autologous macrophages pulsed with hsp10 from Mycobacterium leprae is associated to the absence of bacilli in leprosy.
Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES.
Report of 2 indigenous cases of leprosy from a European country: use of polymerase chain reaction-restriction fragment length polymorphism analysis of hsp65 gene for identification of Mycobacterium leprae directly from a clinical sample.
T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts.
The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis.
Leprosy, Lepromatous
Definition of a human suppressor T-cell epitope.
Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES.
Leprosy, Tuberculoid
Clonal dominance and selection for similar complementarity determining region 3 motifs among T lymphocytes responding to the HLA-DR3-associated Mycobacterium leprae heat shock protein 65-kd peptide 3-13.
Conserved TcR beta chain usage for a single MHC class II-restricted heat shock protein peptide.
Leukemia, Erythroblastic, Acute
Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3.
Leukemia, Myeloid, Acute
Overexpression of heat shock protein 60 and the survival of blast in acute myeloid leukemia after induction therapy.
Lichen Planus, Oral
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Limbic Encephalitis
[Target antigens in neuroimmunological diseases]
Liver Cirrhosis
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Liver Neoplasms
Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
long-chain acyl-coa dehydrogenase deficiency
Fasting induces prominent proteomic changes in liver in very long chain Acyl-CoA dehydrogenase deficient mice.
Lung Diseases
Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins.
Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice.
Short communication: subtyping of Mycobacterium kansasii by PCR-restriction enzyme analysis of the hsp65 gene.
Lung Neoplasms
Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer.
Heat shock protein 60 is a disease-associated sialoglycoprotein in human non-small cell lung cancer.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics.
Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer.
Lupus Erythematosus, Systemic
A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice.
Administration of M. leprae Hsp65 interferes with the murine lupus progression.
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Do heat-shock proteins (Hsps)65-reactive lymphocytes in rheumatoid arthritis, Hashimoto's thyroiditis & systemic lupus erythematosus implicate Hsp65 in autoimmunity?
Lupus Nephritis
Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice.
Lyme Disease
H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme disease.
Lymphadenitis
A mutation in the 65,000 Dalton heat shock protein gene, commonly used for molecular identification of non-tuberculous mycobacteria, leads to the misidentification of Mycobacterium malmoense as Mycobacterium marinum.
First report of cervicofacial lymphadenitis due to Mycobacterium haemophilum in an immunocompromised adult patient.
Lymphatic Metastasis
Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma.
High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
Lymphoma
Antibodies to human gastric epithelial cells and heat shock protein 60 in Helicobacter pylori positive mucosa associated lymphoid tissue lymphoma.
Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT).
Immunoglobulin G1 antibody response to Helicobacter pylori heat shock protein 60 is closely associated with low-grade gastric mucosa-associated lymphoid tissue lymphoma.
Lymphoma, B-Cell
Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT).
Lymphoma, B-Cell, Marginal Zone
Antibodies to human gastric epithelial cells and heat shock protein 60 in Helicobacter pylori positive mucosa associated lymphoid tissue lymphoma.
Immunoglobulin G1 antibody response to Helicobacter pylori heat shock protein 60 is closely associated with low-grade gastric mucosa-associated lymphoid tissue lymphoma.
[Gastric mucosal immunity induced by H. pylori infection]
Lymphoma, Non-Hodgkin
Mycobacterium szulgai identification by hsp65 gene sequencing in an HIV-positive patient with non-Hodgkin's lymphoma.
The role of the Chaperonin containing t-complex polypeptide 1, subunit 8 (CCT8) in B-cell non-Hodgkin's lymphoma.
Malaria
Antibodies specific for heat shock proteins in human and murine malaria.
Gateways to clinical trials.
Isolation and characterization of a chaperonin-60 gene of the human malaria parasite Plasmodium falciparum.
Mania
Elevated heat shock proteins in bipolar disorder patients with hypothalamic pituitary adrenal axis dysfunction.
Mastitis
Use of primers based on the heat shock protein genes hsp70, hsp40, and hsp10, for the detection of bovine mastitis pathogens Streptococcus agalactiae, Streptococcus uberis and Streptococcus bovis.
Melanoma
Administration of heat shock protein 65 inhibits murine melanoma growth in vivo.
Archaeosome adjuvant overcomes tolerance to tumor-associated melanoma antigens inducing protective CD8 T cell responses.
Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 186-193.
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.
Reduced tumorigenicity of B16-F10 mouse melanoma cells transfected with mycobacterial antigen 85A.
Simplified Admix Archaeal Glycolipid Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Enhances Protection from Murine Melanoma.
Meningitis
Gateways to clinical trials.
Mesothelioma
Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models.
Miller Fisher Syndrome
[Target antigens in neuroimmunological diseases]
Mitochondrial Diseases
A fatal, systemic mitochondrial disease with decreased mitochondrial enzyme activities, abnormal ultrastructure of the mitochondria and deficiency of heat shock protein 60.
Chaperonin 60 and mitochondrial disease in Dictyostelium.
Mitochondrial Encephalomyopathies
Decreased synthesis and inefficient mitochondrial import of hsp60 in a patient with a mitochondrial encephalomyopathy.
Mitochondrial Myopathies
Morphology of the mitochondria in heat shock protein 60 deficient fibroblasts from mitochondrial myopathy patients. Effects of stress conditions.
Motor Neuron Disease
Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis.
Prevalence of anti-heat shock protein antibodies in cerebrospinal fluids of patients with Guillain-Barré syndrome.
Mucocutaneous Lymph Node Syndrome
Levels of intra- and extracellular heat shock protein 60 in Kawasaki disease patients treated with intravenous immunoglobulin.
Presence in Kawasaki disease of antibodies to mycobacterial heat-shock protein HSP65 and autoantibodies to epitopes of human HSP65 cognate antigen.
Multiple Myeloma
Circular RNA circ-CCT3 promotes bortezomib resistance in multiple myeloma via modulating miR-223-3p/BRD4 axis.
Multiple Sclerosis
"2-6-11" motif in heat shock protein 60 and central nervous system antigens: a preliminary study in multiple sclerosis patients.
Multiple sclerosis: a protective or a pathogenic role for heat shock protein 60 in the central nervous system?
Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis.
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?
XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator.
[Target antigens in neuroimmunological diseases]
Muscular Diseases
Morphology of the mitochondria in heat shock protein 60 deficient fibroblasts from mitochondrial myopathy patients. Effects of stress conditions.
Myasthenia Gravis
[Target antigens in neuroimmunological diseases]
Mycobacterium Infections
First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing.
Myocardial Infarction
Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction.
Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease.
Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response.
Myocardial Ischemia
Heat shock proteins in myocardial stress.
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.
Nasopharyngeal Carcinoma
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Neoplasm Metastasis
Administration of heat shock protein 65 inhibits murine melanoma growth in vivo.
CCT6A suppresses SMAD2 and promotes prometastatic TGF-? signaling.
Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma.
Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3?-?-Catenin and XIAP-Survivin Pathways.
High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma.
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
Neoplasms
60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis.
A CpG oligodeoxynucleotide potentiates the anti-tumor effect of HSP65-Her2 fusion protein against Her2 positive B16 melanoma in mice.
A strategy for high-resolution protein identification in surface-enhanced laser desorption/ionization mass spectrometry: calgranulin A and chaperonin 10 as protein markers for endometrial carcinoma.
A study of early pregnancy factor activity in the sera of women with trophoblastic tumor.
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
Administration of heat shock protein 65 inhibits murine melanoma growth in vivo.
An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma.
Archaeosome adjuvant overcomes tolerance to tumor-associated melanoma antigens inducing protective CD8 T cell responses.
Archaeosome adjuvants: Immunological capabilities and mechanism(s) of action.
Archaeosomes as self-adjuvanting delivery systems for cancer vaccines.
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures.
Blocking TLR2 activity attenuates pulmonary metastases of tumor.
Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models.
CCT6A, a novel prognostic biomarker for Ewing sarcoma.
Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer.
Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3?-?-Catenin and XIAP-Survivin Pathways.
Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer.
Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65.
Chlamydia trachomatis, Chlamydial Heat Shock Protein 60 and Anti-Chlamydial Antibodies in Women with Epithelial Ovarian Tumors.
Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression.
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer.
Curcumin Affects HSP60 Folding Activity and Levels in Neuroblastoma Cells.
Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis.
Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays.
Differential subcellular sequestration of proapoptotic and antiapoptotic proteins and colocalization of Bcl-x(L) with the germ plasm, in Xenopus laevis oocytes.
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
DNA vaccine encoding heat shock protein 60 co-linked to HPV16 E6 and E7 tumor antigens generates more potent immunotherapeutic effects than respective E6 or E7 tumor antigens.
Do heat shock proteins have a role in breast cancer?
Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.
Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment.
Expression and role of heat-shock protein 65 (HSP65) in macrophages during Trypanosoma cruzi infection: involvement of HSP65 in prevention of apoptosis of macrophages.
Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone.
Gene expression profiling of adrenal cortical tumors by cDNA macroarray analysis. Results of a preliminary study.
GroEL/ES mediated the in vivo recovery of TRAIL inclusion bodies in Escherichia coli.
GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.
Heat shock fusion protein induces both specific and nonspecific anti-tumor immunity.
Heat shock protein 10 (Hsp10) in immune-related diseases: one coin, two sides.
Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production.
Heat shock protein 10 of Chlamydophila pneumoniae induces proinflammatory cytokines through Toll-like receptor (TLR) 2 and TLR4 in human monocytes THP-1.
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells.
Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma.
Helicobacter pylori-derived Heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway.
Histological effect and protein expression in subthreshold transpupillary thermotherapy in rabbit eyes.
HSP-10 in ovarian cancer: expression and suppression of T-cell signaling.
Hsp10: anatomic distribution, functions, and involvement in human disease.
Hsp60 and Hsp10 as Antitumor Molecular Agents.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response.
Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma.
HSP60 participates in the anti-glioma effects of curcumin.
HSP60 Takes a Hit: Inhibition of Mitochondrial Protein Folding.
HSP60-knockdown suppresses proliferation in colorectal cancer cells via activating the adenine/AMPK/mTOR signaling pathway.
HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer.
Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment.
Human gamma delta T cells recognize heat shock protein-60 on oral tumor cells.
Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives.
Identification of elicitor-responsive proteins in rice leaves by a proteomic approach.
Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins.
Immune mechanism of the antitumor effects generated by bortezomib.
Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model.
Immunoelectron microscopy provides evidence for the presence of mitochondrial heat shock 10-kDa protein (chaperonin 10) in red blood cells and a variety of secretory granules.
Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas.
Immunohistochemical analysis of TNF-alpha and HSP-60 in women with tubal factor infertility associated with Chlamydia trachomatis.
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
Immunomodulating activity of mycobacterial heat shock protein 65 in tumor cells.
Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7.
Immunotherapy of a human papillomavirus type 16 E7-expressing tumor by administration of fusion protein comprised of Mycobacterium bovis BCG Hsp65 and HPV16 E7.
Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65.
Indolyl-chalcone derivatives induce hepatocellular carcinoma cells apoptosis through oxidative stress related mitochondrial pathway in vitro and in vivo.
Induction of antigen-specific CD4+ HLA-DR-restricted cytotoxic T lymphocytes as well as nonspecific nonrestricted killer cells by the recombinant mycobacterial 65-kDa heat-shock protein.
Induction of CD4-independent E7-specific CD8+ memory response by heat shock fusion protein.
Induction of human hsp60 expression in monocytic cell lines.
Inhibition effects on liver tumors of BALB/c mice bearing H22 cells by immunization with a recombinant immunogen of GnRH linked to heat shock protein 65.
Inhibition of cytosolic chaperonin CCT?-1 expression depletes proliferation of colorectal carcinoma in vitro.
Interaction of the CD43 Sialomucin with the Mycobacterium tuberculosis Cpn60.2 Chaperonin Leads to Tumor Necrosis Factor Alpha Production.
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis.
Low-Dose Aspirin May Prevent Trophoblast Dysfunction in Women With Chlamydia Pneumoniae Infection.
Metabolic markers and HSP60 in chemonaive serous solid ovarian cancer versus ascites.
Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
Molecular Chaperones and Thyroid Cancer.
Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages.
Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in glioma.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
Patterns of expression of viral and cytokine gene transcripts during mouse polyoma virus infection.
Peripheral blood mononuclear cell responses to heat shock proteins in patients undergoing stem cell transplantation.
Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65.
Protein expression profiling of endometrial malignancies reveals a new tumor marker: chaperonin 10.
Proteometabolomic analysis of transgenic tomato overexpressing oxalate decarboxylase uncovers novel proteins potentially involved in defense mechanism against Sclerotinia.
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Proteomics profiling of microdissected low- and high-grade prostate tumors identifies lamin A as a discriminatory biomarker.
PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer.
Purification of a non-tagged recombinant BCG heat shock protein 65-Her2 peptide fusion protein from Escherichia coli.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin.
Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice.
Recombinant heat shock protein 65 carrying hepatitis B core antigen induces HBcAg-specific CTL response.
Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages.
Reduced tumorigenicity of B16-F10 mouse melanoma cells transfected with mycobacterial antigen 85A.
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
Simplified Admix Archaeal Glycolipid Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Enhances Protection from Murine Melanoma.
Soluble intercellular adhesion molecule-1 (sICAM-1) and aortic valve calcification in the multi-ethnic study of atherosclerosis (MESA).
Suppression of CCT3 inhibits the proliferation and migration in breast cancer cells.
Synthetic archaeosome vaccines containing triglycosylarchaeols can provide additive and long-lasting immune responses that are enhanced by archaetidylserine.
Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer.
Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
The cytosolic chaperonin CCT/TRiC and cancer cell proliferation.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
The fusion protein of HSP65 with tandem repeats of beta-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma.
The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells.
The proteomics of colorectal cancer: identification of a protein signature associated with prognosis.
Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors.
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.
Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format.
Nephritis
Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice.
Nervous System Diseases
Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease.
Neuroacanthocytosis
[Target antigens in neuroimmunological diseases]
Neuroblastoma
Effects of alcohol on gene expression in neural cells.
H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme disease.
Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.
Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.
Neurodegenerative Diseases
Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates.
Disruption of the chaperonin containing TCP-1 function affects protein networks essential for Rod outer segment morphogenesis and survival.
HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins.
Unfolding the role of chaperones and chaperonins in human disease.
Neuroinflammatory Diseases
Role of Mitochondrial Stress Protein HSP60 in Diabetes-Induced Neuroinflammation.
Nocardia Infections
Genotyping of Nocardia farcinica with multilocus sequence typing.
High Intraspecific Genetic Diversity of Nocardia brasiliensis, a Pathogen Responsible for Cutaneous Nocardiosis Found in France: Phylogenetic Relationships by Using sod and hsp65 Genes.
Isolation, biochemical and molecular identification of Nocardia species among TB suspects in northeastern, Tanzania; a forgotten or neglected threat?
Molecular diagnosis of culture-negative cerebral nocardiosis due to Nocardia abscessus.
Ocular nocardiosis: HSP65 gene sequencing for species identification of Nocardia spp.
Obesity
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis.
Heat Shock Protein 60 in Obesity: Effect of Bariatric Surgery and its Relation to Inflammation and Cardiovascular Risk.
Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity.
Osteoarthritis, Knee
Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
Osteolysis
Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.
Osteoporosis
Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR.
Correction: Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR.
Osteosarcoma
Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60).
Serum antibodies against the heat shock protein 60 are elevated in patients with osteosarcoma.
Ovarian Neoplasms
Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer.
Heat Shock Protein 60 (HSP60) Serves as a Potential Target for the Sensitization of Chemoresistant Ovarian Cancer Cells.
HSP-10 in ovarian cancer: expression and suppression of T-cell signaling.
Pancreatitis
Alteration and role of heat shock proteins in acute pancreatitis.
Alteration of Cpn60 expression in pancreatic tissue of rats with acute pancreatitis.
Ascitic fluid and serum from rats with acute pancreatitis injure rat pancreatic tissues and alter the expression of heat shock protein 60.
Differential induction of HSP60 and HSP72 by different stress situations in rats. Correlation with cerulein-induced pancreatitis.
Expression differences in mitochondrial and secretory chaperonin 60 (Cpn60) in pancreatic acinar cells.
Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats.
Papilloma
Cross-reactivity of Antibodies Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae With Heat Shock Protein 60 and ATP-Binding Protein Correlates to Reduced Mitochondrial Activity in HIBCPP Choroid Plexus Papilloma Cells.
HspE7 treatment of pediatric recurrent respiratory papillomatosis: final results of an open-label trial.
Papilloma, Choroid Plexus
Cross-reactivity of Antibodies Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae With Heat Shock Protein 60 and ATP-Binding Protein Correlates to Reduced Mitochondrial Activity in HIBCPP Choroid Plexus Papilloma Cells.
Papillomavirus Infections
Human Papillomavirus infection requires the CCT Chaperonin Complex.
Technology evaluation: HspE7 (Stressgen).
Paracoccidioidomycosis
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis.
HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis.
Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection.
Paraneoplastic Cerebellar Degeneration
[Target antigens in neuroimmunological diseases]
Paraneoplastic Syndromes, Ocular
[Target antigens in neuroimmunological diseases]
Paratuberculosis
C1q autoantibodies in HIV infection: correlation to elevated levels of autoantibodies against 60-kDa heat-shock proteins.
Polymerase chain reaction-restriction fragment length polymorphism of the rpoB gene for identification of Mycobacterium avium subsp. paratuberculosis and differentiation of Mycobacterium avium subspecies.
Possible association of GroES and antigen 85 proteins with heat resistance of Mycobacterium paratuberculosis.
Rapid differentiation of Mycobacterium avium and M. paratuberculosis by PCR and restriction enzyme analysis.
The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis.
Parkinson Disease
Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson's disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons.
Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease.
Pars Planitis
High levels of IgG class antibodies to recombinant HSP60 kDa of Yersinia enterocolitica in sera of patients with uveitis.
Pelvic Inflammatory Disease
Chlamydia pneumoniae as a respiratory pathogen.
Pemphigoid, Benign Mucous Membrane
Heat shock protein expression in human conjunctiva.
Periodontal Diseases
Evaluation of circulatory and salivary levels of heat shock protein 60 in periodontal health and disease.
Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth.
Periodontal Pocket
Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth.
Periodontitis
Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT.
Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease.
Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients.
Identification of immunoreactive epitopes of the Porphyromonas gingivalis heat shock protein in periodontitis and atherosclerosis.
Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients.
Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins.
Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.
The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease.
Persistent Infection
Association of uterine and salpingeal fibrosis with chlamydial hsp60 and hsp10 antigen-specific antibodies in Chlamydia-infected koalas.
Atherogenic effects of chronic infections: the role of heat shock protein 60 in autoimmunity.
Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression.
Chronic Infections and Atherosclerosis.
Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection.
Phytoplasma Disease
Molecular diagnostic assays based on cpn60 UT sequences reveal the geographic distribution of subgroup 16SrXIII-(A/I)I phytoplasma in Mexico.
Molecular diagnostic tools for detection and differentiation of phytoplasmas based on chaperonin-60 reveal differences in host plant infection patterns.
Plasmacytoma
Myeloma proteins that bind Hsp65 (GroEL) are polyreactive and are found in high incidence in pristine induced plasmacytomas.
Pleuropneumonia
Pyogranulomatous pleuropneumonia caused by Nocardia asiatica in a dog coinfected with canine morbillivirus (canine distemper virus).
Pneumonia
A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation.
Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.
Chlamydial Heat Shock Protein 60 Induces Acute Pulmonary Inflammation in Mice via TLR4/MyD88-Dependent Pathway.
Extent of gamma delta T cell involvement in the pneumonia caused by Sendai virus.
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
MAPK kinase 3 potentiates Chlamydia HSP60-induced inflammatory response through distinct activation of NF-?B.
Modulation of allergic inflammation in the lung by a peptide derived from Mycobacteria tuberculosis chaperonin 60.1.
Mycobacterium tuberculosis Chaperonin 60.1 Inhibits Leukocyte Diapedesis in a Murine Model of Allergic Lung Inflammation.
The safety of post-exposure vaccination of mice infected with Mycobacterium tuberculosis.
The sequence of the groES and groEL genes from the mouse pneumonitis agent of Chlamydia trachomatis.
Pneumonia, Progressive Interstitial, of Sheep
T and B cell responses to mycobacterial 65-kDa heat-shock protein in sheep infected with maedi visna virus.
Polycystic Ovary Syndrome
Effect of HSP10 on apoptosis induced by testosterone in cultured mouse ovarian granulosa cells.
Heat shock protein 10 regulated apoptosis of mouse ovarian granulosa cells.
Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.
Polymyositis
[Target antigens in neuroimmunological diseases]
Pre-Eclampsia
Differential proteomic analysis of highly purified placental cytotrophoblasts in preeclampsia demonstrates a state of increased oxidative stress and reduced cytotrophoblast antioxidant defense.
PP061. The role of heat shock protein 60 and 70 in early- and late-onset preeclampsia differentiation.
Prediabetic State
DiaPep277 (DeveloGen).
Pregnancy, Ectopic
Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60.
Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy.
Seropositivity for the human heat shock protein (Hsp)60 accompanying seropositivity for Chlamydia trachomatis is less prevalent among tubal ectopic pregnancy cases than individuals with normal reproductive history.
Prion Diseases
Chaperonins in disease: mechanisms, models, and treatments.
Prostatic Neoplasms
Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model.
Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 186-193.
Prostatitis
Chlamydia trachomatis Infection Is Related to Poor Semen Quality in Young Prostatitis Patients.
Pruritus
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
Psoriasis
Antibodies to mycobacterial 65-kDa heat shock protein and other immunodominant antigens in patients with psoriasis.
Efficacy and safety of chaperonin 10 in patients with moderate to severe plaque psoriasis: evidence of utility beyond a single indication.
Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis.
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins.
XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator.
Pulmonary Disease, Chronic Obstructive
Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.
HSP60 activity on human bronchial epithelial cells.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Pulmonary Fibrosis
Role of heat shock protein 60 (HSP60) on paraquat intoxication.
Purpura, Thrombocytopenic, Idiopathic
Decreased serum heat shock protein 60 levels in newly diagnosed immune thrombocytopenia patients.
Rabies
Cellular chaperonin CCT? contributes to rabies virus replication during infection.
The chaperonin CCT? is required for efficient transcription and replication of rabies virus.
Reproductive Tract Infections
Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor.
Rickettsia Infections
Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii.
Rosacea
Hypothesis of demodicidosis rosacea flushing etiopathogenesis.
Salmonella Infections
Cloning, expression and characterization of heat shock protein 60 (groEL) of Salmonella enterica serovar Typhi and its role in protective immunity against lethal Salmonella infection in mice.
Salpingitis
Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis.
Sarcoma
Construction of random tumor transcriptome expression library for creating and selecting novel tumor antigens.
Schistosomiasis
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis.
Schistosomiasis japonica
Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica.
Scrub Typhus
Molecular phylogenetic analysis of Orientia tsutsugamushi based on the groES and groEL genes.
Sepsis
Attenuation of mitochondrial unfolded protein response is associated with hepatic dysfunction in septic rats.
miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
Sexually Transmitted Diseases
Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.
Shock, Septic
Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.
Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients, Egyptian multicenter experience.
Sjogren's Syndrome
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
Small Cell Lung Carcinoma
Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
MitCHAP-60 and Hereditary Spastic Paraplegia SPG-13 Arise from an Inactive hsp60 Chaperonin that Fails to Fold the ATP Synthase ?-Subunit.
The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
Squamous Cell Carcinoma of Head and Neck
High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma.
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Starvation
Chaperonin 60 and mitochondrial disease in Dictyostelium.
Expression differences in mitochondrial and secretory chaperonin 60 (Cpn60) in pancreatic acinar cells.
Stiff-Person Syndrome
[Target antigens in neuroimmunological diseases]
Stomach Diseases
Antibodies against Helicobacter pylori heat shock protein 60 aggravate HSP60-mediated proinflammatory responses.
Stomach Neoplasms
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer.
Stroke
The association of C (-260)-->T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients.
Takayasu Arteritis
Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu's arteritis.
Teratocarcinoma
Mycobacterium tuberculosis heat shock protein 10 increases both proliferation and death in mouse P19 teratocarcinoma cells.
Testicular Neoplasms
Gonadal apoptosis during sex reversal of the rice field eel: implications for an evolutionarily conserved role of the molecular chaperone heat shock protein 10.
Tetanus
Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients.
Clonal dominance and selection for similar complementarity determining region 3 motifs among T lymphocytes responding to the HLA-DR3-associated Mycobacterium leprae heat shock protein 65-kd peptide 3-13.
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.
Immunization with a peptide corresponding to chlamydial heat shock protein 60 increases the humoral immune response in C3H mice to a peptide representing variable domain 4 of the major outer membrane protein of Chlamydia trachomatis.
Psychological stress in children may alter the immune response.
Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo.
Strong humoral response elicited by a DNA vaccine targeting gastrin-releasing peptide with optimized adjuvants inhibits murine prostate carcinoma growth in vivo.
Thrombosis
Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis.
The dual role of innate immunity in the antiphospholipid syndrome.
Thyroiditis
Do heat-shock proteins (Hsps)65-reactive lymphocytes in rheumatoid arthritis, Hashimoto's thyroiditis & systemic lupus erythematosus implicate Hsp65 in autoimmunity?
Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.
High expression of heat shock protein 60 in follicular cells of Hashimoto's thyroiditis.
Toxoplasmosis
Mechanisms of HSP65 expression induced by gamma delta T cells in murine Toxoplasma gondii infection.
Trachoma
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60.
Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.
Characterization of B-cell responses to Chlamydia trachomatis antigens in humans with trachoma.
Chlamydia pneumoniae as a respiratory pathogen.
Trophoblastic Neoplasms
A study of early pregnancy factor activity in the sera of women with trophoblastic tumor.
Trypanosomiasis, African
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.
Tuberculosis
A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice.
A major antigen from Mycobacterium tuberculosis which is homologous to the heat shock proteins groES from E. coli and the htpA gene product of Coxiella burneti.
A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice.
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
A Novel Therapeutic and Prophylactic Vaccine (HVJ-Envelope / Hsp65 DNA + IL-12 DNA) against Tuberculosis Using the Cynomolgus Monkey Model.
A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation.
A peptide variant of an arthritis-related T cell epitope induces T cells that recognize this epitope as a synthetic peptide but not in its naturally processed form.
A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis.
Adjuvant arthritis and immunity to the mycobacterial 65 kDa heat shock protein.
Altered Actinobacteria and Firmicutes Phylum Associated Epitopes in Patients With Parkinson's Disease.
An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates.
Antibodies against C-reactive protein cross-react with 60-kilodalton heat shock proteins.
Antibodies to mycobacterial 65-kDa heat shock protein and other immunodominant antigens in patients with psoriasis.
Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis.
Assessment of partial sequencing of the 65-kilodalton heat shock protein gene (hsp65) for routine identification of Mycobacterium species isolated from clinical sources.
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures.
Bacterial luciferase is naturally destabilized in Mycobacterium tuberculosis and can be used to monitor changes in gene expression.
Bovine tuberculosis due to Mycobacterium bovis and other mycobacteria among water buffalo (Bubalus bubalis) from the Brazilian Amazon.
Cell-mediated immune responses and protective efficacy against infection with Mycobacterium tuberculosis induced by Hsp65 and hIL-2 fusion protein in mice.
Chaperonin 10 of Mycobacterium tuberculosis induces a protective immune response to foot-and-mouth disease virus.
Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65.
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage.
Comparative analysis of effects of cytokine gene adjuvants on DNA vaccination against Mycobacterium tuberculosis heat shock protein 65.
Comparative evaluation of polymerase chain reaction and restriction enzyme analysis: two amplified targets, hsp65 and rpoB, for identification of cultured mycobacteria.
Comparative study on the immunogenicity between Hsp70 DNA vaccine and Hsp65 DNA vaccine in human Mycobacterium tuberculosis.
Comparison of PSA-specific CD8+ CTL responses and antitumor immunity generated by plasmid DNA vaccines encoding PSA-HSP chimeric proteins.
Comparison of the Moonlighting Actions of the Two Highly Homologous Chaperonin 60 Proteins of Mycobacterium tuberculosis.
Construction of a eukaryotic expression system of HSP65 gene from Mycobacterium tuberculosis, and anti-HSP65 IgG produced in mice.
Construction, expression and identification of a recombinant BCG vaccine encoding human mycobacterium tuberculosis heat shock protein 65.
Contrasting evolutionary rates in the duplicate chaperonin genes of Mycobacterium tuberculosis and M. leprae.
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
Crystal structure of the 65-kilodalton heat shock protein, chaperonin 60.2, of Mycobacterium tuberculosis.
Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis.
Crystallization, x-ray diffraction and preliminary structure analysis of Mycobacterium tuberculosis chaperonin 10.
Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis.
Detection and characterization of nocardia from patients diagnosed as tuberculosis in egypt.
Detection of Mycobacterium avium & M. tuberculosis from human sputum cultures by PCR-RFLP analysis of hsp65 gene & pncA PCR.
Development and application of multiprobe real-time PCR method targeting the hsp65 gene for differentiation of Mycobacterium species from isolates and sputum specimens.
Development of a Novel PCR Restriction Analysis of the hsp65 Gene as a Rapid Method To Screen for the Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria in High-Burden Countries.
Diagnostic markers for tuberculosis ascites: a preliminary study.
Differential expression of putative drug resistance genes in Mycobacterium tuberculosis clinical isolates.
Differential T-cell recognition of native and recombinant Mycobacterium tuberculosis GroES.
Differentiation of Mycobacterial species by hsp65 duplex PCR followed by duplex-PCR-based restriction analysis and direct sequencing.
Distribution of non-tuberculosis mycobacteria strains from suspected tuberculosis patients by heat shock protein 65 PCR-RFLP.
DNA vaccine using hemagglutinating virus of Japan-liposome encapsulating combination encoding mycobacterial heat shock protein 65 and interleukin-12 confers protection against Mycobacterium tuberculosis by T cell activation.
DNA Vaccine with Discontious T cell Epitopes insertion into HSP65 scaffold as a potential mean to improve immunogenicity of multi-epitope Mycobacterium tuberculosis vaccine.
DNAhsp65 vaccination induces protection in mice against Paracoccidioides brasiliensis infection.
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation.
Effect of r-Mt-Cpn10 on human osteoblast cells.
Efficacy of DNA-hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo.
Endocytosis of Mycobacterium tuberculosis Heat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages.
Evaluation of highly conserved hsp65-specific nested PCR primers for diagnosing Mycobacterium tuberculosis.
Evaluation of hsp65 nested PCR-restriction analysis (PRA) for diagnosing tuberculosis in a high burden country.
Evidence for GroES acting as a transcriptional regulator.
Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization.
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
GroEL2 of Mycobacterium tuberculosis Reveals the Importance of Structural Pliability in Chaperonin Function.
Heat shock proteins and antigens of Mycobacterium tuberculosis.
Helminth coinfection does not affect therapeutic effect of a DNA vaccine in mice harboring tuberculosis.
High genetic diversity revealed by variable-number tandem repeat genotyping and analysis of hsp65 gene polymorphism in a large collection of "Mycobacterium canettii" strains indicates that the M. tuberculosis complex is a recently emerged clone of "M. canettii".
Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases.
Identification of cyclic AMP-regulated genes in Mycobacterium tuberculosis complex bacteria under low-oxygen conditions.
Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice.
Identification of mycobacteria of the MAIS Complex and M. tuberculosis by restriction fragment length polymorphism analysis of hsp65 gene.
Identification of mycobacterial HSP70 reactive human T cell clones discriminating between M. tuberculosis and M. leprae.
Identification of Mycobacterium tuberculosis clinical isolates in Bangladesh by a species distinguishable multiplex PCR.
Identification of promiscuous epitopes from the Mycobacterial 65-kilodalton heat shock protein recognized by human CD4(+) T cells of the Mycobacterium leprae memory repertoire.
Identification of the monocyte activating motif in Mycobacterium tuberculosis chaperonin 60.1.
Immune profiling of leprosy and tuberculosis patients to 15-mer peptides of Mycobacterium leprae and M. tuberculosis GroES in a BCG vaccinated area: implications for development of vaccine and diagnostic reagents.
Immunity to heat shock protein 65--an additional determinant in intimal thickening.
Immunological evaluation of a 12-kilodalton protein of Mycobacterium tuberculosis by enzyme-linked immunosorbent assay.
Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity.
Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice.
Improved diagnosis of mycobacterial infections in formalin-fixed and paraffin-embedded sections with nested polymerase chain reaction.
Inhibition of arteriosclerosis by T-cell depletion in normocholesterolemic rabbits immunized with heat shock protein 65.
Interaction mechanism of Mycobacterium tuberculosis GroEL2 protein with macrophage Lectin-like, oxidized low-density lipoprotein receptor-1: An integrated computational and experimental study.
Interaction of the CD43 Sialomucin with the Mycobacterium tuberculosis Cpn60.2 Chaperonin Leads to Tumor Necrosis Factor Alpha Production.
Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis.
Isolation and characterization of the groES and groEL genes of Bacillus subtilis Marburg.
Isolation, purification and preliminary X-ray characterization of Cpn60-2 (65 kDa heat-shock protein) from Mycobacterium tuberculosis.
Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients.
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Modulation of allergic inflammation in the lung by a peptide derived from Mycobacteria tuberculosis chaperonin 60.1.
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Molecular characterization of mycobacteria isolated from seals.
Monoclonal antibody epitopes of mycobacterial 65-kD heat-shock protein defined by epitope scanning.
Multiple moonlighting functions of mycobacterial molecular chaperones.
Multiplex PCR assay for simultaneous detection and differentiation of Mycobacterium tuberculosis, Mycobacterium avium complexes and other Mycobacterial species directly from clinical specimens.
Mycobacterial Cpn10 promotes recognition of the mammalian homologue by a mycobacterium-specific antiserum.
Mycobacterial DNA in recurrent sarcoidosis in the transplanted lung--a PCR-based study on four cases.
Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients.
Mycobacterium hsp65 DNA entrapped into TDM-loaded PLGA microspheres induces protection in mice against Leishmania (Leishmania) major infection.
Mycobacterium tuberculosis and nontuberculous mycobacterial isolates among patients with recent HIV infection in Mozambique.
Mycobacterium tuberculosis chaperonin 10 and N-truncated fragments. Their synthesis and purification by the isoelectric focusing technique carried out in solution.
Mycobacterium tuberculosis chaperonin 10 forms stable tetrameric and heptameric structures. Implications for its diverse biological activities.
Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops.
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane?
Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease.
Mycobacterium tuberculosis Chaperonin 60.1 Inhibits Leukocyte Diapedesis in a Murine Model of Allergic Lung Inflammation.
Mycobacterium tuberculosis chaperonin 60.1 is a more potent cytokine stimulator than chaperonin 60.2 (Hsp 65) and contains a CD14-binding domain.
Mycobacterium tuberculosis complex DNA does not exist in atheromatous plaques.
Mycobacterium tuberculosis Cpn60.2 (GroEL2) blocks macrophage apoptosis via interaction with mitochondrial mortalin.
Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.
Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
Mycobacterium tuberculosis expresses two chaperonin-60 homologs.
Mycobacterium tuberculosis GroEL homologues unusually exist as lower oligomers and retain the ability to suppress aggregation of substrate proteins.
Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses.
Mycobacterium tuberculosis heat shock protein 10 increases both proliferation and death in mouse P19 teratocarcinoma cells.
Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages.
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.
Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2.
Nontuberculous mycobacteria in patients with suspected tuberculosis and the genetic diversity of Mycobacterium avium in the extreme south of Brazil.
Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions.
Overproduction and purification of Mycobacterium tuberculosis chaperonin 10.
Peripheral blood and pleural fluid mononuclear cell responses to low-molecular-mass secretory polypeptides of Mycobacterium tuberculosis in human models of immunity to tuberculosis.
Potential of High-Affinity, Slow Off-Rate Modified Aptamer (SOMAmer) Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications.
PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response.
Predominant recognition of species-specific determinants of the GroES homologues from Mycobacterium leprae and M. tuberculosis.
Preferential binding with Escherichia coli hsp60 of antibodies prevalent in sera from patients with rheumatoid arthritis.
Preparation, characterization, and in vitro evaluation of isoniazid and rifampicin-loaded archaeosomes.
Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65.
Rapid differentiation of "Mycobacterium canettii" from other Mycobacterium tuberculosis complex organisms by PCR-restriction analysis of the hsp65 gene.
Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.
Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion.
Selective T-cell recognition of the N-terminal peptide of GroES in tuberculosis.
Sequence and structural homologies between M. tuberculosis chaperonin 10 and the MHC class I/II peptide binding cleft.
Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis.
Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 Is a chaperonin.
Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Structure of Mycobacterium tuberculosis chaperonin-10 at 3.5 A resolution.
Study of the gyrB gene polymorphism as a tool to differentiate among Mycobacterium tuberculosis complex subspecies further underlines the older evolutionary age of 'Mycobacterium canettii'.
Suppression of Eis and expression of Wag31 and GroES in Mycobacterium tuberculosis cytosol under anaerobic culture conditions.
T cell immune responses to mycobacterial antigens in Brazilian tuberculosis patients and controls.
T cells against the pathogenic and protective epitopes of heat-shock protein 65 are crossreactive and display functional similarity: novel aspect of regulation of autoimmune arthritis.
T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts.
The 'tubulin-like' S1 protein of Spirochaeta is a member of the hsp65 stress protein family.
The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements.
The Dimeric Structure of the Cpn60.2 Chaperonin of Mycobacterium tuberculosis at 2.8 Å Reveals Possible Modes of Function.
The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis.
The intercellular signaling activity of the Mycobacterium tuberculosis chaperonin 60.1 protein resides in the equatorial domain.
The Mycobacterium tuberculosis BCG-a protein has homology with the Escherichia coli GroES protein.
The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticity.
The treatment of mice infected with multi-drug-resistant Mycobacterium tuberculosis using DNA vaccines or in combination with rifampin.
The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts.
The unusual chaperonins of Mycobacterium tuberculosis.
The Viability and Protein Expression of Beijing/W Lineage Mycobacterium tuberculosis Circulating in Xinjiang, China.
Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses.
Towards understanding the biological function of the unusual chaperonin Cpn60.1 (GroEL1) of Mycobacterium tuberculosis.
Ubiquitin-fusion degradation pathway: a new strategy for inducing CD8 cells specific for mycobacterial HSP65.
[Analysis on human T cell epitopes polymorphisms of five specific antigens of Mycobacterium tuberculosis in 13 areas of China].
[Construction of a secreting prokaryotic shuttle expressing plasmid pBCG-sP-HSP65 and its expression in Mycobacterial smegmatis]
[Construction of the fusion gene of Hsp65 of Mycobacterium tuberculosis and EGFP and preparation of dendritic cell vaccine against tuberculosis]
[CpG motif and tuberculosis immunity]
[Differentiation of micobacteria by multiplex PCR]
[Participation of heat shock proteins in modulation of NF-?B transcription factor activation during bacterial infections].
[Screening and construction of recombinant BCG strains expressing the Ag85B-ESAT6 fusion protein]
[Use of molecular genetic studies to determine the species of the mycobacteria mais and M. tuberculosis complex]
Tuberculosis, Bovine
Improved immunogenicity of DNA vaccination with mycobacterial HSP65 against bovine tuberculosis by protein boosting.
The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis.
Tuberculosis, Pulmonary
Restriction enzyme analysis of the hsp65 gene in clinical isolates from patients suspected of having pulmonary tuberculosis in Teresina, Brazil.
Tuberculosis, Spinal
Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease.
Tularemia
B-cell epitopes in GroEL of Francisella tularensis.
Twins, Conjoined
Cpn20: siamese twins of the chaperonin world.
Urinary Bladder Neoplasms
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.
Uterine Cervical Neoplasms
Combination therapy using human papillomavirus L1/E6/E7 genes and archaeosome: a nanovaccine confer immuneadjuvanting effects to fight cervical cancer.
Expression of heat shock protein 60 kDa is upregulated in cervical cancer.
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Uterine Cervicitis
Human antibody responses to a Chlamydia-secreted protease factor.
Uveitis
Heat shock protein peptides reactive in patients with Behçet's disease are uveitogenic in Lewis rats.
The Role of M. leprae Hsp65 Protein and Peptides in the Pathogenesis of Uveitis.
Uveitis, Anterior
High levels of IgG class antibodies to recombinant HSP60 kDa of Yersinia enterocolitica in sera of patients with uveitis.
Vaccinia
A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice.
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Selective response of gamma delta T-cell hybridomas to orthomyxovirus-infected cells.
Vascular Diseases
Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease.
Vasculitis
Intense immunostaining of heat shock protein 70 within renal interstitium associates with long-term renal survival in an ANCA-associated vasculitis cohort.
Virus Diseases
Chaperonin 10 of Mycobacterium tuberculosis induces a protective immune response to foot-and-mouth disease virus.
Heterogeneity in state and expression of viral DNA in polyoma virus-induced tumors of the mouse.
Visna
T and B cell responses to mycobacterial 65-kDa heat-shock protein in sheep infected with maedi visna virus.
Whooping Cough
Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis.
Bordetella pertussis Proteins Dominating the MHC Class II-Presented Epitope Repertoire in human monocyte derived dendritic cells.
Immunochemical localization of a region of chaperonin-60 important for productive interaction with chaperonin-10.
Localization of the binding site of an antibody affecting ATPase activity of chaperonin cpn60 from Bordetella pertussis.