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Information on EC 5.5.1.4 - inositol-3-phosphate synthase and Organism(s) Zea mays and UniProt Accession Q9FPK7

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IUBMB Comments
Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.
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This record set is specific for:
Zea mays
UNIPROT: Q9FPK7
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The taxonomic range for the selected organisms is: Zea mays
The enzyme appears in selected viruses and cellular organisms
Synonyms
inps, myo-inositol-1-phosphate synthase, mips1, inositol-1-phosphate synthase, mip synthase, pip synthase, myo-inositol 1-phosphate synthase, inositol-3-phosphate synthase, l-myo-inositol-1-phosphate synthase, sll1981, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INS (3) P1 synthase
-
myo-inositol phosphate synthase
-
1L-myo-Inositol-1-phosphate synthase
-
-
-
-
D-Glucose 6-phosphate cycloaldolase
-
-
-
-
D-Glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase
-
-
-
-
D-Glucose 6-phosphate-1L-myoinositol 1-phosphate cycloaldolase
-
-
-
-
D-Glucose 6-phosphate-L-myo-inositol 1-phosphate cyclase
-
-
-
-
D-Glucose-6-phosphate,L-myo-inositol-1-phosphate cycloaldolase
-
-
-
-
Glucocycloaldolase
-
-
-
-
Glucose 6-phosphate cyclase
-
-
-
-
Glucose-6-phosphate inositol monophosphate cycloaldolase
-
-
-
-
Inositol 1-phosphate synthase
-
-
-
-
Inositol 1-phosphate synthetase
-
-
-
-
INPS1
-
-
-
-
IPS
-
-
-
-
L-myo-Inositol 1-phosphate synthetase
-
-
-
-
L-myo-Inositol-1-phosphate synthase
-
-
-
-
MI-1-P synthase
-
-
-
-
MIP synthase
-
-
-
-
myo-inositol phosphate synthase
-
-
myo-Inositol-1-P synthase
-
-
-
-
Myo-inositol-1-phosphate synthase
-
-
-
-
Synthase, myo-inositol 1-phosphate
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cyclization
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
1D-myo-inositol-3-phosphate lyase (isomerizing)
Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-95-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
show the reaction diagram
-
-
-
?
D-Glucose 6-phosphate
L-myo-Inositol 1-phosphate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate
1D-myo-inositol 3-phosphate
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
MIPS is a pivotal biosynthetic enzyme in the myo-inositol pathway, including the synthesis of phytic acid
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
INO1_MAIZE
510
0
56245
Swiss-Prot
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of gene MIPS encoding the enzyme, DNA sequence determination
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
the enzyme is a possible target for genetic modification of maize plants to get low phytic acid containing variants
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shukla, S.; VanToai, T.T.; Pratt, R.C.
Expression and nucleotide sequence of an INS (3) P1 synthase gene associated with low-phytate kernels in maize (Zea mays L.)
J. Agric. Food Chem.
52
4565-4570
2004
Zea mays (Q9FPK7), Zea mays
Manually annotated by BRENDA team
Abid, G.; Silue, S.; Muhovski, Y.; Jacquemin, J.M.; Toussaint, A.; Baudoin, J.P.
Role of myo-inositol phosphate synthase and sucrose synthase genes in plant seed development
Gene
439
1-10
2009
Arabidopsis thaliana, Archaeoglobus fulgidus, Brassica napus, Citrus x paradisi, Euglena gracilis, Glycine max, Hordeum vulgare, Mesembryanthemum crystallinum, Nicotiana tabacum, Oryza sativa, Perilla frutescens, Vigna radiata, Phaseolus vulgaris, Pisum sativum, Sesamum indicum, Solanum tuberosum, Zea mays
Manually annotated by BRENDA team