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Information on EC 5.4.99.66 - alpha-onocerin synthase and Organism(s) Lycopodium clavatum and UniProt Accession A0A125SXN2

for references in articles please use BRENDA:EC5.4.99.66
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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.66 alpha-onocerin synthase
IUBMB Comments
Isolated from the plant Lycopodium clavatum.
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This record set is specific for:
Lycopodium clavatum
UNIPROT: A0A125SXN2
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The taxonomic range for the selected organisms is: Lycopodium clavatum
The expected taxonomic range for this enzyme is: Lycopodium clavatum
Synonyms
LCD, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LCD
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-
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SYSTEMATIC NAME
IUBMB Comments
pre-alpha-onocerin mutase (cyclizing, alpha-onocerin-forming)
Isolated from the plant Lycopodium clavatum.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pre-alpha-onocerin
alpha-onocerin
show the reaction diagram
i.e. polypoda-8(26),13,17-trien-21,22-epoxy-3beta-ol
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
both dioxidosqualene cyclase LCC and dioxidosqualene cyclase LCD are required to produce alpha-onocerin
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LCD_LYCCL
766
0
87194
Swiss-Prot
other Location (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Araki, T.; Saga, Y.; Marugami, M.; Otaka, J.; Araya, H.; Saito, K.; Yamazaki, M.; Suzuki, H.; Kushiro, T.
Onocerin biosynthesis requires two highly dedicated triterpene cyclases in a fern Lycopodium clavatum
ChemBioChem
17
288-290
2016
Lycopodium clavatum (A0A125SXN2)
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Manually annotated by BRENDA team