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Information on EC 5.3.3.9 - prostaglandin-A1 DELTA-isomerase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
5.3.3.9
-
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RECOMMENDED NAME
GeneOntology No.
prostaglandin-A1 DELTA-isomerase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
intramolecular oxidoreduction
-
-
-
-
isomerization
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate DELTA10-DELTA11-isomerase
Interconverts prostaglandin A1 and prostaglandin C1.
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CAS REGISTRY NUMBER
COMMENTARY
9055-01-0
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Bos taurus
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
i.e. prostaglandin B1
-
(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid
(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
i.e. prostaglandin A1
-
-
-
(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
?
-
i.e. prostaglandin A2
-
-
-
(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
?
-
i.e. prostaglandin A2
-
-
-
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8 - 9
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 10
-
pH 6.0: about 30% of maximal activity, pH 10.0: about 35% of maximal activity
6.5 - 10
-
pH 6.5: about 35% of maximal activity, pH 9.5-10.0: maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
60
70
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
10% loss of activity after dialysis
loss of activity after pepsin digestion
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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LINKS TO OTHER DATABASES (specific for EC-Number 5.3.3.9)
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