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Information on EC 5.1.3.36 - heparosan-glucuronate 5-epimerase for references in articles please use BRENDA:EC5.1.3.36
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EC Tree
IUBMB Comments The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.
The expected taxonomic range for this enzyme is: Achatina fulica
Synonyms
hg-5epi,
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[heparosan]-D-glucuronate = [acharan]-L-iduronate
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[heparosan]-D-glucuronate 5-epimerase
The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.
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[heparosan]-D-glucuronate
[heparosan]-L-iduronate
[heparosan]-D-glucuronate
[heparosan]-L-iduronate
A0A0C6EX43
it is suggested that the enzyme participates in the biosynthetic pathway of acharan sulfate
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[heparosan]-D-glucuronate
[heparosan]-L-iduronate
A0A0C6EX43
no activity with [heparosan]-N-sulfate D-glucuronate. At equilibrium of the epimerization, the proportion of IdoA in the reaction product reaches up to 30% of total hexuronic acid
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[heparosan]-D-glucuronate
[heparosan]-L-iduronate
A0A0C6EX43
it is suggested that the enzyme participates in the biosynthetic pathway of acharan sulfate
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CHAPS
A0A0C6EX43
0.1%, completely abolishes activity
sodium deoxycholate
A0A0C6EX43
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5.5 - 7
A0A0C6EX43
pH 5.0: about 50% of maximal activity, pH 7.0: about 40% of maximal activity
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A0A0C6EX43
UniProt
brenda
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75000
A0A0C6EX43
x * 75000, SDS-PAGE
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A0A0C6EX43
x * 75000, SDS-PAGE
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35
A0A0C6EX43
unstable above
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expressed in insect cells
A0A0C6EX43
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Mochizuki, H.; Yamagishi, K.; Suzuki, K.; Kim, Y.S.; Kimata, K.
Heparosan-glucuronate 5-epimerase: molecular cloning and characterization of a novel enzyme
Glycobiology
25
735-744
2015
Achatina fulica (A0A0C6EX43), Achatina fulica
brenda
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