Disease on EC 4.4.1.20 - leukotriene-C4 synthase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anaphylaxis
Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase.
The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase.
Aortic Aneurysm, Abdominal
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.
Asthma
5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States.
5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma.
Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma.
Analysis of 927T> C CYSLTRI and -444A > C LTC4S polymorphisms in patients with asthma.
Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
Association between leukotriene C4 synthase A-444C polymorphism and asthma in Chinese Han population in Beijing.
Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans.
Association of Leukotriene C4 Synthase A-444C Polymorphism with Asthma and Asthma Phenotypes in Romanian Population.
Association of the -1072G/A Polymorphism in the LTC4S Gene with Asthma in an Indian Population.
Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan.
Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma.
Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist.
Cysteinyl Leukotriene Receptor 1 and Health Effects of Particulate Exposure in Asthma.
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies.
Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis.
Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity.
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphism.
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma.
Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis.
Genetic mechanism of aspirin-induced urticaria/angioedema.
Implications of pharmacogenomics in the current and future treatment of asthma.
Lack of an association between a newly identified promoter polymorphism (-1702G > A) of the leukotriene C4 synthase gene and aspirin-intolerant asthma in a Korean population.
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma.
Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma.
Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma.
Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.
Leukotriene generation and clinical implications.
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase.
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.
LTC4 synthase. Enzymology, biochemistry, and molecular characterization.
Molecular cloning and expression of human leukotriene-C4 synthase.
Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene.
The -444A/C Polymorphism in the LTC4S Gene and Risk of Asthma: Meta-analysis.
Uncertain biologic relevance of polymorphisms of leukotriene C4 synthase in asthma.
[Relationship between the efficacy of inhaled corticosteroids and the leukotriene expression in children with asthma]
Asthma, Aspirin-Induced
Aspirin-induced rhinitis and asthma.
Leukotriene C4 synthase polymorphism and aspirin-induced asthma.
Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.
Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma.
Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.
Pathogenesis of nonsteroidal antiinflammatory drug-induced asthma.
Asthma, Exercise-Induced
Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA).
The leukotriene C4 synthase (A-444C) promoter polymorphism is associated with the severity of exercise-induced asthma in Korean children.
Atherosclerosis
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Blast Crisis
Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate.
Bronchial Hyperreactivity
LTC4 synthase. Enzymology, biochemistry, and molecular characterization.
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.
Bronchitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Cardiovascular Diseases
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals.
Cerebrovascular Disorders
Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease.
Dermatitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Eosinophilia
Molecular and cellular staging for the severity of chronic rhinosinusitis.
Gastroesophageal Reflux
Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis.
Glomerulonephritis
Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
Hepatitis
[Gene expressions of LTC4 synthase homologs in Con A-induced mouse hepatitis and regulative effect of cyclosporine A]
Hyperlipidemias
Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.
Hypersensitivity
Specific induction of LTC4 synthase by retinoic acid in rat basophilic leukemia-1 cells.
Ischemic Attack, Transient
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Leukemia
Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells.
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.
Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone.
Inhibition of leukotriene synthesis by azelastine.
Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells.
Leukotriene C4 synthase from rat basophilic leukemia cell microsomes.
Photoaffinity labelling of human leukotriene C4 synthase in THP-1 cell membranes.
Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells.
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
Leukemia, Erythroblastic, Acute
Induction of leukotriene C4 synthase activity in differentiating human erythroleukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inverse relationship between myeloid maturation and leukotriene C4 synthase expression in normal and leukemic myelopoiesis-consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemia.
Leukemia, Myeloid
[Identification of acute leukemia-specific genes from leukemia recipient/sibling donor pairs by distinguishing study with oligonucleotide microarrays]
Lung Diseases, Obstructive
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Mastocytoma
Leukotriene C4 synthase: characterization in mouse mastocytoma cells.
Melanoma
Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4.
Myocardial Ischemia
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Nasal Polyps
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Neoplasms
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Effect of lipopolysaccharide and cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.
Lipopolysaccharide and cytokines modulate leukotriene (LT)B4 and LTC4 production by porcine endometrial endothelial cells.
Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells.
Nephritis
Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.
Pneumonia
Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation.
Pulmonary Disease, Chronic Obstructive
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Pulmonary Eosinophilia
Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.
Reperfusion Injury
V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-?B activation pathway.
Rhinitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Rhinitis, Allergic
Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis.
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Sinusitis
Advances in upper airway diseases and allergen immunotherapy.
Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis.
Stroke
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China.
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Tachycardia
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis.
Urticaria
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant.
The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria.