Information on EC 4.3.1.26 - chromopyrrolate synthase

This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin . Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center . The enzyme also possesses catalase activity.